Factors Associated With Changes in Magnesium Levels in Asymptomatic Neonates: A Longitudinal Analysis
| Author | Yogesh Mehta | en |
| Author | Charudatta Shitole | en |
| Author | Maninder Singh Setia | en |
| Issued Date | 2016-02-28 | en |
| Abstract | Background:: Neonates and infants with hypomagnesemia present with seizures and psychomotor delay. Objectives:: The present study evaluated the changes in magnesium (Mg) levels and factors associated with these in the first three days of life. Materials and Methods:: We monitored 50 clinically asymptomatic neonates; they were not given any magnesium supplements even if they had hypomagnesemia at baseline. The variables analysed were: serum Mg; gestational age; birth weight; length; and the ponderal index. We used random effects (RE) models for longitudinal analysis of these data. Results:: The mean standard deviation (SD) gestational age was 36.3 (3.6) weeks and the mean (SD) weight was 2604.2 (754.4) grams. About 31% of the neonates had hypomagnesemia (< 1.6 mg/dL) on day one; however, all had normal magnesium levels by day three of life (P < 0.001). At birth, after adjusting for intrauterine growth retardation status (IUGR), serum Mg levels were lower by 0.0097 mg/dL (95% CI: -0.019 to -0.0003) per 100 grams increase in weight of the neonate. After adjusting for IUGR status, the mean increase in the serum Mg levels was 0.14 mg/dL (95% confidence intervals [CI]: 0.10 to 0.18) per day. The per-day increase in magnesium levels was significantly higher in low birth weight babies (0.10, 95% CI: 0.01 to 0.18) compared with normal birth weight babies. Conclusions:: Asymptomatic neonates may have a high prevalence of hypomagnesemia; however, the levels become normal without any magnesium supplementation. Even though regular monitoring of magnesium levels is useful, no supplements are required - particularly in clinically asymptomatic neonates. | en |
| DOI | https://doi.org/10.5812/ijp.2662 | en |
| Keyword | Magnesium | en |
| Keyword | Supplementation | en |
| Keyword | Hypomagnesemia | en |
| Publisher | Brieflands | en |
| Title | Factors Associated With Changes in Magnesium Levels in Asymptomatic Neonates: A Longitudinal Analysis | en |
| Type | Brief Report | en |
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