Fast Electrocatalytic Determination of Methimazole at an Activated Glassy Carbon Electrode
| Author | Fahimeh Jalali | en |
| Author | Zahra Hatami | en |
| Issued Date | 2016-10-31 | en |
| Abstract | A fast and simple voltammetric method for the determination of methimazole in pharmaceutical products was reported. A glassy carbon electrode was pretreated by anodization at +1.75 V (vs. SCE) for 5 min, followed by potential cycling in the range of 0.3-1.3 V (20 cycles). The pretreated electrode showed an excellent electrocatalytic effect on the oxidation of methimazole. Compared with untreated electrode, a large decrease (~300 mV) in the oxidation peak of methimazole was observed. The oxidation peak current at the new potential (0.4 V vs. SCE) was linearly dependent on the concentration of methimazole in the range of 7.0 - 130 μM with a detection limit of 3.7 μM (S/N = 3). The method was successfully used in the determination of methimazole in thyramozol tablets. Due to the simple and fast electrode preparation, there is no need for electrode cleaning or storage. | en |
| DOI | https://doi.org/10.22037/ijpr.2016.1837 | en |
| Keyword | Methimazole | en |
| Keyword | Pretreated glassy carbon electrode | en |
| Keyword | Square wave voltammetry | en |
| Keyword | Tablets | en |
| Publisher | Brieflands | en |
| Title | Fast Electrocatalytic Determination of Methimazole at an Activated Glassy Carbon Electrode | en |
| Type | Original Article | en |
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