Herbal Nanoemulsion in Topical Drug Delivery and Skin Disorders: Green Approach

Abstract

A topical drug delivery system can be a future trend for drug delivery because of the availability of the largest surface area of skin than any other organ. Although the skin has some advantages such as ease of application, patient compliance, and safety, it has many disadvantages such as permeability and bioavailability via first-pass metabolism and others. Nanoemulsion can be a future trend for topical delivery of drugs because of its very fine droplet size range, lipophilic and/or hydrophilic nature, and suitability for various administration routes such as parenteral, oral, topical, intranasal, ocular, and pulmonary. The contents of nanoemulsions make them suitable for human use because the oil/lipid, water, surfactants, and co-surfactants used in the formulation of nanoemulsion are relatively safe and nontoxic. Nowadays, people are more attracted to natural preparations as of their inherited qualities and fewer side effects. Due to herbal drugs’ compatibility in nanoemulsion, it is considered the best technology for the green approach of the medicine system. The article presented the foundation for the above statement by different literature surveys on the herbal nanoemulsion formulations.