Acylated Ghrelin, Growth Hormone and IGF-1 Levels in the Cord Blood of Small for Gestational Age Newborns
| Author | Nastaran Khosravi | en |
| Author | Farhad Abolhasan Choobdar | en |
| Author | Nasrin Khalesi | en |
| Author | Arash Bordbar | en |
| Author | Bagher Larijani | en |
| Author | Zahra Arab | en |
| Author | Mitra Nourbakhsh | en |
| Orcid | Mitra Nourbakhsh [0000-0002-6716-0354] | en |
| Issued Date | 2016-11-30 | en |
| Abstract | Background: Ghrelin is a pleiotropic hormone that regulates feeding and energy balance and stimulates growth hormone release. Ghrelin also exerts developmental and organizational effects during prenatal life. Objectives: The aim of this study was to determine ghrelin levels in cord blood of small for gestational age (SGA) infants and its association with GH (growth hormone) and IGF-1 levels (insulin-like growth factor-1). Methods: Cord blood sample was obtained from 31 SGA and 25 appropriate for gestational age (AGA) infants. Acylated ghrelin, GH, and IGF-1 levels were measured by enzyme-linked immunosorbent assay. Results: No significant differences were observed in ghrelin and GH concentrations between SGA and AGA infants. However, IGF-1 levels were significantly lower in SGA infants. Cord blood ghrelin was negatively correlated with the infants’ birth weight (r = -0.33, P = 0.013); on the other hand, IGF-1 level was positively correlated with birth weight (r = 0.43, P = 0.002). Conclusions: IGF-1 has the most significant effect on intrauterine growth. Acylated ghrelin is detectable in cord blood and correlated with birth weight, suggesting a role in intrauterine development, but its level is not affected by intrauterine growth retardation. | en |
| DOI | https://doi.org/10.17795/compreped-42809 | en |
| Keyword | Ghrelin | en |
| Keyword | Growth Hormone (GH) | en |
| Keyword | IGF-1 | en |
| Keyword | Small for Gestational Age (SGA) | en |
| Keyword | Appropriate for Gestational Age (AGA) | en |
| Keyword | Intrauterine Growth | en |
| Publisher | Brieflands | en |
| Title | Acylated Ghrelin, Growth Hormone and IGF-1 Levels in the Cord Blood of Small for Gestational Age Newborns | en |
| Type | Research Article | en |
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