A Comparison of Buccal Midazolam and Intravenous Diazepam for the Acute Treatment of Seizures in Children
| Author | Ali Mazrooei | en |
| Author | Seyed-Hassan Tonekaboni | en |
| Author | Mohammad Ghofrani | en |
| Author | Farhad Mahvelati Shamsabadi | en |
| Issued Date | 2012-09-30 | en |
| Abstract | Objective: The purpose of the present study is to compare efficacy and safety of buccal midazolam with intravenous diazepam in control of seizures in Iranian children. Methods: This is a randomized clinical trial. 92 patients with acute seizures, ranging from 6 months to 14 years were randomly assigned to receive either buccal midazolam (32 cases) or intravenous diazepam (60 cases) at the emergency department of a children's hospital. The primary outcome of this study was cessation of visible seizure activity within 5 minutes from administration of the first dosage. The second dosage was used in case the seizure remained uncontrolled 5 minutes after the first one. Findings: In the midazolam group, 22 (68.8%) patients were relieved from seizures in 10 minutes. Meanwhile, diazepam controlled the episodes of 42 (70%) patients within 10 minutes. The difference was, however, not statistically significant (P=0.9). The mean time required to control the convulsive episodes after administration of medications was not statistically significant (P=0.09). No significant side effects were observed in either group. Nevertheless, the risk of respiratory failure in intravenous diazepam is greater than in buccal midazolam. Conclusion: Buccal midazolam is as effective as and safer than intravenous diazepam in control of seizures. | en |
| DOI | https://doi.org/ | en |
| URI | https://brieflands.com/journals/ijp/articles/2449 | en |
| Keyword | Midazolam | en |
| Keyword | Diazepam | en |
| Keyword | Myoclonic Seizure Disorder | en |
| Keyword | Buccal Drug Administration | en |
| Keyword | Intravenous Injections | en |
| Keyword | Childhood | en |
| Publisher | Brieflands | en |
| Title | A Comparison of Buccal Midazolam and Intravenous Diazepam for the Acute Treatment of Seizures in Children | en |
| Type | Research Article | en |
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