Evaluation the Effects of Cissus modeccoides Hot Aqueous Extract on Alloxan-induced Diabetic Rats

Abstract

Introduction: In this study, the hypoglycemic effects and the safety of Cissus modeccoides (CM) were assessed on alloxan‑induced diabetic rats. Methods: Various concentrations of CM hot aqueous extract were orally administered to alloxan‑induced diabetic rats for 30 days. Blood glucose level, hematological and biochemical parameters, and gene expression level were evaluated. Results: After CM treatment, diabetic rats presented nonreduced blood glucose level and unimproved body weight. Increased blood urea nitrogen was observed in CM‑treated groups as well. Although hematological parameters and cholesterol level revealed nonsignificant effects from CM, decreased expression levels of the insulin receptor in the pancreas and insulin receptor substrate 2 and glucose transporter 2 in the liver were demonstrated in CM‑treated groups. Nephrin in the kidney of CM groups was highly expressed. Conclusion: The results of this study revealed adverse effects and toxicity of CM extracts in diabetic rats.