Brieflands

History

The company was first founded by Seyyed M. Miri and Seyed-M Alavian as an editorial group in a Medical Institute in 2007 to publish its medical journal. After three years of experience, the number of journals increased to 5 journals, and the company launched its first form of business as a VOF (collaboration) professional STM company in Heerlen, the Netherlands, which was called "Kowsarmedical Publishing." Respecting the publishing services (from submission to publishing), especially an in-house "Journal Management System," our journals increased to more than 60 STM journals between 2010 and 2019. Since 2022, "Brieflands" is the new brand name that acts as a "Science, Technical, Medical Publisher" that publishes more than 50 journals with the services provided by 97 expert employees in three different branches.

Business Profile

Brieflands is a Registered Trademark with record number 1454012.
Brieflands has been registered as a General partnership (Vennootschap onder firma) company in the Chamber of Commerce (Kamer van Koophandel) of the Netherlands since 2010.
- KvK number: 89235444.
- BTW (VAT) number: NL864918896B01 (check online at VIES )
- RSIN: 864918896
Nedmedica is our related company which is specialized in Author Services.
Our former branding name was Kowsarmedical Publishing (2010-2021).

Communities in Brieflands

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Recent Submissions

Associations of Occupational Exposure to Respirable Crystalline Silica with Pulmonary Function and Liver-related Biochemical Markers Among Gol-e-Gohar Iron Ore Miners
(Brieflands, 2026-11-30)
Mahvash Safinejad
;
Hassan Irvani
;
Ali Meshkinian
;
Mansour R Azari
;
Athena Rafieepour
Background: Occupational exposure to airborne dust in iron ore mining is a well-established risk factor for pulmonary impairment. However, its potential systemic effects, particularly on hepatic function, have received considerably less attention. Objectives: This study evaluated the associations between occupational exposure to respirable dust and crystalline silica and pulmonary function and liver-related biochemical parameters among workers at the Gol-e-Gohar mining complex using personal exposure monitoring, spirometry, and plasma biochemical analyses. Methods: This cross-sectional study measured aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase (ALP), cholesterol, and triglycerides in blood samples from 211 individuals (71 controls and 140 exposed workers). Spirometry was used to assess forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), FEV1/FVC, forced expiratory flow at 25% - 75% of FVC (FEF25 - 75), and peak expiratory flow rate. Respirable dust and crystalline silica exposure were evaluated using National Institute for Occupational Safety and Health (NIOSH) Method 0600 and an optimized NIOSH Method 7602, respectively. Data were analyzed using SPSS V21 at the 95% confidence level. Results: Respirable dust exposure was not significantly correlated with pulmonary function indices (P > 0.05). However, respirable crystalline silica exposure was significantly negatively correlated with %FVC (r = −0.40, P = 0.01), %FEV1 (r = −0.45, P = 0.024), and %FEF25 - 75 (r = −0.46, P = 0.02). The mean ALP level was significantly higher in the exposure group than in the control group (P = 0.007). No statistically significant between-group differences were observed in the remaining liver-related biochemical markers. Triglyceride levels were negatively correlated with respirable dust exposure (r = -0.23, P = 0.01), whereas the other liver-related parameters showed no significant associations. Conclusions: Respirable crystalline silica exposure was associated with a spirometric pattern compatible with possible restrictive pulmonary impairment. Liver-related biochemical markers were largely unchanged, apart from an isolated elevation in ALP, which may indicate subclinical hepatic stress. Longitudinal studies incorporating multivariable adjustment and more advanced hepatic assessment are needed to clarify the systemic risks of mining-related pollutant exposure.
