Cardiac Electrophysiological and Functional Findings in Children with Celiac Disease>: An Electrocardiographic and Echocardiographic Study
| Author | Khadijeh Riazi Kermani | en |
| Author | Ali Asgari | en |
| Author | Mahdi Rafizadeh | en |
| Orcid | Khadijeh Riazi Kermani [0000-0003-1932-4331] | en |
| Orcid | Ali Asgari [0000-0002-6800-2921] | en |
| Orcid | Mahdi Rafizadeh [0009-0003-1719-5924] | en |
| Issued Date | 2026-11-30 | en |
| Abstract | Background: Immune-mediated injury in celiac disease (CD) can have consequences beyond the gastrointestinal tract. In children, the extent to which CD is accompanied by measurable changes in cardiac electrical activity or systolic function remains unclear. Objectives: We compared electrocardiographic (ECG) and echocardiographic findings between children with CD and healthy controls and examined whether disease duration or adherence to a gluten-free diet (GFD) was independently associated with cardiac parameters. Methods: The cross-sectional sample comprised 52 children with CD and 50 healthy controls with comparable age and sex distributions. Electrocardiographic assessment included the QT interval, heart-rate-corrected QT interval (QTc), QT dispersion (QTd), T-wave peak-to-end interval (Tp-e), Tp-e/QT and Tp-e/QTc ratios, and P-wave dispersion (PWd). Echocardiography was used to assess left ventricular systolic function, including left ventricular ejection fraction. Within the CD group, disease duration and GFD adherence were examined in separate multivariable linear regression models for each cardiac outcome, with age, sex, and body mass index (BMI) as covariates. Results: Children with CD had a significantly higher heart rate and significant differences in several ECG indices compared with controls. The CD group had higher minimum QT (QTmin), minimum QTc (QTcmin), maximum Tp-e (Tp-e max), Tp-e/QTmax, Tp-e/QTcmax, and PWd values, as well as lower QTd and slightly lower maximum QTc (QTcmax). Left ventricular ejection fraction was modestly lower in children with CD but remained within the physiological range. In adjusted regression analyses, neither disease duration nor GFD adherence was independently associated with the evaluated electrocardiographic or echocardiographic parameters (all P > 0.05). We detected no clinically significant arrhythmia, conduction block, or overt cardiac dysfunction. Conclusions: Children with CD showed subtle electrical and functional cardiac differences; however, these findings were not independently associated with disease duration or current GFD adherence. Larger longitudinal studies are needed to determine their clinical significance. | en |
| DOI | https://doi.org/10.5812/jcp-169242 | en |
| URI | https://brieflands.com/journals/jcp/articles/169242 | en |
| Keyword | Celiac Disease | en |
| Keyword | Electrocardiography | en |
| Keyword | Pediatric Echocardiography | en |
| Keyword | Gluten-free Diet | en |
| Publisher | Brieflands | en |
| Title | Cardiac Electrophysiological and Functional Findings in Children with Celiac Disease>: An Electrocardiographic and Echocardiographic Study | en |
| Type | Research Article | en |
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