Real Response to Therapy in Chronic Hepatitis C Virus Patients: A Study From Iran
| Author | Najmeh Namazee | en |
| Author | Shahnaz Sali | en |
| Author | Sorour Asadi | en |
| Author | Mostafa Shafiei | en |
| Author | Bita Behnava | en |
| Author | Seyed Moayed Alavian | en |
| Issued Date | 2012-09-30 | en |
| Abstract | Background: Despite significant advances in the treatment of chronic hepatitis C in the past decades, factors which can affect response rates to combination therapy; peginterferon and ribavirin, are still under study and reaching sustained virological response (SVR) is affected by several different factors. Objectives: To investigate predictor factors contributing to SVR in Iranian patients. Patients and Methods: The present non-randomized, clinical trial was conducted on 100 patients referred to the Tehran Hepatitis Center in 2009-2011. The patients were administered combined peginterferon ?-2a-ribavirin treatment, based on the standard protocol of the Iranian Ministry of Health. At the end of the treatment, the SVR rate and predictors were evaluated. Results: The mean age of the patients was 42 and 78% were male. Genotype 1a was the most common (70%) and 55% of patients were treatment nave. The outcomes showed that 12%, 16% and 22% patients were; non-responders, breakthroughs and relapsers, respectively, while 50% of the patients reached SVR. Patients reaching SVR were aged 40 years or lower, they were less likely to have been a non-responder in prior treatments, more likely to have a non-1a genotype and a higher number had an HCV RNA of less than 600 000 IU/ml. The multivariate analysis showed that an age of 40 or lower (OR = 3.74, CI95% = 1.52-9.22), a non-1a genotype (OR = 3.71, CI 95% = 1.40-9.81) and an HCV RNA less than 600 000 IU/ml (OR = 2.52, CI 95% = 1.03-6.15) may be useful SVR predictors. Conclusions: The findings of the present study showed that half of the patients reached SVR through combined peginterferon ?-2a and ribavirin treatment, the majority of whom had genotype 3a and a minority had genotype 1a. In addition, an age of 40 or lower, non-1a genotype and a viral load less than 600 000 IU/ml were strong SVR predictors. | en |
| DOI | https://doi.org/10.5812/hepatmon.6151 | en |
| Keyword | Hepatitis C | en |
| Keyword | Chronic | en |
| Keyword | Peginterferon Alfa-2a | en |
| Keyword | Ribavirin | en |
| Publisher | Brieflands | en |
| Title | Real Response to Therapy in Chronic Hepatitis C Virus Patients: A Study From Iran | en |
| Type | Research Article | en |
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