Evaluation of the Protective Effect of Hydroalcoholic and Aqueous Extracts of <i>Ulmus minor</i> Leaves on Ulcerative Colitis Induced by Acetic Acid in Rats
| Author | Shireen Jalal | en |
| Author | Sajad Fakhri | en |
| Author | Mohammad Reza Morovati | en |
| Author | Ehsan Mohammadi Noori | en |
| Author | Shahram Miraghaee | en |
| Author | Mohammad Hosein Farzaei | en |
| Orcid | Sajad Fakhri [0000-0001-8265-8284] | en |
| Orcid | Mohammad Hosein Farzaei [0000-0001-7081-6521] | en |
| Issued Date | 2024-11-30 | en |
| Abstract | Background: Ulcerative colitis (UC) is a chronic inflammatory disease of the large intestine that cannot be cured, but its symptoms can be managed. Objectives: This study aimed to evaluate the protective effects of hydroalcoholic and aqueous extracts of Ulmus minor leaves on UC induced by acetic acid in rats. Methods: Rats were randomly divided into seven groups of five, and 3% acetic acid was used to induce colitis. To assess the protective effect of Ulmus minor leaves, macroscopic, microscopic, and histological evaluations were performed on the different study groups. Results: Macroscopic examinations of both the hydroalcoholic and aqueous extract groups showed that the aqueous extract at a dose of 200 mg/kg provided the best protective effect on colon tissue. Rats treated with hydroalcoholic extracts at doses of 100 mg/kg and 200 mg/kg, as well as those treated with aqueous extract at 100 mg/kg, also showed favorable outcomes compared to the control group, with a significant difference (P < 0.05). Furthermore, among the groups treated with hydroalcoholic and aqueous extracts, the aqueous extract at 200 mg/kg demonstrated the most protective effects based on microscopic and histological evaluations of the colon. Conclusions: The extracts of Ulmus minor leaves demonstrated anti-inflammatory properties in an animal model of colitis. Further studies are required to evaluate their potential therapeutic benefits in patients with UC. | en |
| DOI | https://doi.org/10.5812/jjnpp-142668 | en |
| Keyword | Acetic Acid | en |
| Keyword | Colitis | en |
| Keyword | Rat | en |
| Keyword | Inflammation | en |
| Keyword | <i>Ulmus minor</i> Leaves | en |
| Publisher | Brieflands | en |
| Title | Evaluation of the Protective Effect of Hydroalcoholic and Aqueous Extracts of <i>Ulmus minor</i> Leaves on Ulcerative Colitis Induced by Acetic Acid in Rats | en |
| Type | Research Article | en |