Effect of Skimmed Milk on the Absorption and Metabolism of5-Fluorouracil (5-FU) in Animals

Abstract

Several modalities of drug administration have been investigated to improve bioavailability and to reduce 5-FU related toxicity. The aim of present study was to evaluate the effect of skimmed milk on the absorption and metabolism of 5-FU in rabbits, mice and dogs. It was further aimed to determine its route related toxicity in rabbits.