Brieflands

History

The company was first founded by Seyyed M. Miri and Seyed-M Alavian as an editorial group in a Medical Institute in 2007 to publish its medical journal. After three years of experience, the number of journals increased to 5 journals, and the company launched its first form of business as a VOF (collaboration) professional STM company in Heerlen, the Netherlands, which was called "Kowsarmedical Publishing." Respecting the publishing services (from submission to publishing), especially an in-house "Journal Management System," our journals increased to more than 60 STM journals between 2010 and 2019. Since 2022, "Brieflands" is the new brand name that acts as a "Science, Technical, Medical Publisher" that publishes more than 50 journals with the services provided by 97 expert employees in three different branches.

Business Profile

Brieflands is a Registered Trademark with record number 1454012.
Brieflands has been registered as a General partnership (Vennootschap onder firma) company in the Chamber of Commerce (Kamer van Koophandel) of the Netherlands since 2010.
- KvK number: 89235444.
- BTW (VAT) number: NL864918896B01 (check online at VIES )
- RSIN: 864918896
Nedmedica is our related company which is specialized in Author Services.
Our former branding name was Kowsarmedical Publishing (2010-2021).

Communities in Brieflands

Select a community to browse its collections.

Recent Submissions

Treatment Non-Adherence in Type 2 Diabetes: A Qualitative Content Analysis from the Perspectives of Patients, Their Families, Physicians, and Healthcare Providers
(Brieflands, 2026-12-31)
Zahra Kashi
;
Mojgan Geran
;
Naiereh Aghaei
;
Razieh Fallah
;
Hamideh Mohammadi-Berenjestanaki
Background: With the rising global prevalence of type 2 diabetes and its complications, achieving glycemic control through adherence to treatment is a key goal of disease management. However, numerous socioeconomic, behavioral, and cultural factors adversely affect adherence. Objectives: This study aimed to elucidate the factors contributing to treatment nonadherence among patients with type 2 diabetes from the perspectives of patients, their families, and health care providers. Methods: A conventional qualitative content analysis based on the Graneheim and Lundman framework was conducted in Sari, northern Iran, from March to July 2025. Participants were purposively selected from Emam Hospital and health centers and included 6 physicians, 8 patients, 2 family members, and 5 healthcare providers. Data were collected through in-depth, semistructured interviews until saturation was reached. MAXQDA 10 software was used for data management. Results: The findings were organized into 3 categories and 7 subcategories: structural-institutional factors (service delivery challenges and economic challenges), sociocultural factors (gender inequalities, cultural norms, and weak support structures), and personal factors (cognitive barriers and implementation barriers). Conclusions: Treatment nonadherence in diabetes is shaped by structural-institutional, sociocultural, and personal barriers. Effective management is possible through a holistic approach that addresses these factors.
Factors Associated with Open Thoracic Surgery in Children with Pleural Effusion: A Retrospective Observational Study
(Brieflands, 2026-11-30)
Farinaz Amirikar
;
Nemat Bilan
;
Amirmahmoud Erfani
;
Saeid Aslanabadi
;
Sajjad Pourasghary
Background: Pleural effusion may complicate pediatric respiratory disease and occasionally necessitate open thoracic surgery despite medical or minimally invasive management. Evidence regarding clinical and biochemical characteristics specifically associated with open thoracic surgery in children remains limited. Objectives: To identify demographic, clinical, imaging, laboratory, and preadmission medication factors associated with open thoracic surgery in hospitalized children with pleural effusion. Methods: This retrospective observational study included children older than 1 month and younger than 18 years who were treated for pleural effusion at Zahra Mardani Azari Children's Hospital, Tabriz, Iran, between March 2023 and March 2024. The primary outcome was open thoracic surgery, defined as thoracotomy with decortication, segmentectomy, or lobectomy. The comparison group included children managed without open thoracic surgery. Between-group comparisons and logistic regression were used to examine associations, which are reported as odds ratios (ORs) and 95% confidence intervals (CIs). Results: Of the 83 children, 34 (41.0%) underwent open thoracic surgery and 49 (59.0%) did not. Severe imaging-assessed pleural effusion was more common in the open thoracic surgery group (55.9% vs. 28.6%; P = 0.024), and hospitalization was longer (19.1 ± 11.0 vs. 12.9 ± 5.3 days; P < 0.001). Pleural-fluid total protein and lactate dehydrogenase levels were higher, whereas glucose levels were lower, in the open thoracic surgery group (all P < 0.001). In the reported adjusted analyses, pleural-fluid total protein (adjusted OR 4.30 per 1 g/dL increase; 95% CI 1.90 - 9.60), glucose (aOR 0.32 per 10 mg/dL increase; 95% CI 0.19 - 0.54), ibuprofen exposure (aOR 3.39; 95% CI 1.09 - 10.52), and diclofenac exposure (aOR 4.41; 95% CI 1.12 - 17.33) were associated with open thoracic surgery. Conclusions: Pleural-fluid biochemical characteristics and preadmission nonsteroidal anti-inflammatory drug exposure were associated with open thoracic surgery in this retrospective cohort. These findings are exploratory, do not establish causation or clinical surgical thresholds, and should not be used as a stand-alone prediction rule.
Investigation of the Prevalence of <i>Yersinia enterocolitica</i> Contamination in Beef, Sheep, and Poultry Meat
(Brieflands, 2026-06-30)
Ciamak Ghazaei
;
Ciamak Ghazaei [0000-0001-7802-879X]
