Brieflands

History

The company was first founded by Seyyed M. Miri and Seyed-M Alavian as an editorial group in a Medical Institute in 2007 to publish its medical journal. After three years of experience, the number of journals increased to 5 journals, and the company launched its first form of business as a VOF (collaboration) professional STM company in Heerlen, the Netherlands, which was called "Kowsarmedical Publishing." Respecting the publishing services (from submission to publishing), especially an in-house "Journal Management System," our journals increased to more than 60 STM journals between 2010 and 2019. Since 2022, "Brieflands" is the new brand name that acts as a "Science, Technical, Medical Publisher" that publishes more than 50 journals with the services provided by 97 expert employees in three different branches.

Business Profile

  • Brieflands is a Registered Trademark with record number 1454012.
  • Brieflands has been registered as a General partnership (Vennootschap onder firma) company in the Chamber of Commerce (Kamer van Koophandel) of the Netherlands since 2010.
  • Nedmedica is our related company which is specialized in Author Services. 
  • Our former branding name was Kowsarmedical Publishing (2010-2021).
 

Communities in Brieflands

Select a community to browse its collections.

Recent Submissions

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Treatment of Renal Failure Due to Multiple Myeloma by Plasmapheresis Adjunctive to Chemotherapy: A Systematic Review
(Brieflands, 2026-02-28) Firouzeh Moeinzadeh; Mojgan Mortazavi; Raheleh Hamedanian; Raheleh Hamedanian [0009-0002-3090-1750]
Context: Up to half of multiple myeloma (MM) patients develop renal impairment from elevated free light chains (FLCs). Plasmapheresis can rapidly reduce FLCs, but its clinical benefit remains unclear. This systematic review therefore evaluated the efficacy of plasmapheresis as an adjunct to chemotherapy in treating multiple myeloma-related renal failure (MM-RF). Evidence Acquisition: A comprehensive literature search was performed covering PubMed, Web of Science, Cochrane Library, Embase, and Google Scholar databases from inception to October 2025. All steps were performed by two independent reviewers and any discrepancies between reviewers were resolved through discussion or adjudication by a third reviewer. Results: Eight studies were included, three randomized clinical trials (RCTs) (n = 147) and five observational studies (n = 157). Evidence for survival benefit was inconsistent. One small RCT reported a significant improvement in survival in the plasmapheresis group (66% vs 28%) over the reported study follow-up period, whereas the largest RCT and all observational studies with variable follow-up durations found no difference in survival between plasmapheresis plus chemotherapy and chemotherapy alone. Two RCTs showed greater reductions in serum creatinine and dialysis dependence with plasmapheresis, but these findings were not replicated in the largest RCT or in the observational studies, which showed no clear renal benefit. Conclusions: In conclusion, although plasmapheresis may offer some renal recovery benefits in select patients, the current evidence does not demonstrate a meaningful improvement in either renal outcomes or survival in MM-RF. More well-designed, large-scale randomized trials and observational prospective studies are needed to evaluate plasmapheresis in combination with modern anti-myeloma therapies.
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Preparation and Physicochemical Characterization of Ofloxacin-Loaded Alginate-Chitosan Nanogel: Comparison to Ofloxacin-Loaded Alginate Nanogel
(Brieflands, 2026-02-28) Masoume Mohammadi GhanatGhestani; Bahareh Sabeti; Saeed Manoochehri; Saeed Manoochehri [0000-0002-3748-9431]
