Brieflands

History

The company was first founded by Seyyed M. Miri and Seyed-M Alavian as an editorial group in a Medical Institute in 2007 to publish its medical journal. After three years of experience, the number of journals increased to 5 journals, and the company launched its first form of business as a VOF (collaboration) professional STM company in Heerlen, the Netherlands, which was called "Kowsarmedical Publishing." Respecting the publishing services (from submission to publishing), especially an in-house "Journal Management System," our journals increased to more than 60 STM journals between 2010 and 2019. Since 2022, "Brieflands" is the new brand name that acts as a "Science, Technical, Medical Publisher" that publishes more than 50 journals with the services provided by 97 expert employees in three different branches.

Business Profile

  • Brieflands is a Registered Trademark with record number 1454012.
  • Brieflands has been registered as a General partnership (Vennootschap onder firma) company in the Chamber of Commerce (Kamer van Koophandel) of the Netherlands since 2010.
  • Nedmedica is our related company which is specialized in Author Services. 
  • Our former branding name was Kowsarmedical Publishing (2010-2021).
 

Communities in Brieflands

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Recent Submissions

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Role of Immune-Endothelial Cell Crosstalk in the Pathogenesis of Multiple Organ Dysfunction Syndrome (MODS): From Molecular Mechanisms to Therapeutic Targets
(Brieflands, 2026-06-30) Seyed Hossein Ardehali; Seyed Hossein Ardehali [0000-0001-6656-3875]
This article does not have an abstract.
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MDA Response to Ergocycle HIIT and Post-exercise Curcumin Supplementation in Badminton Athletes: A Quasi-Experimental Approach
(Brieflands, 2026-03-31) Gosy Endra Vigriawan; Lilik Herawati; Moch Yunus; Fajar Syamsudin; Lalu Moh Yudha Isnaini; Haydar Rafsya Farzana; Norhazira Abdul Rahim
Background: Badminton involves repeated high-intensity efforts that may increase reactive oxygen species production and lipid peroxidation during recovery. Malondialdehyde (MDA) is commonly used as a marker of lipid peroxidation. Curcumin has been investigated as a nutritional intervention for exercise-induced oxidative stress; however, evidence in badminton athletes after acute high-intensity interval training (HIIT) remains limited. Objectives: This study aimed to compare changes in plasma MDA levels between the curcumin and placebo groups during the 24-hour recovery period following acute ergocycle HIIT in male badminton athletes. Methods: This quasi-experimental pretest–posttest control-group study was conducted at the Physiology Laboratory, Universitas Brawijaya, from August to September 2025. Thirteen male badminton athletes or students aged 18 - 25 years with a normal Body Mass Index completed the protocol and were allocated to the curcumin group (500 mg without piperine; n = 6) or the placebo group (n = 7). After a 12-hour fast, participants completed a single 20-minute ergocycle HIIT session at approximately 90% of maximal heart rate, consisting of repeated 10-second bouts at 100 rpm followed by 50 seconds of active recovery at 45 - 55 rpm. The first blood sample (T1) was collected immediately after HIIT and before capsule ingestion. The second sample (T2) was collected 24 hours after supplementation, following an approximately 10-hour fast. Plasma MDA was measured using a commercial assay kit. Between-group differences at T2 were analyzed using an analysis of covariance adjusted for T1 MDA. Results: Plasma MDA increased from T1 to T2 in both groups. In the curcumin group, MDA increased from 0.65 ± 0.13 to 1.16 ± 0.44 nmol/mL, whereas in the placebo group, it increased from 1.03 ± 0.58 to 1.37 ± 0.47 nmol/mL. No significant between-group difference in the change was observed, and the Time × Group interaction was not significant (P = 0.163). In an additional baseline-adjusted analysis, the Group × T1 MDA term was significant (P = 0.001), indicating that the baseline-to-follow-up relationship differed between groups and that standard analysis of covariance without an interaction term was inappropriate for primary inference. Conclusions: In this preliminary sample, a single 500 mg dose of curcumin did not produce a consistent between-group effect on the 24-hour plasma MDA response. The baseline-adjusted sensitivity analysis suggested that the association between baseline and follow-up MDA differed by group, indicating substantial uncertainty in baseline-adjusted between-group comparisons. Further studies with larger samples, repeated dosing, a pre-exercise baseline assessment, and additional recovery time points are warranted.
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Panitumumab-Induced Severe Hypomagnesemia and Risk of Atrial Fibrillation and QT Prolongation: An Electrophysiologic Perspective
(Brieflands, 2026-12-31) Azin Alizadehasl; Haniyeh Faraji Azad; Sara Adimi; Amirhossein Shirinezhad; Azin Alizadehasl [0000-0002-8550-1378]; Sara Adimi [0000-0002-1060-6036]; Amirhossein Shirinezhad [0009-0003-7718-1938]
