Twenty-Year Trends in HBsAg Seroprevalence and Associated Risk Factors Among Blood Donors in Sistan and Baluchestan, Iran (2005 - 2024)
| Author | Abolhasan Safdari | en |
| Author | Alireza Ansari Moghaddam | en |
| Author | Soheila Khosravi | en |
| Author | Mahdi Zarourati | en |
| Orcid | Abolhasan Safdari [0000-0001-6793-1596] | en |
| Orcid | Alireza Ansari Moghaddam [0000-0002-3267-7193] | en |
| Orcid | Soheila Khosravi [0000-0002-1820-850X] | en |
| Orcid | Mahdi Zarourati [0009-0008-9749-6466] | en |
| Accessioned Date | 2026-07-29T06:16:16Z | |
| Issued Date | 2026-12-31 | en |
| Abstract | Background: Long-term surveillance of transfusion-transmitted infections is essential, particularly in border regions. Objectives: This study analyzed 20-year trends in hepatitis B virus (HBV) seroprevalence and associated risk factors among blood donors in Sistan and Baluchestan Province, Iran, from 2005 to 2024. Methods: This retrospective analysis included 935,864 blood donors. Screening methods evolved from manual enzyme-linked immunosorbent assay (ELISA; 2005 - 2009) to automated ELISA beginning in 2009, chemiluminescence immunoassay (CLIA) beginning in 2019, and nucleic acid testing (NAT) beginning in 2024. A nested case-control study of 300 HBsAg-positive and 300 HBsAg-negative donors was analyzed using multivariable logistic regression. Results: The overall HBsAg seroprevalence was 0.634% (5,930/935,864). Annual prevalence declined from 2.039% in 2005 to 0.189% in 2024 (relative reduction > 90%; P < 0.001), reaching a minimum of 0.019% in 2019. First-time donors had a higher prevalence than repeat donors (1.861% vs 0.021%; P < 0.001). Independent risk factors included household contact with an HBV-infected person (adjusted odds ratio [aOR] = 54.5), drug abuse (aOR = 19.4), a history of jaundice (aOR = 8.1), and knife wounds (aOR = 7.3). Higher education was a protective factor. Conclusions: HBsAg seroprevalence decreased by more than 90% over two decades, reflecting the success of national vaccination and donor-selection strategies. Expanding the repeat-donor pool and maintaining NAT are essential for further improving blood safety. | en |
| DOI | https://doi.org/10.5812/hepatmon-172664 | en |
| URI | https://brieflands.com/journals/hepatmon/articles/172664 | en |
| URI | https://repository.brieflands.com/handle/123456789/68052 | |
| Keyword | Hepatitis B Virus | en |
| Keyword | HBsAg | en |
| Keyword | Blood Donors | en |
| Keyword | Seroprevalence | en |
| Keyword | Blood Safety | en |
| Publisher | Brieflands | en |
| Title | Twenty-Year Trends in HBsAg Seroprevalence and Associated Risk Factors Among Blood Donors in Sistan and Baluchestan, Iran (2005 - 2024) | en |
| Type | Research Article | en |
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