The company was first founded by Seyyed M. Miri and Seyed-M Alavian as an editorial group in a Medical Institute in 2007 to publish its medical journal. After three years of experience, the number of journals increased to 5 journals, and the company launched its first form of business as a VOF (collaboration) professional STM company in Heerlen, the Netherlands, which was called "Kowsarmedical Publishing." Respecting the publishing services (from submission to publishing), especially an in-house "Journal Management System," our journals increased to more than 60 STM journals between 2010 and 2019. Since 2022, "Brieflands" is the new brand name that acts as a "Science, Technical, Medical Publisher" that publishes more than 50 journals with the services provided by 97 expert employees in three different branches.

Business Profile

  • Brieflands is a Registered Trademark with record number 1454012.
  • Brieflands has been registered as a General partnership (Vennootschap onder firma) company in the Chamber of Commerce (Kamer van Koophandel) of the Netherlands since 2010.
  • Nedmedica is our related company which is specialized in Author Services. 
  • Our former branding name was Kowsarmedical Publishing (2010-2021).

Recent Submissions

A Prospective Study of Right Ventricular Function After Coronary Artery Bypass Grafting: Are Usual Echocardiographic Parameters Useful?
(Shiraz University of Medical Sciences, 2024-12-31) Firoozeh Abtahi; Zohreh Bazyar; Khalil Zarrabi; Mani Hassanzadeh; Zahra Mehdipour Namdar; Amir Aslani; Seyed Ali Hosseini; Armin Attar
Background: The best method for accurately assessing the right ventricle (RV) after coronary artery bypass grafting (CABG) remains controversial. In this study, we aimed to investigate several echocardiographic RV function indices to determine which are most effective in evaluating RV function post-CABG. Objectives: Here, we aimed to assess RV functional parameters after CABG using echocardiography. Methods: This prospective before-after study was conducted on 60 patients scheduled for CABG. The patients were assessed before and six weeks after CABG using standard echocardiography and Speckle-Tracking Echocardiography (STE). The significance of changes in study parameters was evaluated using the paired t-test or the non-parametric Wilcoxon test. Two-sided P-values ≤ 0.05 were considered statistically significant. Statistical analysis was performed using SPSS software, version 16.0. Results: Six weeks after CABG, we found significant changes in two parameters: Tricuspid annular plane systolic excursion (TAPSE) and S’ tissue Doppler imaging (20.82 ± 2.53 vs. 14.60 ± 1.84, P = 0.01; 11.79 ± 1.99 vs. 8.80 ± 0.88, P = 0.01, respectively). However, no significant changes occurred in the right ventricular global 2D longitudinal strain or free wall longitudinal strain (-18.83 ± 2.88 vs. -18.79 ± 2.66, P = 0.88; -21.29 ± 3.36 vs. -20.86 ± 3.17, P = 0.12, respectively). Conclusions: TAPSE and S’ tissue Doppler imaging indices change following CABG and cannot be considered standard echocardiographic parameters for assessing RV function after the procedure. However, the two major parameters for right ventricular functional assessment, global 2D longitudinal strain and free wall longitudinal strain, may be less affected by CABG and thus could be more reliable as standard parameters.
The Level of Satisfaction with Blended Learning via the Flipped Classroom Approach in the Epidemiology Course Among Nursing Students
(Brieflands, 2024-06-30) Zahra Farsi; Farzane Taghaee; Somayeh Azarmi; Abdolah Fathi Moghaddam
Background: The flipped classroom (FC) instructional strategy, as a blended learning approach, encourages students to take an active role in the learning process. Objectives: This study aimed to investigate the level of satisfaction with FC in the epidemiology course among nursing students. Methods: This descriptive-analytical study with a cross-sectional research design was conducted in 2022 at a school of nursing in Tehran, Iran. A total of 109 nursing students enrolled in the second semester of an undergraduate program were recruited via convenience sampling. These students were taught using the FC approach. The lecturer initially prepared teaching materials for each session in the form of multimedia files and uploaded them on the offline NAVID Virtual Education System. Subsequently, a series of questions related to the teaching materials were given to the students to answer in groups of 3 to 4 and discuss. The researcher facilitated the discussion to address any doubts among the students. After completing eight sessions, the Questionnaire for Satisfaction with Flipped Classroom (QSFC), with confirmed validity and reliability, was administered to evaluate the level of satisfaction among the students. Results: The majority of students expressed satisfaction with FC at moderate (48.6%) to high (47.7%) levels. Additionally, most male students (67.3%) reported being highly satisfied with FC, while 46% of female students showed a moderate level of satisfaction. The overall mean satisfaction score with FC was 55.36 ± 12.54, indicating a moderate level of satisfaction. This total score was not significantly correlated with students' age (P = 0.086), but the moderate level of satisfaction among male students was higher than that among females (P = 0.017). Conclusions: The study results suggest that FC, as a type of blended learning, is an appropriate teaching method in nursing education, as it enhances students' satisfaction levels. Improving the quality of virtual education infrastructure and facilities and enhancing teachers' capabilities in utilizing new teaching methods can enhance the quality of education, especially in critical situations.
The Protective Effects of Pistacia Atlantica Gum in a Rat Model of Aluminum Chloride-Induced Alzheimer’s Disease via Affecting BDNF and NF-kB
