Chronic Diarrhea as a Presenting Manifestation of Common Variable Immunodeficiency

Abstract

Common variable immunodeficiency (CVID) is one of the primary immunodeficiencies, which usually presents with recurrent bacterial infections, particularly in respiratory and gastrointestinal systems and hypogammaglobulinemia. We present here a case of CVID who was suffering from chronic watery diarrhea since 3 months before admission. Past medical history was uneventful about recurrent infections. No abnormality was revealed on physical examination. After thorough investigations about other possible causes of chronic diarrhea, and based on laboratory data of hypogammaglobuliemia, we considered him as a case of CVID with an isolated manifestation.