Tripartite Motif-Containing 22 Gene -364T/C Polymorphism Associated With Hepatitis B Virus Infection in Chinese Han Population
| Author | Ning Zhao | en |
| Author | Xue-Lian Wang | en |
| Author | Qiu-Hong Gu | en |
| Author | Fen Huang | en |
| Author | Wei Zheng | en |
| Author | Zhi-Wei Li | en |
| Issued Date | 2014-01-01 | en |
| Abstract | Background: Hepatitis B virus (HBV) infection significantly contributes to the onset of liver disease and hepatocellular carcinoma. Understanding the pathogenesis of HBV infection susceptibility could help us to control HBV infection effectively. Objectives: This study investigated single nucleotide polymorphisms (SNPs) of the tripartite motif-containing 22 (TRIM22) gene associated with HBV infection outcome. Patients and Methods: A total of 765 Chinese Han subjects were enrolled: 293 patients were presented with chronic hepatitis B (CHB), 224 were asymptomatic HBV carriers, 248 had self-limited HBV infection, and all of them were recruited for TRIM22 SNPs genotyping. RING and SPRY domains of TRIM22 gene were DNA-sequenced, and HBV serum markers and HBV DNA were measured quantitatively in all subjects. Results: 243 (31.76%) of 765 Chinese Han patients showed genetic variation in the TRIM22 gene. TRIM22 SNPs were mainly in RING area -364T/C site, accounting for 98.35% of the population. There were no significant differences (P > 0.05) in the RING domain -364T/C SNP and allele frequencies between patients with chronic hepatitis and asymptomatic HBV carriers. The CC genotype of TRIM22 gene RING domain -364T/C locus (rs10838543) was associated with chronic HBV infection (OR = 2.30, 95% CI = 1.24-3.97, P = 0.0012; OR = 2.26, 95% CI = 1.08-3.74, P = 0.002) and a mutant allele C carrier of the TRIM22 gene was associated with HBV chronic infection (OR = 1.97, 95% CI = 1.10-3.75, P = 0.0049; OR = 2.12, 95% CI = 1.17-3.89, P = 0.0038). Conclusions: TRIM22 gene RING domain -364T/C polymorphism is associated with chronic HBV infection in Chinese Han population. | en |
| DOI | https://doi.org/10.5812/hepatmon.12110 | en |
| Keyword | <b>Hepatitis B virus</b> | en |
| Keyword | <b>TRIM22 Protein | en |
| Keyword | Human</b> | en |
| Keyword | <b>Polymorphism | en |
| Keyword | Single Nucleotide</b> | en |
| Publisher | Brieflands | en |
| Title | Tripartite Motif-Containing 22 Gene -364T/C Polymorphism Associated With Hepatitis B Virus Infection in Chinese Han Population | en |
| Type | Research Article | en |
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