<i>Clostridium difficile</i> Infection Among Hospitalized Chronic Hepatitis B Virus-Infected Patients in a Chinese Hospital
| Author | Yunbo Chen | en |
| Author | Qiaodi Gui | en |
| Author | Qiaomai Xu | en |
| Author | Tao Lv | en |
| Author | Silan Gu | en |
| Author | Ping Shen | en |
| Author | Jiazheng Quan | en |
| Author | Yunhui Fang | en |
| Author | Guangyong Ye | en |
| Author | Lanjuan Li | en |
| Issued Date | 2018-09-30 | en |
| Abstract | Background: Liver disease represents a risk factor for Clostridium difficile infection (CDI). However, CDI predisposition and its incidence in patients with chronic hepatitis B (CHB) have not been well-characterized. Objectives: This study aimed at determining the incidence and risk factors of CDI in CHB patients without cirrhosis. Methods: A retrospective case-control study was conducted on hospitalized patients in a Chinese tertiary hospital between June 2010 and June 2016. Results: A total of 105 CHB patients without cirrhosis were included in the present study. Among these patients, 35 (33%) patients developed hospital-acquired CDI. A total of 35 toxigenic C. difficile strains were assigned to 15 different STs by multi-locus sequence typing (MLST). Multivariate analysis indicated that prolonged hospital stay (OR: 1.045; 95% CI: 1.006 to 1.086) and higher Charlson scores on admission (OR: 3.063; 95% CI: 1.602 to 5.857) were independent factors for the development of CDI among CHB patients without cirrhosis. Conclusions: A high incidence of CDI was detected in this cohort of CHB patients. Both the prolonged hospital stay and higher Charlson scores made CHB patients more susceptible to hospital-acquired CDI. Greater emphasis on infection control measures and antimicrobial stewardship in patients with CHB during hospital admission is needed. | en |
| DOI | https://doi.org/10.5812/jjm.68809 | en |
| Keyword | Infection | en |
| Keyword | Hepatitis B Virus | en |
| Keyword | <i>Clostridium difficile</i> | en |
| Publisher | Brieflands | en |
| Title | <i>Clostridium difficile</i> Infection Among Hospitalized Chronic Hepatitis B Virus-Infected Patients in a Chinese Hospital | en |
| Type | Research Article | en |
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