Anti-inflammatory Effect of <i>Aloe vera</i> Extract on Inflammatory Cytokines of Rats Fed with a High-Fat Diet (HFD)
| Author | Nooshin Yazdani | en |
| Author | Seyed Ebrahim Hossini | en |
| Author | Mohammad Amin Edalatmanesh | en |
| Orcid | Nooshin Yazdani [0000-0001-9837-3064] | en |
| Orcid | Seyed Ebrahim Hossini [0000-0003-0548-0114] | en |
| Orcid | Mohammad Amin Edalatmanesh [0000-0002-7936-1145] | en |
| Issued Date | 2022-02-28 | en |
| Abstract | Background: Cytokines are glycoprotein compounds with an important role in inducing and regulating inflammation. Objectives: The present study aimed to measure the effect of Aloe vera alcoholic extracts on inflammatory cytokines in rats fed with a high-fat diet. Methods: Forty adult male Wistar rats were purchased and randomly categorized into five groups, including two control groups (control and control fed a high-fat diet (HFD) and three experimental groups (high-fat diet + 150 mg/kg Aloe vera, high fat diet + 300 mg/kg Aloe vera, and high-fat diet + 600 mg/kg Aloe vera). The rats in the experimental groups received high-fat emulsion and three doses of Aloe vera for 60 days in the form of gavage. Following blood sampling, serum concentrations of tumor necrosis factor-alpha (TNF-α), transforming growth factor-beta (TGF-β), interleukin 6 (IL-6), and interferon-γ (INF-γ) were measured. Statistical analysis was administered using SPSS-20 software by ANOVA test. Mean comparisons were conducted via Duncan’s multiple range test at the 0.05 level of significance. Results: The findings showed that a high-fat diet (HFD) could increase the concentrations of inflammatory factors TNF-α and TGF-β (P < 0.05). Moreover, an increase in the concentration of inflammatory factor IL-6 was observed at P < 0.01. No significant effects were observed in the mean concentration of INF-γ in the study groups. The use of Aloe vera gel extract considerably reduced inflammatory factors TNF-α, TGF-β, and IL-6 in the Aloe vera extract-receiving groups. Conclusions: In general, the results of the present study revealed that Aloe vera alcoholic extract reduced inflammatory factors in the rats fed with a high-fat diet. | en |
| DOI | https://doi.org/10.5812/jjnpp.114323 | en |
| URI | https://brieflands.com/journals/jjnpp/articles/114323 | en |
| Keyword | <i>Aloe vera</i> | en |
| Keyword | Cytokines | en |
| Keyword | High-Fat Diet (HFD) | en |
| Keyword | Inflammation, IL-6, TNF-α | en |
| Publisher | Brieflands | en |
| Title | Anti-inflammatory Effect of <i>Aloe vera</i> Extract on Inflammatory Cytokines of Rats Fed with a High-Fat Diet (HFD) | en |
| Type | Research Article | en |