Effects of Silymarin Supplementation on Leptin, Adiponectin and Paraoxanase Levels and Body Composition During Exercise: A Randomized Double-Blind Placebo Controlled Clinical Trial
| Author | Saeed Shirali | en |
| Author | Nafiseh Shokri Mashhadi | en |
| Author | Damoon Ashtary-Larky | en |
| Author | Tahereh Safania | en |
| Author | Alireza Barari | en |
| Orcid | Alireza Barari [0000-0001-5199-463X] | en |
| Issued Date | 2016-11-30 | en |
| Abstract | Background: Silymarin has powerful antioxidant properties, but its effects on athletic performance are poorly understood. Objectives: The present study was undertaken to evaluate the effects of 4 weeks of endurance or strength exercise, with or without silymarin, on body composition, paraoxonase (PON), leptin and adiponectin levels in untrained men. Methods: A total of 45 untrained men were divided into 5 groups (n = 9): endurance training with placebo (ET + P), endurance training with 140 mg of silymarin/day (ET + S), strength training with placebo (ST + P), strength training with 140 mg of silymarin/day (ST + S) and placebo (C). Anthropometrical and VO2max measurements and ELISA assay for PON, leptin and adiponectin levels were performed at the beginning and after the 4-week of the study Results: There was a significant decrease in weight and body mass index in the ET + P and ET + S groups and increases in ST + P and ST + S (P < 0.05) groups. Body fat declined in all four trained groups (P < 0.001). Peak oxygen uptake (VO2max) improved in both ET + P and ET + S subjects. Paraoxonase (PON) was increased only in ET + S group (P < 0.05). Adiponectin was increased in all four groups (P < 0.05). Circulating leptin remained unchanged within all interventions. Conclusions: The present study has demonstrated that a combination of exercise and silymarin can improve body composition and adiponectin levels. | en |
| DOI | https://doi.org/10.17795/jjnpp-30044 | en |
| Keyword | Exercise | en |
| Keyword | Silymarin | en |
| Keyword | Body Composition | en |
| Keyword | Paraoxonase | en |
| Keyword | Adiponectin | en |
| Keyword | Leptin | en |
| Publisher | Brieflands | en |
| Title | Effects of Silymarin Supplementation on Leptin, Adiponectin and Paraoxanase Levels and Body Composition During Exercise: A Randomized Double-Blind Placebo Controlled Clinical Trial | en |
| Type | Research Article | en |
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