Prevalence of Odontogenic Tumors and Cysts in Iran: A Systematic Review and Meta-analysis

Abstract

Context: Odontogenic tumors and cysts (AOD) have a significant prevalence in Iran and have many negative effects on patients' health. Objectives: The aim of the study is to investigate the prevalence of odontogenic cysts and tumors in Iran with a systematic review and meta-analysis method. Methods: In this meta-analysis study, which was conducted using the PRISMA checklist, all published articles (2000 - 2024) on the prevalence of AOT and oral cancers (OCs) were included in the study. The information search was conducted by two researchers specializing in oral and dental diseases (in domestic Iranian and international databases). Articles published in Iran, in which the prevalence or the number of AOT and OCs were reported, were included in the study. Systematic review studies and case reports were excluded from the study. The researchers used a checklist containing items such as the number of anatomical locations of odontogenic (Maxilla and Mandible), the number of odontogenic tumors, the number of odontogenic cysts, and the total number of patients. An analysis was done using the software CMA. Results: Result showed in 1043 articles found in the initial search, 26 articles were entered into the meta-analysis stage, and data analysis was conducted for them. The prevalence of AOD was 0.124 (CI = 0.121 - 0.126) based on the Fixed analysis model and 0.067 (CI = 0.097 - 0.046) in the random analysis model. Also, based on the Random model, the prevalence of Odontogenic cysts was equal to 0.111 (CI = 0.085 - 0.144) and the prevalence of Odontogenic tumors was equal to 0.023 [CI = 0.012 - 0.040]. Conclusions: Since the prevalence of odontogenic cysts and tumors was significant in this meta-analysis study, it is suggested to take necessary measures and screening for the prevention of AOT and OCs.