Gelatin Microspheres for the Controlled Release of All-trans-Retinoic Acid Topical Formulation and Drug Delivery Evaluation
| Author | Rasool Dinarvand | en |
| Author | Elham Rahmani | en |
| Author | Efat Farbod | en |
| Issued Date | 2003-01-31 | en |
| Abstract | A topical o/w cream containing tretinoin microspheres was prepared. Gelatin microspheres of tretinoin were prepared using coacervation method. These microspheres contained about 50% w/w tretinoin. The particle size range of microspheres was between 90-150 µm. In vitro drug release from microspheres and a cream formulation was studied. It was shown that drug release from microspheres followed Higuchi kinetics of release. However, drug release from the cream formulation followed zero order release profile. | en |
| DOI | https://doi.org/10.22037/ijpr.2010.35 | en |
| Keyword | Topical cream | en |
| Keyword | Zero order release | en |
| Keyword | Coacervation | en |
| Keyword | Gelatin Microspheres | en |
| Keyword | Microencapsulation | en |
| Keyword | Tretinoin | en |
| Keyword | All-trans-retinoic acid | en |
| Publisher | Brieflands | en |
| Title | Gelatin Microspheres for the Controlled Release of All-trans-Retinoic Acid Topical Formulation and Drug Delivery Evaluation | en |
| Type | Research Article | en |
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