Role of Epsilon Aminocaproic acid & Tranexamic Acid, vs Placebo in Reduction of mediastinal Bleeding following Open Heart Surgery

Abstract

Post-operative bleeding is one of the Challenging issues in cardiacsurgery. The Excessive bleeding and need for transfusion of blood products may increases the patients’ mortality and morbidity. Although use of antifibrinolytics has long been the issue of interest but recently according to some reports of sudden death after use of aprotinin has encountered great limitations. So we decided to find an alternative drug for aprotinin