Synthesis and Vasorelaxant Effect of 9-aryl-1,8-acridinediones asPotassium Channel Openers in Isolated Rat Aorta
| Author | Mohsen Imenshahidi | en |
| Author | Farzin Hadizadeh | en |
| Author | Asieh Firoozeh-Moghadam | en |
| Author | Mahmoud Seifi | en |
| Author | Atefeh Shirinbak | en |
| Author | Mohammad Bagher Gharedaghi | en |
| Issued Date | 2012-01-31 | en |
| Abstract | ATP-sensitive potassium (KATP) channel openers have a relaxation effect due to the lower cellular membrane potential and inhibit calcium influx. There has been considerable interest in exploring KATP channel openers in the treatment of various diseases such as cardiovascular, cerebrovascular, and urinary system disease and premature labor. The purpose of this study was to synthesize 3,3,6,6-tetramethy l-9-aryl-octahydro-1,8-acridindiones and investigate their effects on vascular potassium channels and mechanism of induced relaxations on phenylephrine-induced contractile responses in isolated rings of rat aortic smooth muscle. | en |
| DOI | https://doi.org/10.22037/ijpr.2011.1029 | en |
| Keyword | Potassium channels | en |
| Keyword | Isolated | en |
| Keyword | Vasorelaxant | en |
| Keyword | ATP-sensitive potassium | en |
| Publisher | Brieflands | en |
| Title | Synthesis and Vasorelaxant Effect of 9-aryl-1,8-acridinediones asPotassium Channel Openers in Isolated Rat Aorta | en |
| Type | Original Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- ijpr-11-229.pdf
- Size:
- 427.52 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF