Factors Associated with Newborn Fatality Due to Persistent Pulmonary Hypertension
| Author | Kang Zeng | en |
| Author | A-Juan Huang | en |
| Author | Yun-Xia Sun | en |
| Author | Jin Zhong | en |
| Author | Man-Li Zheng | en |
| Author | You-Qun Zou | en |
| Author | Xin Sun | en |
| Author | Yu-Mei Liu | en |
| Issued Date | 2023-04-30 | en |
| Abstract | Objectives: This study is designed to explore factors associated with death in newborns with persistent pulmonary hypertension (PPHN). Methods: The clinical data of PPHN cases in the past ten years from a neonatal center in China were retrospectively collected and analyzed, and the death-related factors attributable to PPHN were analyzed by binary stepwise logistic regression analysis. Results: A total of 161 neonates with PPHN were included in this study, with a mortality rate of 18.0% (29/161). Multivariate binary logistic regression analysis indicated that cesarean delivery was negatively associated with death in infants with PPHN (adjusted odds ratio [OR] = 0.289, 95% confidence interval [CI] 0.104 – 0.803), while premature rupture of membranes (PROM) (adjusted OR = 4.032, 95% CI 1.32 - 12.32), congenital lung developmental abnormalities/congenital diaphragmatic hernia (CDH) (adjusted OR = 12.65, 95% CI 1.088 – 147.068), respiratory distress syndrome (RDS) (adjusted OR = 4.802, 95% CI 1.512 – 15.251), inhaled nitric oxide (iNO) (adjusted OR = 12.377, 95% CI 3.22 – 47.576) and norepinephrine (adjusted OR = 2.891, 95% CI 1.03 – 8.118) were the independent factors associated with a higher risk of death from PPHN. Conclusions: Caesarean delivery with medical indication is an independent protective factor against death in neonates with PPHN. PROM, congenital lung developmental abnormalities/CDH, RDS, iNO, and norepinephrine were independent death-related factors in neonates with PPHN. | en |
| DOI | https://doi.org/10.5812/ijp-132747 | en |
| Keyword | Persistent Pulmonary Hypertension | en |
| Keyword | Infant | en |
| Keyword | Newborn | en |
| Keyword | Risk Factors | en |
| Keyword | Vascular Resistance | en |
| Publisher | Brieflands | en |
| Title | Factors Associated with Newborn Fatality Due to Persistent Pulmonary Hypertension | en |
| Type | Research Article | en |
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