The Contribution of <i>VKORC1</i> and <i>CYP2C9 </i>Genetic Polymorphisms and Patients’ Demographic Characteristics with Warfarin Maintenance Doses: A Suggested Warfarin Dosing Algorithm
| Author | Esmat Khaleqsefat | en |
| Author | Mohammad Khalaj-Kondori | en |
| Author | Mortaza Jabarpour Bonyadi | en |
| Author | Hamid Soraya | en |
| Author | Behnam Askari | en |
| Issued Date | 2020-07-31 | en |
| Abstract | The requirement of varying doses of warfarin for different individuals can be explained by environmental and genetic factors. We evaluated the frequency of vitamin K epoxide reductase complex subunit 1 (VKORC1) and cytochrome P450 2C9 (CYP2C9) variants together with patientdemographic characteristics and investigated their association with warfarin dose requirement with the objective to suggest a warfarin dosing algorithm. In this study, 185 patients with heart valve replacement from West Azerbaijan, Iran were genotyped for VKORC1 (-1639 G>A) and CYP2C9 (*2 and *3 alleles) by PCR-RFLP. Multiple linear regression was performed to create a new warfarin dosing algorithm. The frequency of variants in studied subjects was 12% for CYP2C9 *2, 25.8% for CYP2C9 *3, and 60% for -1639A. The patients who carried the A allele at position -1639 VKORC1 and the variants CYP2C9 *2 and *3 required a significantly lower daily mean warfarin dosage (P = 0.001). Statistical analysis also indicated a significant relationship between the daily maintenance dose of warfarin with age and blood pressure among the studied patients’ cohort (P < 0.001). This study showed that in the heart valve replacement patients considering VKORC1 and CYP2C9 polymorphisms beside demographic characteristics such as age will be helpful in pre-treatment dosing of warfarin which in turn reduces the complications associated with inappropriate warfarin dosing. | en |
| DOI | https://doi.org/10.22037/ijpr.2020.1101116 | en |
| Keyword | VKORC1 | en |
| Keyword | CYP2C9 | en |
| Keyword | Genetic Polymorphism | en |
| Keyword | Warfarin | en |
| Keyword | Demographic Characteristics | en |
| Publisher | Brieflands | en |
| Title | The Contribution of <i>VKORC1</i> and <i>CYP2C9 </i>Genetic Polymorphisms and Patients’ Demographic Characteristics with Warfarin Maintenance Doses: A Suggested Warfarin Dosing Algorithm | en |
| Type | Original Article | en |
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