Synthesis, Characterization and Cytotoxicity of Alkylated Quercetin Derivatives
| Author | Xin-Ran Bao | en |
| Author | Han Liao | en |
| Author | Jiao Qu | en |
| Author | Yong Sun | en |
| Author | Xin Guo | en |
| Author | En-Xia Wang | en |
| Author | Yu-Hong Zhen | en |
| Issued Date | 2016-07-31 | en |
| Abstract | Quercetin, a ubiquitous flavonol, represents a promising leading drug for development of new chemotherapeutic agents. However, its limited cytotoxicity to cancer cells hampers its clinical use. In order to obtain novel quercetin derivatives with superior cytotoxicity, seven alkylated quercetin derivatives were synthesized. Solubility of these derivatives was determined by turbidimetry. Cytotoxicity of the high-soluble derivatives against MCF-7 cells and caco-2 cells was determined using MTT assay. Among these seven products, 7-O-butylquercetin had the highest solubility in DMEM medium and 7-O-geranylquercetin had the most potent cytotoxicity. Further study on cytotoxicity of 7-O-geranylquercetin on NCI-H446, A549, MGC-803 and SGC-7901 cell lines revealed potential antiproliferative effects. The 7-O-geranylquercetin is a broad spectrum cytotoxic agent and it may be a promising leading drug for cancer chemotherapy. | en |
| DOI | https://doi.org/10.22037/ijpr.2016.1877 | en |
| Keyword | Quercetin | en |
| Keyword | Alkyl derivatives | en |
| Keyword | Cytotoxicity | en |
| Keyword | Selective alkylation | en |
| Publisher | Brieflands | en |
| Title | Synthesis, Characterization and Cytotoxicity of Alkylated Quercetin Derivatives | en |
| Type | Original Article | en |