SUSTAINED RELEASE FORMULATION AND IN-VITRO EVALUATION OF IBUPROFEN-HPMC MATRIX TABLETS

Abstract

Ibuprofen is one of the safest and most potent non-steroidal anti-inflammatory drug (NSAID) available in the market. To improve the bioavailability of ibuprofen, a thorough preformulation trial was undertaken. As a part of these studies, different formulations of ibuprofen containing different amounts of hydroxypropylmethylcellulose (HPMC) and microcrystalline cellulose (Avicel®) were made and evaluated. The superior formulation which released the drug at constant rate of about 60 mg/hour was chosen. Then the effect of changing particle size of granulation was studied. Two different crystal forms of ibuprofen were prepared and their release pattern were studied. Produced crystal forms of ibuprofen showed different release mechanisms in comparison with the original form. Incorporation of various proportions of tween 80 and Sodium Lauryl Sulfate (SLS) as wetting agent on the release rate of ibuprofen in the formulations were also studied. Sodium lauryl sulphate disintegrated the tablets faster than tween 80.