Assessment of Medication Adherence and Related Factors in Children and Adolescents with Cystic Fibrosis: A Pharmacist-Led Study
| Author | Mahsa Panahishokouh | en |
| Author | Amir Kasaeian | en |
| Author | Saedeh Sadat Jafarrangraz | en |
| Author | Shahideh Amini | en |
| Orcid | Mahsa Panahishokouh [0000-0002-9648-2651] | en |
| Orcid | Amir Kasaeian [0000-0003-2018-9368] | en |
| Orcid | Shahideh Amini [0000-0002-0543-6183] | en |
| Issued Date | 2025-12-31 | en |
| Abstract | Background: Medication non-adherence in cystic fibrosis (CF) can lead to reduced drug efficacy and suboptimal care. Objectives: This study aimed to evaluate adherence to commonly used medications and related factors among children and adolescents with CF. Methods: A research pharmacist assessed drug adherence using the 5-item Medication Adherence Rating Scale (MARS-5) through face-to-face interviews with patients and their parents. Based on the MARS-5 score, patients were categorized as having perfect (≥ 25) or lower (< 25) treatment adherence. Results: A total of 300 patients were included in the study. Between 42.0% and 87.9% of patients were lower-adherent in at least one aspect of their treatment. Among those who received all medications, 86.9% were lower-adherent. Specifically, 42.0% of patients had lower adherence to inhalants, 67.6% to systemic antibiotics, 81.4% to gastrointestinal agents, and 87.9% to nutritional supplements. Factors significantly associated with adherence included the number of drugs for inhalants and systemic antibiotics; the mother’s education level for inhalants, systemic antibiotics, and gastrointestinal agents; and distance from the medical center for inhalants and nutritional supplements (all P < 0.05). Conclusions: Non-adherence to inhalants, systemic antibiotics, gastrointestinal agents, and nutritional supplements is common among children and adolescents with CF. Adherence to one class of medication does not predict adherence to others. A high number of drugs, a low mother’s education level, and a long distance from the medical center decrease the likelihood of perfect adherence to CF medications. | en |
| DOI | https://doi.org/10.5812/jrps-157150 | en |
| Keyword | Compliance | en |
| Keyword | Pediatrics | en |
| Keyword | Pharmacist | en |
| Keyword | Cystic Fibrosis (CF) | en |
| Keyword | Medication Adherence Rating Scale (MARS) | en |
| Publisher | Brieflands | en |
| Title | Assessment of Medication Adherence and Related Factors in Children and Adolescents with Cystic Fibrosis: A Pharmacist-Led Study | en |
| Type | Research Article | en |
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