A Diagnostic Scoring System to Distinguish Precocious Puberty from Premature Thelarche based on Clinical and Laboratory Findings
| Author | Murat Karaoglan | en |
| Author | Mehmet Keskin | en |
| Author | Seval Kul | en |
| Author | Ayhan Ozkur | en |
| Issued Date | 2018-06-30 | en |
| Abstract | Background: The diagnosis of patients who present with early pubertal signs can pose a challenge. Objectives: The aim of this study was to design a new diagnostic scoring system based on clinical and laboratory findings to distinguish precocious puberty (PP) from premature thelarche (PT) among girls diagnosed with early puberty. Methods: We enrolled 267 girls (PP, n = 164; PT, n = 103) previously diagnosed with early puberty using GnRH test, retrospectively. A diagnostic scoring model (M) was constructed with five variables and their cut off values were determined for scoring: age of onset (6.5 years), bone age (BA)/choronologic age (CA) ratio (≥ 1.1), estradiol (12 pg/ml), uterine length (32 mm) and ovarian volume (1.09 cm3). Overall score was determined for model. The model was also applied prospectively to a second girls population (n = 86) that showed signs of early puberty. Results: The sensitivity and specificity of model was 89.6% and 87.4%, respectively. In the cohort group, the sensitivity and specificity of model was 90% and 89.4%, prospectively. Conclusions: A diagnostic scoring system, based on clinical and laboratory findings can be an alternative or complementary method for the differential diagnosis of early puberty. | en |
| DOI | https://doi.org/10.5812/ijp.64118 | en |
| Keyword | Early Puberty | en |
| Keyword | Precocious Puberty | en |
| Keyword | Premature Thelarche | en |
| Keyword | Scoring | en |
| Publisher | Brieflands | en |
| Title | A Diagnostic Scoring System to Distinguish Precocious Puberty from Premature Thelarche based on Clinical and Laboratory Findings | en |
| Type | Research Article | en |
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