Protective Effect of Crocin on Gastric Mucosal Lesions Induced by Ischemia-Reperfusion Injury in Rats
| Author | Seyyed Ali Mard | en |
| Author | Seyyed Mojib Azad | en |
| Author | Akram Ahangarpoor | en |
| Issued Date | 2016-03-31 | en |
| Abstract | The present study aimed to evaluate the protective effect of crocin on gastric mucosal lesions caused by ischemia-reperfusion (I/R) injury in rats. Forty male rats were randomly divided into sham, control (I/R injury) and three crocin-pretreated groups. To induce I/R lesions, the celiac artery was clamped for 30 min and then the clamp was removed to allow reperfusion for 3 h. Pretreated-rats received crocin (7.5, 15 or 30 mg/kg, i.p.) 30 min prior to the induction of I/R injury. Samples of gastric mucosa were collected to measure the following variables: 1 mRNA expression of superoxide dismutase (SOD) and glutathione peroxidase (Gpx) by RT-PCR; 2 activity of superoxide dismutase and glutathione peroxidase and 3 tissue levels of malonyldehaldehyde (MDA). | en |
| DOI | https://doi.org/10.22037/ijpr.2016.1810 | en |
| Keyword | Crocin | en |
| Keyword | Superoxide dismutase | en |
| Keyword | Glutathione peroxidase | en |
| Keyword | Ischemia-reperfusion injury | en |
| Keyword | Rat | en |
| Publisher | Brieflands | en |
| Title | Protective Effect of Crocin on Gastric Mucosal Lesions Induced by Ischemia-Reperfusion Injury in Rats | en |
| Type | Original Article | en |