Phytochemical Composition of <i>Rosa foetida</i> Essential Oil and Evaluation of Antioxidant and Anti-oral Squamous Cancer Activities
| Author | Mahsa Rajabi-Moghadam | en |
| Author | Behnam Mahdavi | en |
| Author | Azizollah Habibi | en |
| Author | Mohammad Mahdi Zangeneh | en |
| Author | Akram Zangeneh | en |
| Orcid | Behnam Mahdavi [0000-0002-0427-8339] | en |
| Issued Date | 2025-02-28 | en |
| Abstract | Background: Rosa foetida is a popular plant in Iran due to its various medicinal applications. Objectives: In the present study, the essential oil of R. foetida flowers was isolated to identify the chemical composition and evaluate the anti-oral cancer and antioxidant activity of the plant extract. Methods: The essential oil was extracted using the hydro-distillation method. The GC-MS technique was employed to identify the essential oil composition. The anti-cancer activity of the essential oil against oral squamous cell carcinoma was evaluated using an MTT assay. The antioxidant activity of the hydroalcoholic extract of the plant was evaluated using a DPPH assay. Results: The essential oil was dominated by heneicosane (27.72%), tricosane (24.30%), and nonadecane (14.75%). In the MTT assay, the essential oil exhibited dose-dependent activity against cell lines of HSC-2, HSC-3, HSC-4, and Ca9-22. The highest anticancer activity of R. foetida essential oil was observed against the Ca9-22 cell line with an IC50 of 218 µg/mL. The extract of R. foetida was rich in phenolics, with a total phenolic content of 164 ± 0.67 mg Gallic acid equivalents (GAE)/g. The extract scavenged the free radical of DPPH with an IC50 of 6.54 ± 0.2 µg/mL. Conclusions: The obtained results revealed an acceptable anti-cancer activity against oral squamous cell lines and potent antioxidant activity for the flowers of R. foetida. | en |
| DOI | https://doi.org/10.5812/jjnpp-154003 | en |
| Keyword | Antioxidant Activity | en |
| Keyword | Anti-cancer Activity | en |
| Keyword | Heneicosane | en |
| Keyword | Oral Squamous Cell Carcinoma | en |
| Keyword | <i>Rosa foetida</i> | en |
| Publisher | Brieflands | en |
| Title | Phytochemical Composition of <i>Rosa foetida</i> Essential Oil and Evaluation of Antioxidant and Anti-oral Squamous Cancer Activities | en |
| Type | Research Article | en |