Background: Alginate is a versatile polymer that has been used in various industries, including food and pharmaceuticals. We showed that chitosan, a positively charged polymer, enhances the physicochemical properties of drug carriers in drug delivery. Objectives: The aim of this study is to investigate the potential of an alginate-chitosan nanogel (Alg-Chi NG) drug delivery system in comparison to an alginate nanogel. Our specific goal is to compare the properties of an alginate nanogel (Alg-NG) containing ofloxacin with an Alg-Chi NG loaded with ofloxacin, to determine the potential benefits of incorporating chitosan in the nanogel formulation. Methods: The Alg-NG containing ofloxacin was prepared using the emulsification/internal gelation method. The Alg-NG was formed through a chelation reaction between alginate and calcium to make a nanogel. Additionally, ionic interactions between the amine group of chitosan and the carboxylic group of alginate led to the formation of a polyelectrolyte complex known as Alg-Chi NG. Results: The size of Alg-NG and Alg-Chi NG was around 70 ± 4.7 nm and around 150 ± 6.2 nm, respectively. We showed that the Fourier transform infrared spectroscopy of Alg-Chi NG had a new peak at 1736 cm⁻¹ that confirmed a polyelectrolyte complex between alginate and chitosan. The release of ofloxacin from Alg-NG and Alg-Chi NG after 6 hours was 54.5 ± 2.56% and 34.8 ± 2.51%, respectively. These results suggest that using chitosan could reduce the drug release rate. The kinetic model for both formulations was more closely fitted with the Higuchi model, in which Alg-Chi NG was closer to 1. Conclusions: According to the results, alginate-chitosan nanogel could be a practical approach for the drug delivery of hydrophilic drugs.
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Genetic and Molecular Profiling of PLIN5 and LCN2 in Hepatocellular Carcinoma: Implications for Diagnosis and Prognosis
(Brieflands, 2025-07-31) Mahsa Sadat Reypour; Bita Moudi; Massoud Houshmand; Seyyedeh Behnaz Motahari; Bita Moudi [0000-0001-6893-625X]
Background: Hepatocellular carcinoma (HCC) is a major global health challenge, often diagnosed at advanced stages, necessitating reliable biomarkers for early detection and prognosis. Objectives: This study investigates the mRNA expression levels and polymorphisms of perilipin 5 (PLIN5) and lipocalin 2 (LCN2) in liver tissues of HCC patients compared to healthy controls, alongside histopathological analyses. Methods: In a case-control study involving 50 HCC patients and 50 healthy liver donors, we quantified PLIN5 and LCN2 mRNA expression using Real-Time PCR, genotyped PLIN5 (rs1062223 G>A) and LCN2 (rs11556770 G>T) polymorphisms, and assessed stereological parameters including hepatocyte count, hepatocyte volume, Kupffer cell count, and fibrotic tissue volume. Results: Results showed significantly elevated PLIN5 and LCN2 mRNA expression in HCC tissues (P < 0.05). The PLIN5 rs1062223 A allele was significantly more frequent in HCC patients (P = 0.031), suggesting its role as a risk factor, while LCN2 rs11556770 showed no significant genotypic differences. Histopathologically, HCC tissues exhibited reduced hepatocyte and Kupffer cell counts, increased hepatocyte volume, and higher fibrotic tissue volume (P < 0.05). Conclusions: These findings highlight the pleiotropic roles of PLIN5 and LCN2 in HCC pathogenesis, suggesting their potential as candidate biomarkers, pending further validation.
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Studying the Preparedness of Selected Hospitals in Tehran in the Face of Natural Disasters and Accidents
(Brieflands, 2026-03-31) Mohammad Belal; Esmail Heidaranlu; Ali Nasiri; Mohammad Mohammadian; Alireza Basiri; Mohsen Abbasi Farajzadeh; Mohammad Belal [0000-0002-7808-8757]; Esmail Heidaranlu [0000-0003-4420-8754]; Ali Nasiri [0000-0003-4974-2964]; Mohammad Mohammadian [0000-0003-4974-2964]; Alireza Basiri [0009-0009-4515-5202]; Mohsen Abbasi Farajzadeh [0000-0002-2058-597X]