Molecular Mechanisms of Immune Dysregulation in Triple-Negative Breast Cancer
(Brieflands, 2026-09-30)
Fatemeh Kianivala
;
Negin Molazadeh
;
Omar Layth Qassid
;
Fatemeh Kianivala [0009-0008-1472-9421]
;
Negin Molazadeh [0000-0003-2857-0649]
Context: Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype characterized by the absence of expression of estrogen receptors, progesterone receptors, and human epidermal growth factor receptor 2. The behavior of TNBC is strongly influenced by inflammatory and immunosuppressive mechanisms. The tumor microenvironment contains diverse immune, stromal, and vascular components that regulate tumor progression, metastasis, therapeutic response, and immune escape. Evidence Acquisition: The literature was identified by searching PubMed, Scopus, Web of Science, and clinical trial registries using the following keywords: triple-negative breast cancer, inflammation, immune dysregulation, tumor microenvironment, cytokines, and tumor-infiltrating lymphocytes. Priority was given to clinical trials, translational studies, systematic reviews, and mechanistic investigations published during the last decade; landmark earlier studies were also considered. Results: Inflammatory signaling represents a fundamental biological continuum in TNBC, spanning immune-desert, immune-excluded, and immune-inflamed phenotypes. Persistent activation of central inflammatory nodes, predominantly NF-κB and the reciprocal IL-6/JAK/STAT3 signaling axis, orchestrates cancer stemness, epithelial-mesenchymal transition, and immunosuppressive stromal remodeling. Clinically, landmark trials such as KEYNOTE-355 have demonstrated the benefit of combining pembrolizumab with chemotherapy in PD-L1-positive advanced disease with a combined positive score ≥ 10. However, reliance on a single biomarker, such as PD-L1 or tumor-infiltrating lymphocytes, remains inadequate to capture functional immune dysregulation. Conclusions: Chronic inflammation driven by crosstalk between NF-κB and IL-6/JAK/STAT3 sustains immunosuppression and therapeutic refractoriness in TNBC. Overcoming resistance will require moving beyond static biomarkers toward combination strategies that integrate checkpoint inhibitors with targeted inhibitors of these central inflammatory pathways.
Association of Blood and Inflammatory Factors with Stroke Type and in-Hospital Outcome in Patients Presenting to the Emergency Department of Imam Khomeini Hospital, Urmia
(Brieflands, 2026-12-31)
Babak Choobi Anzali
;
Sarina Samaei
;
Maryam Rasouli
;
Maryam Rasouli [0000-0002-9365-0269]
Background: Stroke is a major cause of hospitalization in neurology wards and a leading cause of disability and mortality from neurological disorders. Hematologic and inflammatory markers may play a role in stroke occurrence and prognosis. Objectives: This study investigated the association of blood and inflammatory factors with stroke type and in-hospital outcome in patients presenting to the emergency department of Imam Khomeini Hospital, Urmia, in 2022. Methods: This retrospective analytical cross-sectional study used data extracted from the medical records of 721 patients with stroke. Data were analyzed using SPSS version 27 and appropriate statistical tests. Results: Of the 721 patients, 590 (81.8%) had ischemic stroke and 131 (18.2%) had hemorrhagic stroke. In the hemorrhagic stroke group, 55.7% were male and 44.3% were female; the proportions of male and female patients were equal in the ischemic stroke group. Mean age was 65.2 ± 16.1 years in the hemorrhagic stroke group and 71.1 ± 14.6 years in the ischemic stroke group. Mean hemoglobin and hematocrit levels in the hemorrhagic stroke group were 14.29 ± 2.18 g/dL and 42.51 ± 5.92%, respectively; both were significantly higher than the corresponding values of 13.71 ± 2.02 g/dL and 41.31 ± 5.64% in the ischemic stroke group. Mean C-reactive protein (CRP) levels were 34.34 ± 25.88 mg/L in the hemorrhagic stroke group and 34.50 ± 27.62 mg/L in the ischemic stroke group. Mean erythrocyte sedimentation rate (ESR) values were 22.084 ± 22.28 mm/h and 22.998 ± 27.79 mm/h, respectively. Neither CRP nor ESR differed significantly between the groups (P > 0.05). Mortality was significantly higher among patients with hemorrhagic stroke than among those with ischemic stroke (40.5% vs 18.6%; P = 0.001). Conclusions: Ischemic stroke was more common than hemorrhagic stroke, but hemorrhagic stroke was associated with higher in-hospital mortality. Although hemoglobin and hematocrit levels were higher in the hemorrhagic stroke group, CRP and ESR did not differ significantly between stroke types and were not significantly associated with in-hospital outcomes.
