Lesion scoring and P450 Isoenzyme activity in liver of hepatocarcinogenesis rats treated with Strobilanthes crispus

Abstract

Objective: In this study, we have undertaken efforts to ascertain the anticancer potency of S. crispus (SC) extract on diethylnitrosamine (DEN) and acetylaminofluorene (AAF) induced HCC with special attention to hepatic drug metabolism and to investigate the effect of SC on preneoplastic marker enzyme activity specifically of microsomal aniline hydroxylase (AH) activity and lesion scoring in rats treated with DEN and AAF and controls.