UPLC–ESI-PDA–Ms<sup>n</sup> Profiling Of Phenolics Involved In Biological Activities Of The Medicinal Plant <i>Halocnemum Strobilaceum </i>(Pall<i>.</i>)
| Author | Heba Handoussa | en |
| Author | Walid AbdAllah | en |
| Author | Mona AbdelMohsen | en |
| Issued Date | 2019-01-31 | en |
| Abstract | Halocnemum strobilaceum is a halophyte present in the humid and arid bioclimatic regions of Egypt. The current study aimed at UPLC/PDA/ESI-MSn qualitative chemical profiling of the phyto-constituents underlining both antioxidant and cytotoxic activities of the bio-active fraction in comparison with the other fractions. It resulted in detection of several related compounds to prenylated flavonol icariin as a first report in this species. Results showed that ethyl acetate exhibits an appreciable antioxidant activity using in-vitro DPPH assay with percentage of 82.35% and remarkable anticancer capacity against most common types of cancer in Egypt; breast (MCF-7), human prostate (PC-3) cancer cell lines, and human lung carcinoma (A-549) with IC50 43.1± 2 µg/mL, 115±5 µg/ml, and 53.3±3 µg/mL respectively. These findings point out the appropriate solvent for extraction of the bio-phenolics with this halophyte which is a considerable source of remarkable potential secondary metabolites that exhibit original and interesting anticancer capacity. | en |
| DOI | https://doi.org/10.22037/ijpr.2019.2356 | en |
| Keyword | Halocnemum strobilaceum | en |
| Keyword | Phenolics | en |
| Keyword | UPLC/PDA/ESI/MSn | en |
| Keyword | Anticancer | en |
| Keyword | Antioxidant | en |
| Publisher | Brieflands | en |
| Title | UPLC–ESI-PDA–Ms<sup>n</sup> Profiling Of Phenolics Involved In Biological Activities Of The Medicinal Plant <i>Halocnemum Strobilaceum </i>(Pall<i>.</i>) | en |
| Type | Original Article | en |
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