Formulation and Evaluation of Langsat (Lansium domesticum Corr.) Peel Ethanol extracts Lotion as Anti-Mosquito Repellent

Abstract

The repellent is a material that works in protecting humans from mosquito bites. Langsat peel (Lansium domesticum Corr.) is one of the plants having function as repellent, anti-mosquito containing triterpenoid compound. The purpose of this research was to formulate the langsat peel ethanol extract into anti-mosquito lotion and to determine the effectiveness of repellent anti-mosquito from the best formulation of the langsat peel ethanol extract. The Optimization of the lotion basis was performed on three variations of cetyl alcohol concentrations i.e. 3%, 5%, and 7% respectively and obtained F2 containing 5% Cetyl alcohol as the optimum base. The F2 lotion basis formula was formulated into lotion with three concentrations of 10%, 20%, and 35%. The three lotions formula of the langsat peel ethanol extract was tested by organoleptic test, preparation, spreading test, adhesion test and stability test, including pH and viscosity exposed at 15-30oC, 4oC and 40oC. All formulas were tested for irritation using rabbits for 3 days and did not show any erythema and edema. Tests of the effectiveness of anti-mosquito were done on rabbit using mosquitoes. The results obtained showed that langsat peel extract 20% and 35% had effectiveness as anti-mosquito repellent and can be formulated into lotion dosage form.