Place Aversion by Morphine in Offspring Born of Female Morphine Administered Wistar Rats
| Author | Manizheh Karami | en |
| Author | Mohammad Reza Zarrindast | en |
| Issued Date | 2011-07-31 | en |
| Abstract | This research was designed to study sexual differences in place conditioning induced by morphine in offspring born of female Wistar rats mated with drug-naïve males. Mothers were exposed to morphine during the 14th-16th days of gestational. Control dams were simply saline-injected. Female and male virgin offspring born of morphine-treated or saline-treated mothers were separately housed until become fully matured. A 3-day schedule of an unbiased conditioning procedure was used to the induce conditioning to morphine (2.5-7.5 mg/Kg, SC) in the offspring. According to the results, female offspring born of saline-administered mothers were morphine place-conditioned at lower doses of opioid (2.5 mg/Kg) in comparison to the males. An increase in locomotor activity in the females at 7.5 mg/Kg of opioid was also revealed. In contrast, administration of morphine (2.5-7.5 mg/Kg, SC), induced a significant aversion in either sexes of offspring born of morphine-exposed mothers. Moreover, female offspring of this category acquired more pronounced aversion at higher doses of morphine than males. In addition, a significant morphine-dose effect (7.5 mg/Kg, SC) on locomotor activity of these females’ offspring was observed. This study may highlight sex differences in conditioning effects induced by morphine between offspring derived of morphine-treated mothers and those of saline-treated. | en |
| DOI | https://doi.org/10.22037/ijpr.2011.1000 | en |
| URI | https://brieflands.com/journals/ijpr/articles/125959 | en |
| Keyword | Morphine | en |
| Keyword | Sex-dependent | en |
| Keyword | Place conditioning | en |
| Keyword | Aversion | en |
| Keyword | Pregnancy | en |
| Keyword | Offspring (rat) | en |
| Publisher | Brieflands | en |
| Title | Place Aversion by Morphine in Offspring Born of Female Morphine Administered Wistar Rats | en |
| Type | Original Article | en |
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