Anti-nociceptive and Anti-Inflammatory Effects of Prosopis Cineraria Seed Extract in Animal Models
| Author | Neda NaeimiRad | en |
| Author | Zahra Mousavi | en |
| Author | Jinous Asgarpanah | en |
| Orcid | Neda NaeimiRad [0009-0006-0865-3737] | en |
| Orcid | Zahra Mousavi [0000-0001-6524-491X] | en |
| Orcid | Jinous Asgarpanah [0000-0003-1947-4073] | en |
| Issued Date | 2026-11-30 | en |
| Abstract | Background: Complementary medicine, particularly the use of medicinal plants, has gained increasing attention as a potential source of affordable therapeutic agents with fewer adverse effects. Objectives: This study investigated the analgesic and anti-inflammatory effects of Prosopis cineraria seed extract (Prosopis cineraria seed extract (PCSE)) in experimental animal models. Methods: Analgesic activity was evaluated using the hot plate and acetic acid-induced writhing tests in male mice (n = 30 per assay). Animals received Prosopis cineraria seed extract (PCSE) at 100, 200, or 300 mg/kg, while morphine and saline served as positive and negative controls, respectively. Anti-inflammatory activity was assessed using carrageenan-induced paw edema and cotton pellet-induced granuloma models in male Wistar rats (n = 30 per assay). PCSE was administered at the same doses, with mefenamic acid and indomethacin used as reference drugs in the respective models. Data were analyzed using GraphPad Prism version 8.0.2, with P < 0.05 considered statistically significant. Results: PCSE produced a significant but transient analgesic effect in the hot plate test at 30 min at all tested doses (P < 0.05); this effect was not maintained at 1 or 2 h. In the acetic acid-induced writhing test, PCSE at 100, 200, and 300 mg/kg significantly reduced writhing responses by 46.23%, 64.93%, and 76.35%, respectively, compared with the control group, whereas morphine produced a 75.33% reduction. In the carrageenan-induced paw edema model, PCSE reduced edema by 40.74%, 46.61%, and 49.07% at 100, 200, and 300 mg/kg, respectively, at 2 h, compared with a 51.54% reduction with mefenamic acid. PCSE showed no significant activity in the cotton pellet-induced granuloma model. Conclusions: PCSE exhibited significant anti-nociceptive activity against chemically induced visceral pain and anti-inflammatory activity against acute inflammation, but its effect on thermal nociception was transient, and it was ineffective against chronic inflammation. These findings provide preliminary evidence of biological activity in the specific animal models investigated and warrant further chemical, pharmacological, mechanistic, and toxicological investigation. | en |
| DOI | https://doi.org/10.5812/jjnpp-167399 | en |
| URI | https://brieflands.com/journals/jjnpp/articles/167399 | en |
| Keyword | Prosopis Cineraria | en |
| Keyword | Analgesic | en |
| Keyword | Anti-inflammatory | en |
| Keyword | Rats | en |
| Keyword | Mice | en |
| Publisher | Brieflands | en |
| Title | Anti-nociceptive and Anti-Inflammatory Effects of <i>Prosopis Cineraria</i> Seed Extract in Animal Models | en |
| Type | Research Article | en |
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