Comparative Pharmacokinetics of Baicalin, Wogonoside, Baicalein and Wogonin in Plasma after Oral Administration of Pure Baicalin, <i>Radix Scutellariae and Scutellariae-Paeoniae</i> Couple Extracts in Normal and Ulcerative Colitis Rats
| Author | Zhen-Qiu Zhang | en |
| Author | Wei Liua | en |
| Author | Li Zhuang | en |
| Author | Jing Wang | en |
| Author | Shuai Zhang | en |
| Issued Date | 2013-07-31 | en |
| Abstract | The aim of this study was to investigate the pharmacokinetic profiles of baicalin, wogonoside, baicalein and wogonin after oral administration of pure baicalin, Radix scutellariae and Scutellariae-Paeoniae couple extracts were administered and the pharmacokinetics profiles were compared between normal and ulcerative colitis rats. The plasma concentrations of the four flavonoids were determined by using a simple and rapid high-performance liquid chromatography method. All the rats were divided randomly into two groups (ulcerative colitis and normal groups). Each group contained three subgroups: pure baicalin, Radix scutellariae and Scutellariae-Paeoniae couple extracts subgroup. Each group received oral administration of pure baicalin, Radix Scutellariae and Scutellariae-Paeoniae couple extracts at the same dose of 200 mg/kg baicalin. The results showed that wogonoside, possibily as a methylated product of baicalin, was found in plasma after oral administration of pure baicalin or formulas to rats. Baicalin and wogonoside demonstrated bimodal phenomenon. Baicalin and wogonoside in Scutellariae-Paeoniae couple extract had shown better absorption than which in pure baicalin and Radix Scutellariae extract. Whether oral administration of pure baicalin, Radix Scutellariae or Scutellariae-Paeoniae couple extracts, ulcerative colitis rats showed better absorption than normal rats. For example AUC(0–t) of baicalin were: (41.46 ± 0.62), (59.12 ± 6.42) and (104.87 ± 0.86) (μg/mL)·h in UC groups vs (17.77 ± 0.66), (28.04 ± 4.06) and (49.01 ± 4.61) (μg/mL)·h in normal groups, respectively. The pharmacokinetics properties of the four flavonoids differed between ulcerative colitis and normal rats, including AUC(0–t) and Cmax (p < 0.05). | en |
| DOI | https://doi.org/10.22037/ijpr.2013.1331 | en |
| Keyword | Baicalin | en |
| Keyword | Wogonoside | en |
| Keyword | Baicalein | en |
| Keyword | Wogonin | en |
| Keyword | Pharmacokinetic | en |
| Publisher | Brieflands | en |
| Title | Comparative Pharmacokinetics of Baicalin, Wogonoside, Baicalein and Wogonin in Plasma after Oral Administration of Pure Baicalin, <i>Radix Scutellariae and Scutellariae-Paeoniae</i> Couple Extracts in Normal and Ulcerative Colitis Rats | en |
| Type | Original Article | en |
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