Association Study of rs2987983 Polymorphism in the Promoter Region of <i>ESR2</i> Gene and Susceptibility to Nodular Thyroid in Women of Markazi Province, Iran
| Author | Maryam Yousefi | en |
| Author | Ahmad Hamta | en |
| Author | Abdorrahim Sadeghi | en |
| Author | Mehrdad Hashemi | en |
| Author | Afsaneh Talaii | en |
| Author | Masood Fazeli Mosleh Abadi | en |
| Author | Fatemeh Mohammadi | en |
| Orcid | Ahmad Hamta [0000-0003-4681-4731] | en |
| Orcid | Mehrdad Hashemi [0000-0003-0627-6991] | en |
| Issued Date | 2021-06-30 | en |
| Abstract | Background: The risk of thyroid disease has been increased during recent years; more than 200 million people are suffering from various types of thyroid diseases. The rate of thyroid nodules in women is 4 times more than that of men. Epidemiological findings and experimental evidence of thyroid lesions suggest that sex hormones, especially estrogen, may affect this gland and its neoplasms. Objectives: Considering the prevalence of benign and malignant thyroid disease in women, we investigated the association between rs2987983 polymorphism in the estrogen receptor beta gene and nodular thyroid disease. Methods: In this case-control study, 146 patients with thyroid nodules from Amir- Almomenin Hospital in Arak were compared with 151 healthy individuals. The diagnosis was performed by ultrasonography and confirmed by an endocrinologist. After DNA extraction, genotyping was performed with T-ARMS PCR. Finally, statistical analysis was carried out. Results: The frequencies of AA, AG, and GG genotypes in the case group were 48 (32.9%), 83 (56.8%), and 15 (10.3%), respectively. These values in the control group were 64 (42.4%), 64 (42.4%), and 23 (15.2%), respectively. Overall, a statistically significant association (P = 0.042, χ2 = 6.3, df = 2) was observed between rs2987983 polymorphism and thyroid nodules. Conclusions: Considering the significant association between rs2987983 polymorphism and thyroid nodules, it can be suggested that the mentioned polymorphism may be used as a diagnostic biomarker. Because this polymorphism is in the promoter region of the gene, it probably alters gene expression levels. | en |
| DOI | https://doi.org/10.5812/ijcm.66753 | en |
| Keyword | Nodular Thyroid | en |
| Keyword | Polymorphism | en |
| Keyword | rs2987983 | en |
| Keyword | Estrogen Receptor Beta | en |
| Publisher | Brieflands | en |
| Title | Association Study of rs2987983 Polymorphism in the Promoter Region of <i>ESR2</i> Gene and Susceptibility to Nodular Thyroid in Women of Markazi Province, Iran | en |
| Type | Research Article | en |