Predictive Value of D-dimer in Children with Acute Pyelonephritis
| Author | Sahar Sadr Moharerpour | en |
| Author | Leily Mohajerzadeh | en |
| Author | Azar Nickavar | en |
| Author | Alireza Haghbin Toutounchi | en |
| Orcid | Sahar Sadr Moharerpour [0000-0002-9083-1822] | en |
| Orcid | Leily Mohajerzadeh [0000-0002-9945-8964] | en |
| Orcid | Azar Nickavar [0000-0003-0740-0667] | en |
| Orcid | Alireza Haghbin Toutounchi [0000-0002-5446-6346] | en |
| Issued Date | 2025-01-31 | en |
| Abstract | Background: The diagnosis of acute febrile urinary tract infection (UTI) relies on various clinical and laboratory findings, which have shown conflicting results. Objectives: This study aimed to evaluate the utility of serum D-dimer in distinguishing acute pyelonephritis (APN) from other acute bacterial febrile infections. Methods: This cross-sectional study included 47 children with a confirmed UTI (verified by positive urine culture) and 47 children with other bacterial febrile infections. Serum D-dimer levels were measured in all patients before starting antibacterial treatment. Results: A total of 94 febrile children were evaluated, with females outnumbering males. Significant differences between the two groups were observed for microscopic hematuria (P = 0.044), bacteriuria (P < 0.001), white blood cell (WBC) count (P = 0.047), and hemoglobin (Hgb) (P = 0.035), but not for serum D-dimer (P = 0.327). Binary logistic regression analysis revealed that Hgb (P = 0.019) had a significant predictive value in APN, whereas serum D-dimer did not. Serum D-dimer was found to be an inaccurate biomarker for distinguishing febrile UTI from other bacterial febrile infections. Conclusions: Based on our findings, while D-dimer level increase in various acute bacterial febrile infections, they are not appropriate in differentiating febrile UTI from other bacterial infections. | en |
| DOI | https://doi.org/10.5812/apid-145153 | en |
| Keyword | Acute Pyelonephritis | en |
| Keyword | Urinary Tract Infection | en |
| Keyword | D-dimer | en |
| Keyword | Children | en |
| Publisher | Brieflands | en |
| Title | Predictive Value of D-dimer in Children with Acute Pyelonephritis | en |
| Type | Research Article | en |
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