Background: Yersinia enterocolitica is a zoonotic pathogen that causes foodborne gastroenteritis and is commonly transmitted through contaminated meat. Its ability to survive at low temperatures and develop antibiotic resistance makes its presence in food products a significant public health risk. Its widespread occurrence necessitates stringent food safety measures and further investigation of contamination sources and antibiotic resistance patterns. Objectives: This study aimed to investigate Y. enterocolitica contamination in beef, sheep, and poultry meat, determine its biotypes and serotypes, and assess its antibiotic resistance patterns. Methods: A total of 350 meat samples, comprising 100 beef, 100 sheep meat, and 150 poultry samples, were collected and analyzed using microbiological, biochemical, and bioserotyping methods. Antibiotic susceptibility testing was conducted to assess resistance patterns. The study also explored the role of environmental factors in Y. enterocolitica contamination and assessed its survival under different storage conditions. Results: The overall contamination rate of Y. enterocolitica was 16.9%, with the highest prevalence in sheep meat (28%), followed by poultry (14%) and beef (10%). Bioserotyping identified three biotypes (1A, 1B, and 2), of which biotype 1A was the most prevalent (73.1%). The predominant serotype was O:5, with some isolates classified as O:3 or non-typeable. Antibiotic susceptibility testing revealed high resistance to ampicillin (84.6%) and cephalexin (76.9%), whereas 88.5% and 92.3% of isolates were susceptible to ciprofloxacin and colistin, respectively. Additional tests demonstrated increased bacterial survival at low temperatures and persistence in contaminated meat for extended periods, even under refrigeration. Conclusions: The substantial contamination of meat products, particularly sheep meat, with Y. enterocolitica highlights the potential risk of foodborne infections. Future research should focus on molecular characterization and intervention strategies to control Y. enterocolitica contamination in the food supply chain.
Repurposing the Antipsychotic Olanzapine as a Protective Agent in Colitis: Involvement of P65 NF-κB/TLR4 Pathway and Serotonin Signaling
(Brieflands, 2026-12-31)
Tayebeh Noori
;
Mohammadreza Esmailzadeh
;
Antoni Sureda
;
Mozafar Khazaei
;
Mohammad Hosein Farzaei
Background: Serotonin acts as an immune modulator, and altered serotonin signaling has been linked to intestinal inflammation. Olanzapine is an atypical antipsychotic with high affinity for serotonin 5-HT2A receptors, which it antagonizes. Objectives: This study investigated the effects of olanzapine on acetic acid-induced colitis in rats. Methods: Thirty-five rats were randomly assigned to seven groups (n = 5 per group): control, acetic acid, sulfasalazine (500 mg/kg), olanzapine (2.5 or 5 mg/kg), serotonin (1 mg/kg), and olanzapine (5 mg/kg) plus serotonin (1 mg/kg). After three days of pretreatment, colitis was induced in groups 2 - 7 by rectal administration of 1 mL of 4% acetic acid. Drug administration resumed two hours after induction and continued daily for five days. A 7-cm segment of distal colonic tissue was then collected for microscopic examination, hematoxylin and eosin (H&E) staining, and immunohistochemical assessment of nuclear factor κB (NF-κB) p65 and Toll-like receptor 4 (TLR4) protein expression. Results: Macroscopic examination revealed significant differences in inflammation and mucosal integrity between the acetic acid group and the sulfasalazine and olanzapine groups. Protein expression of NF-κB p65 and TLR4 was markedly lower in the olanzapine groups than in the acetic acid group and was significantly lower in the olanzapine plus serotonin group than in the serotonin group. Conclusions: Through its antagonistic effects on serotonin and its reduction of NF-κB/TLR4 pathway activity, olanzapine reduced inflammation and mucosal damage, as assessed macroscopically and histologically. Further investigations are needed to confirm and extend these findings.
Identification of Platelet-related Genes and Immune Cells in Hepatocellular Carcinoma
(Brieflands, 2026-12-31)
Hua Yu
;
Shuhuai Chen
;
Hua Yu [0009-0009-2289-1207]
Background: Platelet activity plays a crucial role in the development of hepatocellular carcinoma (HCC). Objectives: This study aimed to investigate the prognostic role of platelet-related genes (PRGs) in HCC. Methods: This retrospective bioinformatics study used publicly available transcriptomic and clinical datasets. Differential expression analysis, weighted gene coexpression network analysis, Cox regression, and least absolute shrinkage and selection operator regression were used to identify optimal differentially expressed platelet-related genes associated with HCC in the The Cancer Genome Atlas (TCGA) cohort, using a curated PRG set. A risk score model was then constructed, and a nomogram integrating the risk score and independent prognostic factors was developed. Finally, differences in immune cell infiltration between risk groups were examined, and PRG-related pharmaceutical agents were explored. Results: Six signature genes (ABCC4, CD109, IGF1, GNG4, SPP2, and GNA14) were identified and used to establish a risk-score model. The model distinguished high-risk from low-risk patients in the training set (area under the curve = 0.776) and the validation set (area under the curve = 0.764). The high-risk group had significantly poorer overall survival (hazard ratio [HR] = 2.271; 95% CI, 1.580 - 3.262; log-rank P = 5.18 × 10-6). Multivariable Cox regression identified age, pathologic stage, and risk score (HR = 1.849; 95% CI, 1.249 - 2.736; P = 2.13 × 10-3) as independent prognostic factors. The nomogram showed good predictive performance for 1-, 3-, and 5-year survival (concordance index = 0.731, 0.780, and 0.789, respectively). Immune analysis revealed significant differences in 9 immune cell types between the high-risk and low-risk groups, and drug network analysis identified associations with 25 small-molecule drugs. Conclusions: A PRG-based prognostic classifier was developed to estimate clinical outcomes in patients with HCC. Because no treatment-response analysis was performed, the value of this classifier in guiding individualized therapy remains to be established.