Cytotoxic Flavonoid Glycosides from Rapistrum rugosum L.
| Author | Areej Mohamed Al-Taweel | en |
| Author | Ghada Ahmed Fawzy | en |
| Author | Shagufta Perveen | en |
| Issued Date | 2012-07-31 | en |
| Abstract | Five flavonoid glycosides were isolated from the n-butanol soluble fraction of the ethanolic extract of Rapistrum rugosum and their structures were assigned from 1H- and 13C-NMR spectra (DEPT) with 2D NMR as quercetin-3-O-α-L-rhamnopyranoside (1), quercetin-3-O- β-D-xyloside (2), quercetin, 3-O-α-L-arabinopyranoside,7-O-α-L-rhamnopyranoside (3), kaempferol 3-O-α-L-arabinopyranoside, 7-O-α-L-rhamnopyranoside (4) and rutin (5). The SRB cytotoxic assay was used to investigate the antitumor activities of n-butanol extract, compound 3 and its hexaacetate 3a, for the first time. Compounds 3 and 3a showed cytotoxic activity against the human cancer cell line, namely, HepG2 (hepatocellular carcinoma cell line) with IC50 (concentration of compound required to reduce cell survival by 50%) 0.86 μg/mL and 3.50 μg/mL, respectively. These results proved that compound 3, the major flavonoid of the n-butanol soluble fraction, has significant cytotoxic activity compared with the standard antitumor drug doxorubicin (0.60 μg/mL). | en |
| DOI | https://doi.org/10.22037/ijpr.2012.1116 | en |
| URI | https://brieflands.com/journals/ijpr/articles/125834 | en |
| Keyword | SRB cytotoxic assay | en |
| Keyword | <i>Rapistrum rugosum</i> | en |
| Keyword | Flavonoid glycosides | en |
| Keyword | <i>n</i>-butanol | en |
| Publisher | Brieflands | en |
| Title | Cytotoxic Flavonoid Glycosides from <i>Rapistrum rugosum</i> L. | en |
| Type | Research Article | en |
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