Simultaneous Determination of Multicomponent Dosage Forms Using Benchtop NMR Spectroscopy: Application to Phenytoin-Phenobarbital Combination
| Author | Amin Nowroozi | en |
| Author | Mohsen Shahlaei | en |
| Author | Farzad Kobarfard | en |
| Orcid | Farzad Kobarfard [0000-0001-6679-3275] | en |
| Issued Date | 2022-12-31 | en |
| Abstract | The use of nuclear magnetic resonance (NMR) spectroscopy as a tool for determining pharmaceutical molecules in bulk drugs and their dosage forms is growing. New advancements in benchtop NMR spectrometers with cryogen-free magnets have made this technique more appealing and accessible. Herein, we developed a method using a benchtop NMR spectrometer to quantify phenytoin (PhT) and phenobarbital (PhB) in bulk and combined dosage forms. The results were compared to those obtained by high performance liquid chromatography (HPLC) as a well-characterized procedure. This method is simple, low cost, relatively fast, and non-inferior to HPLC in terms of figures of merit. | en |
| DOI | https://doi.org/10.5812/ijpr-127040 | en |
| Keyword | Quantitative NMR | en |
| Keyword | Benchtop NMR | en |
| Keyword | Phenobarbital | en |
| Keyword | Phenytoin | en |
| Keyword | Simultaneous Determination | en |
| Publisher | Brieflands | en |
| Title | Simultaneous Determination of Multicomponent Dosage Forms Using Benchtop NMR Spectroscopy: Application to Phenytoin-Phenobarbital Combination | en |
| Type | Research Article | en |
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