Evaluation of 24 Bp Duplication of Chitotriosidase Gene in Pulmonary Tuberculosis in Zahedan, Southeast Iran: A Preliminary Report
| Author | Mohammad Naderi | en |
| Author | Mohammad Hashemi | en |
| Author | Shadi Amininia | en |
| Author | Maryam Rezaei | en |
| Author | Mohsen Taheri | en |
| Orcid | Mohammad Hashemi [0000-0002-6074-7101] | en |
| Issued Date | 2015-10-01 | en |
| Abstract | Background: Chitotriosidase (CHIT1), the major chitinase in human airways, is expressed by pulmonary macrophage. Variation in the coding region with 24 bp duplication allele results in reduced CHIT1 activity. Objectives: The present study was designed to assess the impact of 24 bp duplication in exon 10 of human CHIT1 gene on pulmonary tuberculosis (PTB) risk. Patients and Methods: This case-control study was performed on 173 PTB patients and 164 healthy subjects in Zahedan, southeast Iran. Polymerase chain reaction (PCR) was used to detect the variant. Results: Homozygous wild type, heterozygous and homozygous mutant frequencies of CHIT1 24 bp duplication polymorphism were 43.9%, 43.9% and 12.2% in controls and 42.8%, 45.1% and 12.1% in PTB patients. We found the mutant allele frequency of 34.2% and 34.7% in controls and cases, respectively. Chi-square comparison of PTB and control subjects and logistic regression analysis revealed no association between CHIT1 24 bp duplication and PTB. Conclusions: In conclusion, CHIT1 24 bp duplication might not be a candidate gene for susceptibility to PTB. Larger studies are necessary to confirm these findings in various populations. | en |
| DOI | https://doi.org/10.5812/archcid.25178 | en |
| Keyword | Pulmonary Tuberculosis | en |
| Keyword | Chitinase | en |
| Keyword | Gene Duplication | en |
| Keyword | Polymorphism | en |
| Keyword | Genotype | en |
| Publisher | Brieflands | en |
| Title | Evaluation of 24 Bp Duplication of Chitotriosidase Gene in Pulmonary Tuberculosis in Zahedan, Southeast Iran: A Preliminary Report | en |
| Type | Research Article | en |
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