Cardiac Autonomic Modulation Following a 50 mg Oral Dose of Dimenhydrinate in Healthy Young Adults: A Double-Blind Randomized Controlled Trial
| Author | Sahabeh Rouhi Ardeshiri | en |
| Author | Mohammad Taghi Hedayati Godarzi | en |
| Author | Hoda Shirafkan | en |
| Author | Motahareh Rouhi Ardeshiri | en |
| Author | Esmaeil Akbari | en |
| Author | Roghayeh Pourkia | en |
| Orcid | Hoda Shirafkan [0000-0002-5682-1153] | en |
| Issued Date | 2026-06-30 | en |
| Abstract | Background: Heart rate variability (HRV) reflects beat-to-beat changes in the cardiac cycle that result from interactions between sinus node cells and the autonomic nervous system. Dimenhydrinate is a first-generation H1 receptor antihistamine of the monoethanolamine class. Objectives: This study aimed to evaluate the effects of oral dimenhydrinate on cardiac autonomic activity using heart rate variability (HRV) indices. Methods: This double-blind crossover study included volunteers who attended two sessions separated by a 2-week interval. In each session, a 5-minute electrocardiogram (ECG; lead II) was recorded at baseline and at multiple time points within 4 hours after oral administration of either placebo or 50 mg dimenhydrinate. Time- and frequency-domain HRV parameters were calculated and statistically analyzed. Results: Placebo had no significant effects on any HRV indices. Administration of 50 mg dimenhydrinate resulted in a significant increase in mean SDNN (standard deviation of normal-to-normal intervals) at 90 minutes. At 4 hours after administration, both RMSSD (root mean square of successive differences) and PNN50% (percentage of successive NN intervals differing by more than 50 ms) were significantly elevated in the dimenhydrinate group, indicating enhanced parasympathetic modulation. Conclusions: These findings suggest that oral dimenhydrinate, which crosses the blood-brain barrier, modulates cardiac autonomic balance by enhancing parasympathetic activity and reducing sympathetic dominance via H1 receptor antagonism. | en |
| DOI | https://doi.org/10.69107/intjcardiovascpract-170673 | en |
| URI | https://brieflands.com/journals/ijcp/articles/170673 | en |
| Keyword | Dimenhydrinate | en |
| Keyword | Heart Rate Variability | en |
| Keyword | Autonomic Nervous System | en |
| Publisher | Brieflands | en |
| Title | Cardiac Autonomic Modulation Following a 50 mg Oral Dose of Dimenhydrinate in Healthy Young Adults: A Double-Blind Randomized Controlled Trial | en |
| Type | Research Article | en |
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