Chemical Composition and Biological Activities of Endophytic Fungus <i>Talaromyces Wortmannii</i> LGT-4, Cultured in CYM Medium
| Author | Zhong-Duo Yang | en |
| Author | Yu Zhang | en |
| Author | Wei-Hua Zhao | en |
| Author | Zong-Mei Shu | en |
| Issued Date | 2020-04-30 | en |
| Abstract | In the present study, nine compounds (1-9) were isolated from Talaromyces wortmannii LGT-4 (an endophytic fungus from Tripterygium wilfordi) which was cultured in CYM Medium. Their structures were determined as 4-hydroxyphthalide (1), Fumitremorgin C (2), Ergosterol (3), 3-(2-hydroxypropyl)-8-hydroxy-3,4- dihydroisocoumarin (4), Cis-cyclo(L-Ala-L-Pro) (5), 6-Amino-3-(4-hydroxybenzyl)- 1,4-diazonane-2,5-dione (6), Aspergillumarin B (7), Deacetylisowortmin B (8), and Entonaemin A (9) based on NMR spectral data, as well as comparing with previous literature data. This is the first report of the isolation of compounds 1-2 and 4-7 from Talaromyces genus. All compounds were tested for their monoamine oxidase and phosphoinositide 3-kinase (PI3Kα) inhibitory activities. Compound 1, 5 showed moderate anti-monoamine oxidase activity with IC50 value of 35 μg/mL, 28 μg/mL, respectively. Compound 9 showed PI3Kα inhibitory activity with IC50 value of 10.3 μg/mL. | en |
| DOI | https://doi.org/10.22037/ijpr.2020.1101051 | en |
| Keyword | Endophytic fungus | en |
| Keyword | Monoamine oxidase inhibitors | en |
| Keyword | Chemical composition | en |
| Keyword | Talaromyces wortmannii | en |
| Keyword | Tripterygium wilfordi | en |
| Publisher | Brieflands | en |
| Title | Chemical Composition and Biological Activities of Endophytic Fungus <i>Talaromyces Wortmannii</i> LGT-4, Cultured in CYM Medium | en |
| Type | Original Article | en |
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