The Anti-Atherosclerotic Effect of Prosopis Farcta is Associated with the Inhibition of VCAM-1 and ICAM-1
| Author | Gholamreza Bahrami | en |
| Author | Leila Hosseinzadeh | en |
| Author | Zahra Azadi | en |
| Author | Bahareh Mohammadi | en |
| Author | Zahra Mahdiyan | en |
| Author | Marziyeh Hajialyani | en |
| Author | MohammadHossein Farzaei | en |
| Orcid | MohammadHossein Farzaei [0000-0001-7081-6521] | en |
| Issued Date | 2018-12-31 | en |
| Abstract | This study evaluated the anti-atherosclerosis effect of aqueous extract and polysaccharide-enriched fraction of Prosopis farcta on adhesion and inflammatory cascades in vascular endothelial cells and related molecular mechanisms. Cellular toxicities of LPS, plant extract and polysaccharide-enriched fraction were analyzed in vitro using the MTT method. The ROS accumulation, mRNA expression of ICAM1 and VCAM1, and COX activity were measured in HUVEC cells. These results revealed a new underlying mechanism for anti-atherosclerosis effect of P. farcta and polysaccharide-enriched fraction by attenuating inflammatory cascade mediated by COX expression, modulating expression of cell-adhesion molecules including VCAM-1 and ICAM-1, and diminishing oxidative stress agents. | en |
| DOI | https://doi.org/ | en |
| Keyword | Atherosclerosis | en |
| Keyword | Adhesion Molecules | en |
| Keyword | cytotoxicity | en |
| Keyword | HUVEC | en |
| Keyword | LPS | en |
| Keyword | Prosopis Farcta | en |
| Publisher | Brieflands | en |
| Title | The Anti-Atherosclerotic Effect of Prosopis Farcta is Associated with the Inhibition of VCAM-1 and ICAM-1 | en |
| Type | Research Article | en |