Manganese and Iron Binding to Human Transferrin
| Author | Ali Asghar Moshtaghie | en |
| Author | Akbar Badii | en |
| Author | Mohammad Fazilati | en |
| Author | Taghi Hassanzadeh | en |
| Author | Hadi Kharazi | en |
| Issued Date | 2007-04-30 | en |
| Abstract | The characteristics of manganese and iron binding to human apotransferrin (apo-tf) have been investigated and compared in this study. Both metal ions were taken up by human apo-tf and formed complexes, with the maximum absorbances observed at 410 and 340 nm for manganese-transferrin (Mn-tf) and 465 nm for iron-transferrin (Fe-tf). Addition of manganese (1.5 µg/ml) to the reaction mixture containing iron and apo-tf, reduced Fe binding to apo-tf by 20 percent, in comparison to the control sample. The binding of both metals to apo-tf appears to be time and pH dependent processes. | en |
| DOI | https://doi.org/10.22037/ijpr.2010.706 | en |
| Keyword | Binding activity | en |
| Keyword | Transferrin | en |
| Keyword | iron | en |
| Keyword | Manganese | en |
| Publisher | Brieflands | en |
| Title | Manganese and Iron Binding to Human Transferrin | en |
| Type | Research Article | en |
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