Purification of Hyaluronan Binding Proteins from Human Normal and Cancer Serum

Abstract

Background: Analysis of human cancer serum has revealed the presence of high amounts of hyaluronan (hyaluronic acid, HA) when compared to human normal serum, It is well documented that HA and its receptors, known as hyaladherins (HABPs) are involved in matrix regulation, cell proliferation, migration and at the matrix proper but also with hyaluronan at the plasma membrane as a cell surface receptors and thus influence cell physiology including secretion of this protein into the circulatory system.