Salivary Lactate Dehydrogenase, C-Reactive Protein, and Cancer Antigen 125 Levels in Patients with Oral Lichen Planus and Oral Squamous Cell Carcinoma
| Author | Marieh Honarmand | en |
| Author | Ramin Saravani | en |
| Author | Leila Farhad-Mollashahi | en |
| Author | Amin Smailpoor | en |
| Orcid | Marieh Honarmand [0000-0001-7310-559X] | en |
| Orcid | Ramin Saravani [0000-0003-1941-3617] | en |
| Orcid | Leila Farhad-Mollashahi [0000-0003-3922-440X] | en |
| Issued Date | 2021-03-31 | en |
| Abstract | Background: Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity and oral lichen planus (OLP) is considered a premalignant disease. Objectives: This study aims at comparing the salivary levels of lactate dehydrogenase (LDH), C-reactive protein (CRP), and cancer antigen 125 (CA125) among cases with OSCC, OLP, and healthy persons. Methods: In this case-control study, salivary markers were evaluated in 55 cases (15 patients with OSCC, 20 patients with OLP, and 20 healthy persons); non-stimulated saliva samples were collected from the patients and saliva markers were measured by the enzyme-linked immunosorbent assay (ELISA) method. The data were analyzed, using SPSS 21 software and ANOVA test and P < 0.05 was regarded as significant. Results: Salivary LDH and CA125 levels were significantly higher in OSCC and OLP patients compared to the control group (P < 0.05). Salivary CRP levels were significantly higher in OSCC patients compared to OLP patients (P < 0.05). Besides, salivary CRP levels were higher in OLP subjects than in the control group, but the difference was not significant (P = 0.56). Conclusions: The identification of the salivary LDH, CA125, and CRP may provide a suitable non-invasive predictive tool for malignant changes. However, its use in clinical practice needs further research. | en |
| DOI | https://doi.org/10.5812/ijcm.108344 | en |
| Keyword | Squamous Cell Carcinoma | en |
| Keyword | Oral Lichen Planus | en |
| Keyword | Saliva | en |
| Keyword | Biomarkers | en |
| Publisher | Brieflands | en |
| Title | Salivary Lactate Dehydrogenase, C-Reactive Protein, and Cancer Antigen 125 Levels in Patients with Oral Lichen Planus and Oral Squamous Cell Carcinoma | en |
| Type | Research Article | en |
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