Survival and Recurrence Rate in Patients with Head and Neck Cancer and Associated Prognostic Factors
| Author | Elaheh Talebi Ghane | en |
| Author | Ahmad Reza Baghestani | en |
| Author | Farid Zayeri | en |
| Author | Ideh Talimkhani | en |
| Author | Sahar Masoudi | en |
| Orcid | Ahmad Reza Baghestani [0000-0003-2813-6762] | en |
| Orcid | Farid Zayeri [0000-0002-7791-8122] | en |
| Issued Date | 2018-08-31 | en |
| Abstract | Background: Head and Neck cancer (HNC) is the 6th most common cancer worldwide. Its recurrence probability is known as the greatest obstacle to prolong survival rate. Objectives: This study was conducted to assess survival and recurrence rate of HNC and their associated risk factors. Methods: This retrospective cohort study was conducted on 179 HNC patients, who were diagnosed from April 2007 to November 2013 in Tehran, Iran. Two outcomes were simultaneously analyzed: time between diagnosis and disease recurrence or inter-recurrences; the time between diagnosis and death or end of the study. Kaplan-Meier curve, log-rank test, and general joint frailty model were utilized to data analysis, using Stata 11.0 and R. Results: From 179 patients, 52.5% experienced relapse at least once and 15.6% of cases deceased. The survival rate in 12-, 24-, and 60- month were 94.4, 83.1%, and 55.4%, respectively. The median of survival time was 60.92 (1.1 - 72.9) months, which was longer in patients with relapse (63.62 versus 24.16). Advanced stage and the age older than 50 significantly increased the risk of death about 4-fold and 3-fold (P = 0.007, P = 0.014). Moreover, the initial treatment of surgery + radiotherapy + chemotherapy had significantly raised the hazard of relapse (P < 0.001). Conclusions: The percentage of deceased patients in relapse group was more than non-relapses, but the median of survival time in them was longer. Early detection can prevent recurrent events and the premature death of HNC patients. | en |
| DOI | https://doi.org/10.5812/ijcm.12794 | en |
| Keyword | Head and Neck Neoplasms | en |
| Keyword | Survival | en |
| Keyword | Recurrence | en |
| Keyword | Joint frailty model | en |
| Publisher | Brieflands | en |
| Title | Survival and Recurrence Rate in Patients with Head and Neck Cancer and Associated Prognostic Factors | en |
| Type | Research Article | en |
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