Co-treatment with Vitamin D Supplementation and Aerobic Training in Elderly Women with Vit D Deficiency and NAFLD: A Single-blind Controlled Trial
| Author | Zahra Hoseini | en |
| Author | Nasser Behpour | en |
| Author | Rastegar Hoseini | en |
| Orcid | Zahra Hoseini [0000-0002-7933-2221] | en |
| Orcid | Nasser Behpour [0000-0003-4987-9872] | en |
| Orcid | Rastegar Hoseini [0000-0001-8685-2471] | en |
| Issued Date | 2020-02-15 | en |
| Abstract | Background: Lifestyle intervention is considered first-line therapy for Nonalcoholic Fatty Liver Disease (NAFL). Objectives: Here, we aimed to compare the effect of combined Aerobic Training (AT) and Vitamin D (Vit D) supplementation on NAFLD in elderly women with Vit D deficiency. Methods: We recruited 40 women (60 - 65 years) with NAFLD (second or third grade) and Vit D deficiency. Then, using simple randomization, the subjects were assigned to four groups including aerobic training (AT; 60% - 75%, 20 - 40 min/day, 3 days/wk running and walking), vitamin D supplementation (Vit D; 50,000 IU one day/week), aerobic training plus vitamin D supplementation (AT + Vit D), and sedentary control (C; placebo). The data were analyzed using paired t-test and one-way analysis of variance and Tukey’s post hoc test with SPSS21 at a significance level of P < 0.05. Results: After eight weeks of intervention, fatty liver grade markedly reduced in the AT + Vit D, AT, and Vit D groups (60%, 38.88%, and 22% respectively). However, it increased by 17.60% in the control group. The combination of AT + Vit D significantly reduced liver enzymes, anthropometric indices, and glycemic indices and improved lipid profile. All groups demonstrated a significant inverse correlation between vitamin D and fatty liver grade. Conclusions: A sedentary lifestyle and Vit D deficiency accelerate the NAFLD probably by deteriorating hepatic risk factors. Additionally, adequate levels of plasma vitamin D are necessary to achieve the beneficial metabolic effects of aerobic training. | en |
| DOI | https://doi.org/10.5812/hepatmon.96437 | en |
| Keyword | NAFLD | en |
| Keyword | Vitamin D | en |
| Keyword | Exercise | en |
| Keyword | Liver | en |
| Publisher | Brieflands | en |
| Title | Co-treatment with Vitamin D Supplementation and Aerobic Training in Elderly Women with Vit D Deficiency and NAFLD: A Single-blind Controlled Trial | en |
| Type | Research Article | en |
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