Background: Iran is one of the most disaster-prone countries in the world, with disasters caused by various natural and man-made hazards. Objectives: Given that hospitals play an important role in treating disaster victims, this study aimed to investigate the level of preparedness of selected military hospitals in Tehran in crisis situations. Methods: This study is cross-sectional, and the research population included selected military hospitals using the standard tool for hospital preparedness in the face of natural disasters across 17 dimensions. Results: Of the total 17 dimensions examined in selected military hospitals, the level of preparedness of Hospital A was assessed at a "good" level with 68.55% preparedness, hospital B at a "medium" level with 55.55%, and hospitals C and D with poor preparedness of 39.88% and 37.77%, respectively. The highest preparedness was observed in the areas of safety, capacity building, and cultural considerations, while the lowest was in the areas of triage and post-disaster recovery. Conclusions: Comprehensive planning and strengthening of weaknesses in disaster management and recovery are essential for hospitals. This includes the phases of anticipation, relief, and reconstruction. Hospitals should focus on strengthening triage and disaster recovery programs and training staff.
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Clinical Characteristics and Diagnostic Approaches in Paediatric Pneumocystis jirovecii Pneumonia: A Focus on Gastric Aspirate Samples
(Brieflands, 2026-07-31) Peter Kunc; Klaudia Gallikova; Jaroslav Fabry; Peter Ferenc; Katarina Istvankova; Zuzana Hrabovska; Kristina Handzusova; Matus Dohal; Renata Pecova; Peter Kunc [0000-0001-6770-5599]; Renata Pecova [0000-0003-4257-3213]
Background: Pneumocystis pneumonia (PCP) typically affects immunocompromised children, including those with HIV infection, those receiving cancer treatment, and those who have undergone transplantation. However, it also affects children from socioeconomically disadvantaged backgrounds. Objectives: This retrospective single center study aimed to describe the clinical characteristics of a cohort of paediatric patients with suspected PCP and to evaluate the clinical feasibility and diagnostic contribution of different sample types. Methods: Eligibility criteria included all paediatric patients presenting with clinical signs of pneumonia who underwent diagnostic testing for P. jirovecii based on clinical suspicion. Participant selection was based on a review of electronic and written medical records. This study specifically focused on the use of gastric aspirates, which were the most frequently collected samples in this population. A total of 277 patients between November 2017 and September 2024 underwent diagnostic tests, including real-time PCR analysis of laryngeal swabs, sputum, bronchoalveolar lavage, gastric aspirates, and pleural effusion. The study utilized descriptive statistics (frequencies, percentages, median, range) to summarize data; formal analytical statistical tests were not performed given the study's descriptive nature. Data on clinical outcomes were collected from medical records documenting patient follow-up post-treatment. Results: The diagnosis of PCP was confirmed in 36 patients (13%), ranging from 2 months to 2.5 years old, with 31 cases (86%) occurring in infants under 12 months. In our cohort, the diagnosis was most frequently established from gastric aspirates, which accounted for 29 of the 36 positive cases (80%), followed by bronchoalveolar lavage (8%), laryngeal swabs (6%), and sputum (6%). The predominant clinical presentation was prolonged respiratory deterioration with chronic cough and persistent refractory bronchoconstriction in 29 patients (81%). Fourteen patients (39%) experienced acute respiratory distress syndrome (RDS) and required additional oxygen and systemic corticosteroid therapy. Following appropriate treatment, clinical improvement, resolution of bronchial obstruction, and nutritional recovery were achieved. In the cohort of RT-PCR-positive cases, characteristics such as low socioeconomic status, malnutrition, poor sanitation, and exposure to tobacco smoke and combustion fumes were frequently observed, all of which are potential confounders or effect modifiers that may contribute to secondary immunodeficiency. Conclusions: The study's retrospective, single-centre design is subject to inherent limitations, such as potential selection bias. Although bronchoalveolar lavage is the ideal diagnostic method, its acquisition can be challenging in critically ill young infants. Our findings highlight the clinical utility of gastric aspirates as a valuable, minimally invasive alternative for diagnosing PCP in this vulnerable population.