(Brieflands, 2024-12-31) Mohammad Mehdi Gravandi; Seyede Zahra Hosseini; Seyede Darya Alavi; Tayebeh Noori; Antoni Sureda; Roshanak Amirian; Mohammad Hosein Farzaei; Samira Shirooie
Alzheimer's disease (AD) is a neurodegenerative condition characterized by progressive cognitive deterioration, including deficits in memory and other cognitive functions. Oxidative stress and free radical damage play significant roles in its pathogenesis. This study aimed to investigate the potential anti-inflammatory and neuroprotective effects of Pistacia atlantica gum (administered at doses of 50 and 100 mg/kg for 14 days) in a rat model of AD induced by aluminum chloride (AlCl3). Behavioral changes were assessed using open field, passive avoidance, and elevated plus maze tests. Additionally, nitrite levels, nuclear factor-kappa B (NF-κB), brain-derived neurotrophic factor (BDNF), and immunostaining were evaluated. Administration of P. atlantica gum significantly increased step-through latency in the passive avoidance test (P < 0.01 and P < 0.001), enhanced mobility in the open field test (P < 0.01 and P < 0.001), and reduced anxiety-like behaviors in the elevated plus maze (P < 0.001) compared to the AlCl3 group. Treatment with the gum partially normalized the elevated levels of NF-κB and the decreased levels of BDNF caused by AlCl3 exposure. Our findings suggest that P. atlantica gum administration may alleviate oxidative stress, neuroinflammation, and cognitive impairment in AD rats.
Two-Year Follow-up Outcomes of Non-lesional Epilepsy Surgery in Iran
(Brieflands, 2024-07-31) Shakila Meshkat; Vajiheh Aghamollaii; Atefeh Behkar; Arshia Zardoui; Mojtaba Shahbazi; Abbas Tafakhori
Background: Despite treatment with anti-epileptic drugs, 30% of epileptic patients continue to experience seizures, making surgery a viable option. Surgery has shown efficacy even in non-lesional epileptic individuals, although there is limited research on this topic. Objectives: This study aimed to investigate surgical outcomes in individuals with drug-resistant epilepsy (DRE) who undergo surgery despite having non-lesional magnetic resonance imaging (MRI) findings. Methods: This observational longitudinal study was conducted between 2017 and 2020 at a referral hospital in Tehran, Iran. Using census sampling, we screened 750 epilepsy cases and enrolled 80 patients (42 women and 38 men) with DRE and non-lesional MRI findings who underwent epilepsy surgery. We collected patients' demographics and seizure characteristics. A 2-year follow-up was conducted to assess the seizure freedom rate. We compared seizure-free and non-seizure-free patients who underwent temporal epilepsy surgery, extratemporal epilepsy surgery, corpus callosotomy, and Vagus nerve stimulation (VNS) using chi-square, Fisher exact, and binary logistic regression tests. Results: The seizure freedom rate was 62.7% for temporal surgery, 83.33% for extratemporal surgery, 26.66% for corpus callosotomy, and none for patients who underwent VNS. There was no difference between seizure-free and non-seizure-free patients in terms of their baseline characteristics, seizure semiology, lesion features, and post-operative findings (P-values > 0.05), except that patients without a history of febrile convulsions tended to experience more seizure freedom after extratemporal surgery (P = 0.007). Additionally, older patients tended to experience more seizure freedom after temporal surgery (P = 0.03). Conclusions: This study underscores the potential benefits of epilepsy surgery in non-lesional DRE patients. Further research is needed to establish criteria for patient selection in this context.
In Vitro Scolicidal Effect of Urtica dioica and Pyrus boissieriana Extracts Against Protoscoleces of Echinococcus granulosus
(Brieflands, 2024-07-31) Kimia Goudarzi; Rasoul Alimi; Tandis Zarghami; Mohammad Saleh Bahreini; Mohamad Ghanimatdan; Meysam Sharifdini; Erfan Kohansal; Aref Teimouri
Background: Cystic echinococcosis (CE) is one of the most important neglected diseases and a public health concern worldwide. Due to the poor efficacy of current drugs, novel therapeutic approaches are urgently needed. Objectives: This study evaluated the scolicidal effects of the hydroalcoholic extract of Urtica dioica and the chloroformic extract of Pyrus boissieriana on protoscoleces of CE cysts. Methods: Protoscoleces were aseptically aspirated from the livers of sheep naturally infected with CE cysts. To assess the scolicidal effect of these herbal extracts, various concentrations of both extracts (5, 10, 20, 40, and 80 mg/mL) were added to a suspension of 3 × 103 washed protoscoleces. After 10, 20, 30, 60, and 120 minutes of exposure, eosin stain was added to each tube, and the viability of protoscoleces was evaluated by flame cell motility under a light microscope, as well as impermeability to 0.1% eosin solution. All experiments were performed in triplicate. Results: The scolicidal effects of U. dioica extracts at a concentration of 80 mg/mL were 81% and 89% after 60 and 120 minutes of exposure, respectively. Almost the same results were obtained for P. boissieriana extracts at a concentration of 80 mg/mL (81.33% and 89% after 60 and 120 minutes of exposure, respectively), which were significantly different from the negative control group (P < 0.001). However, the extract of U. dioica exhibited stronger scolicidal effects compared to the extract of P. boissieriana at concentrations lower than 40 mg/mL (P < 0.001). Conclusions: The present findings indicate that both U. dioica and P. boissieriana extracts possess high protoscolicidal activities and could be used as alternative natural medicines in the treatment of CE. However, further studies are required to verify these findings through assessment in animal models and clinical subjects.