Mast Cells as Central Hubs of Immune Dysregulation: Decoding Novel Pathogenic Circuits and Pioneering Therapeutics in Autoimmunity
(Brieflands, 2026-09-30)
Bahareh Abd Nikfarjam
;
Kamyar Entezari
;
Shahrzad Ghorbanzadeh
;
Sepide Rasouli
;
Salar Dadras
Context: Mast cells are increasingly recognized as central orchestrators of immune dysregulation in autoimmune and inflammatory diseases, extending their established role as histaminergic effector cells in allergy. Evidence Acquisition: This review synthesizes recent evidence positioning mast cells as key regulators of chronic inflammation, tissue remodeling, and neuroinflammation. Studies published between 1997 and 2026 have identified mast cells as focal points of immune dysregulation and helped define novel pathogenic pathways and develop therapeutic approaches for various autoimmune conditions. Results: We describe the multifaceted roles of mast cells in breaching immune-privileged sites, amplifying autoantibody production through interactions with B and T cells, and promoting pathology in rheumatoid arthritis, lupus, and juvenile dermatomyositis through IgE-independent pathways involving receptors such as MRGPRX2. We also explore their contributions to neurodegenerative processes, including Alzheimer's disease, through disruption of the blood-brain barrier and facilitation of leukocyte infiltration. Beyond these mechanisms, we critically evaluate emerging therapeutic strategies designed to precisely modulate mast cell activity. These strategies include targeting FcεRI signaling with Bruton's tyrosine kinase inhibitors, engaging inhibitory checkpoints such as CD300a, and depleting mast cells through KIT receptor inhibition. Conclusions: By reframing mast cells as dynamic cellular rheostats and actionable therapeutic nodes, this review outlines approaches for translating these insights into targeted therapies for refractory autoimmune conditions.
Nanoencapsulation of Thyme Essential Oil by Electrospinning and Evaluation of Its Antimicrobial Properties Against Antibiotic-resistant <i>Salmonella typhimurium</i>
(Brieflands, 2026-10-31)
Gholamreza Haghighi
;
Hasan Ghorbani Ghozhdi
;
Laleh Shahraki Mojahed
;
Saeide Saeidi
;
Zahra Bigomi
Background: Controlling Salmonella in poultry is a public health priority. Essential oils have attracted interest as natural food preservatives because of their antioxidant and antimicrobial properties. Objectives: This study aimed to nanoencapsulate thyme essential oil using electrospinning and to characterize the resulting nanofibers and their antibacterial properties. Methods: Nanofibers containing different percentages of essential oil were prepared, and their physicochemical and antimicrobial properties were investigated. Results: Fourier transform infrared spectroscopy was used to evaluate molecular interactions in zein-acetic acid nanofibers containing thyme essential oil. The broad band at 3200 - 3400 cm-1, corresponding to O-H and N-H stretching vibrations, increased in intensity and broadened after the addition of essential oil, indicating the formation of hydrogen bonds between the phenolic compounds in the essential oil and zein. The characteristic amide I and amide II bands, at approximately 1650 cm-1 and 1540 cm-1, respectively, remained largely unchanged, indicating that the zein protein structure remained stable during electrospinning. Increased band intensity in the 1000 - 1250 cm-1 region, corresponding to C-O vibrations, confirmed the presence of essential oil in the fiber matrix. Conclusions: The fibrous nanoparticles exhibited good antimicrobial properties and could be used as food coatings.