Bruton’s Disease Presenting With Arthritis; A Case Report

Abstract

Introduction:: X-linked Agammaglobulinemia (XLA) is one of the primary humoral immunodeficiencies. It usually presents symptoms of recurrent infections, but in some unusual cases it may present rheumatologic manifestations. Case Presentation:: The current paper presents the cases of two boys with arthritis treated for juvenile rheumatoid arthritis (JRA) without proper responses. Addition of some recurrent infections in the course of their disease led to work-up them for immunodeficiencies. Conclusions:: According to the results of these work-ups, XLA was diagnosed for the cases.