Enhancement of Frequency Domain Indices of Heart Rate Variability by Cholinergic Stimulation with Pyridostigmine Bromide
| Author | Ali Asghar Zarei | en |
| Author | Seyyed Abbas Foroutan | en |
| Author | Seyyed Mohsen Foroutan | en |
| Author | Abbas Erfanian Omidvar | en |
| Issued Date | 2011-10-31 | en |
| Abstract | Pyridostigmine bromide (PB) is a reversible cholinesterase inhibitor. The aim of this study was to determine the effect of orally administration of single dose sustained-released tablet of pyridostigmine bromide (PBSR) on the frequency domain indices of heart rate variability (HRV). Thirty-two healthy young men were participated in this study. They were divided into 2 groups; the pyridostigmine group (n = 22) and the placebo group (n = 10). Electrocardiogram (ECG) was recorded at 10, 30, 60, 90, 120, 150, 180, 210, 240, 300 and 420 min after PBSR administration. At each time, simultaneously, a blood sample was prepared and PB plasma concentration was measured by high-performance liquid chromatography (HPLC) method. | en |
| DOI | https://doi.org/10.22037/ijpr.2011.987 | en |
| Keyword | Pyridostigmine bromide | en |
| Keyword | Heart rate variability | en |
| Keyword | Cholinergic stimulation | en |
| Keyword | Cholinesterase inhibitors | en |
| Publisher | Brieflands | en |
| Title | Enhancement of Frequency Domain Indices of Heart Rate Variability by Cholinergic Stimulation with Pyridostigmine Bromide | en |
| Type | Original Article | en |
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