Introduction: Panitumumab-induced hypomagnesemia disrupts calcium and potassium channel function, prolongs the corrected QT (QTc) interval, and may create a substrate for atrial arrhythmogenesis. We describe a patient with metastatic colon cancer who developed severe hypomagnesemia and marked QTc prolongation during panitumumab therapy; however, atrial fibrillation did not occur. This case demonstrates rapid electrophysiological recovery after magnesium repletion and underscores the importance of cardiac monitoring in patients receiving epidermal growth factor receptor inhibitors. Case Presentation: A 68-year-old man with metastatic colon cancer receiving folinic acid, fluorouracil, and irinotecan plus panitumumab developed progressive hypomagnesemia, with the serum magnesium level decreasing from 0.78 mmol/L at baseline to 0.33 mmol/L by cycle 8, accompanied by hypokalemia. He remained asymptomatic. Before cycle 9, electrocardiography showed normal sinus rhythm without atrial fibrillation; however, the QTc interval had increased by 50 ms from baseline, from 410 to 460 ms. Panitumumab was withheld, and magnesium and potassium were repleted. Follow-up electrocardiography showed normalization of the QTc interval to 415 ms without atrial or ventricular arrhythmia. Conclusions: Panitumumab can cause clinically silent yet progressive hypomagnesemia, which may disrupt cardiac conduction and increase the risk of arrhythmias. Timely electrolyte repletion may reverse QTc prolongation, prevent arrhythmias, and allow continuation of anticancer therapy. Vigilant monitoring and prompt intervention are essential.
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Factors Associated with Upgrading of Pathological ISUP Grading Following Radical Prostatectomy: A Retrospective Cohort Study
(Brieflands, 2026-05-31) Reza Shahrokhi-Damavand; Emad Moaied Abedi; Samaneh Esmaeili; Ardalan Akhavan Tavakoli; Shahab Aali; Ehsan Kazemnezhad Leili; Samaneh Esmaeili [0000-0003-3826-758X]; Ardalan Akhavan Tavakoli [0000-0002-6385-4332]; Shahab Aali [0009-0004-1717-2690]; Ehsan Kazemnezhad Leili [0000-0002-9195-9094]
Background: Previous studies have reported discordance in Gleason scores (GSs) between needle biopsy results and radical prostatectomy (RP) specimens. Objectives: To identify factors associated with International Society for Urological Pathology (ISUP) grade upgrading in patients who underwent radical prostatectomy (RP). Methods: In this retrospective cohort study, 110 patients with prostate cancer who underwent RP between 2019 and 2024 were evaluated. Demographic data, laboratory results, pathological characteristics, and MRI findings (Prostate Imaging-Reporting and Data System [PI-RADS], intraprostatic cancerous lesions, extracapsular extension, and seminal vesicle invasion) were extracted from patient records. Patients were classified into two groups according to the presence or absence of ISUP grade upgrading. Upgrading was defined as any increase in ISUP grade in the RP specimen compared with that in the needle biopsy. Univariate and multivariate logistic regression analyses were performed to evaluate predictive factors for upgrading. Results: Among the 110 patients (mean age, 62.97 years), 47 (42.7%) had ISUP upgrading on RP compared with biopsy. In univariable analysis, age, PSA, PSA density (PSAD), the time interval between biopsy and RP, and MRI parameters were not significantly associated with ISUP upgrading (P > 0.05). In multivariate logistic regression analysis, both a free/total PSA (f/tPSA) ratio ≤ 10% (OR = 0.27, 95% CI, 0.11 - 0.65, P = 0.004) and an ISUP grade of 1 on biopsy (OR = 0.25, 95% CI, 0.11 - 0.57, P = 0.001) were independently associated with the risk of upgrading. Conclusions: An f/tPSA ratio of ≤ 10% and an ISUP grade of 1 on biopsy were associated with pathological upgrading. Prospective studies are required to validate these findings.
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A Dedicated Pediatric Intravenous Therapy Team: Five-Year Outcomes of a Nurse-Led Management Model
(Brieflands, 2026-07-28) Jin Ting; Xu Hong Zhen; Hongqin Zhou
Background: A dedicated pediatric intravenous therapy team may improve the quality, safety, and efficiency of vascular access care by centralizing specialized nursing expertise, standardizing technical procedures, and enhancing complication management. Objectives: This study aimed to describe the establishment and management of a dedicated pediatric intravenous therapy team at a single children's hospital and to report observed changes in service quality and efficiency over a 5-year period using a retrospective before-and-after observational design. Methods: The team was established in 2019. Management strategies included role definition, eligibility criteria, workflow standardization, and performance-based incentives. Indicators of service volume, puncture success rate, complication rate, and regional influence were compared descriptively between the preimplementation and postimplementation periods from 2019 to 2024. Results: After the team was established, the compound annual growth rate of outpatient maintenance procedures reached 44.5%, and the success rate of ultrasound-guided puncture exceeded 98%. The catheter-related infection rate declined to < 1‰. The mean satisfaction rate among pediatric patients and their parents was 99.3%. Although the total number of complications during in-hospital consultations decreased, exudation/bleeding at the PICC puncture site emerged as a new management priority, accounting for 35.3% of complications in 2024. Out-of-hospital consultations rebounded by 80.0% in 2024, and the team provided systematic training to 18 visiting nurses. Conclusions: In this single-center before-and-after observational study, the implementation of a dedicated pediatric intravenous therapy team was associated with improvements in observed nursing quality and efficiency. This model provides a practice-based reference for specialized pediatric nursing management; however, its causal effectiveness requires validation through more rigorous study designs.