The company was first founded by Seyyed M. Miri and Seyed-M Alavian as an editorial group in a Medical Institute in 2007 to publish its medical journal. After three years of experience, the number of journals increased to 5 journals, and the company launched its first form of business as a VOF (collaboration) professional STM company in Heerlen, the Netherlands, which was called "Kowsarmedical Publishing." Respecting the publishing services (from submission to publishing), especially an in-house "Journal Management System," our journals increased to more than 60 STM journals between 2010 and 2019. Since 2022, "Brieflands" is the new brand name that acts as a "Science, Technical, Medical Publisher" that publishes more than 50 journals with the services provided by 97 expert employees in three different branches.

Business Profile

  • Brieflands is a Registered Trademark with record number 1454012.
  • Brieflands has been registered as a General partnership (Vennootschap onder firma) company in the Chamber of Commerce (Kamer van Koophandel) of the Netherlands since 2010.
  • Nedmedica is our related company which is specialized in Author Services. 
  • Our former branding name was Kowsarmedical Publishing (2010-2021).

Recent Submissions

Comparison of Ropivacaine versus Bupivacaine in Spinal-Induced Hypotension in Preeclampsia Patients: A Randomized Control Trial
(Brieflands, 2024-02-29) Morteza Hashemian; Mohsen Barouni; Zahra Honarvar; Katayoun Alidousti; Seyed Amirabbas Mohajerani; Leila Rezaeizadeh
Background: Spinal anesthesia is considered to be the safest method of anesthesia for cesarean sections in patients with preeclampsia. Patients with preeclampsia are at an increased risk of experiencing severe hypotension following spinal anesthesia, which could have more profound and deleterious effects on both the fetus and the mother. However, bupivacaine, the most commonly used drug, can induce severe hypotension even at low doses. The purpose of this study is to minimize post-spinal hypotension in both the mother and the fetus. Objectives: To determine and compare the reduction in hypotension following spinal anesthesia in patients with preeclampsia between the ropivacaine and bupivacaine groups. Methods: In a randomized clinical trial, a total of 90 parturients with preeclampsia undergoing spinal anesthesia were enrolled and randomly divided into 2 groups: One receiving ropivacaine and the other receiving bupivacaine. The dose of spinal ropivacaine was 15 mg of a 0.5% solution, and the dose of bupivacaine was also 15 mg of a 0.5 % solution. Hemodynamic parameters, including systolic and diastolic blood pressure and heart rate, were recorded following the administration of spinal anesthesia. Pain scores and the time until the return of motor movement were also documented. Results: For statistical analysis, the t-test, Chi-square, and ANOVA tests were utilized to compare the groups. Demographic variables, including maternal age, gestational age, parity, and gravidity, were not significantly different between the 2 groups. The trend of mean systolic blood pressure (SBP) was significantly lower in the bupivacaine group compared to the ropivacaine group at all measured time points in the study (P < 0.05). The amount of ephedrine used after spinal anesthesia was significantly different at 2 and 4 minutes in the ropivacaine group compared to the bupivacaine group (P = 0.012, P = 0.025). Post-operative pain scores at 1 hour in recovery were not significantly different between the ropivacaine and bupivacaine groups (P = 0.015). The time to knee movement was also significantly shorter in the ropivacaine group compared to the bupivacaine group (P < 0.001). Conclusions: Ropivacaine reduces the incidence of hypotension in spinal anesthesia compared to bupivacaine for cesarean section in patients with preeclampsia. This is attributed to a lower occurrence of spinal-induced hypotension, improved hemodynamic control, reduced ephedrine usage, and faster patient ambulation. A future study could focus on investigating different dosages of both drugs with a larger number of participants.
The Effects of Resilience Training on Mental Health Among Students
(Brieflands, 2024-02-29) Mohammadreza Raeisoon; Yahya Mohammadi; Mohadese Talaie
Background: Research indicates that certain demographic groups, including girls, often experience lower-than-average levels of mental well-being. Therefore, it appears that one approach to enhancing mental health is by teaching resilience skills. Objectives: This study aimed to investigate the effects of resilience training on the mental health dimensions of sixth-grade female students in Qaynat city during the academic year 2021 - 2022. Methods: The study employed an experimental design with a control group, conducting pre- and post-tests. The statistical population comprised female sixth-grade students from an elementary school in Qaynat City. Thirty female students exhibiting high scores on measures of depression, anxiety, and stress were selected and randomly divided into two experimental groups, with 15 participants in each group. The experimental group underwent resilience training consisting of 8 sessions. The desired variables were measured using Lovibond and Lovibond's Depression, Anxiety, and Stress Scale (DASS). The data were analyzed using SPSS 25 software through independent samples t-tests and paired t-tests. Results: The findings revealed that the resilience training intervention significantly reduced symptoms of depression (F = 11.542), anxiety (F = 13.67), and stress (F = 6.01) in the experimental group (P = 0.001). Conclusions: The results suggest that participation in a resilience training program can improve students' mental health. Therefore, implementing such intervention programs in the form of workshops and establishing counseling and support groups may be beneficial for enhancing students' mental well-being.
Cardioprotective Effect of Hydroalcoholic Extract of Lepidium Draba on Isoproterenol-Induced Acute Myocardial Infarction in Rats.
(Brieflands, 2023-06-30) Maryam Kahyaei-Aaghdam; Vahid Shafiei-Irannejad; Sanaz Hamedeyazdan; Hamid Soraya
Background: Recently, there has been increased interest in medicinal plants for the discovery of new compounds to treat various disorders. A few studies have highlighted the antioxidant and anti-inflammatory effects of Lepidium draba (L. draba). Objectives: This study explores the potential cardioprotective effects of L. draba against myocardial infarction (MI) induced by isoproterenol. Methods: Isoproterenol (ISO) (100 mg/kg, injected subcutaneously for two consecutive days) was utilized to induce acute myocardial infarction in rats. The treated groups were administered hydroalcoholic extracts of L. draba intraperitoneally (ip) at doses of 50, 250, and 500 mg/kg for 2 consecutive days. Subsequently, the Electrocardiogram pattern, cardiodynamic parameters, cardiac remodeling, and lactate dehydrogenase levels were assessed. Results: The findings revealed that isoproterenol administration elevated the ST-segment and diminished the R-amplitude on the electrocardiogram, whereas treatment with L. draba extracts significantly ameliorated the ECG pattern. Isoproterenol injections lowered the mean arterial pressure (MAP), which was significantly increased by L. draba extract at all doses (P < 0.05). Furthermore, isoproterenol injections elevated lactate dehydrogenase (LDH) levels (P < 0.05) and cardiac fibrosis (P < 0.001), and treatment with the hydroalcoholic extract of L. draba significantly reduced both indices (P < 0.001 and P < 0.05, respectively). Conclusions: This study is the first to demonstrate that L. draba administration protects myocardial tissue from isoproterenol-induced infarction. Consequently, this plant could be recommended as an adjunct treatment for patients with acute MI.
The Influence of Foxp3 Treg Cell Gene Polymorphism (rs3761548) on FoxP3 Gene Expression in Patients with Chronic Hepatitis B Virus Infection
(Brieflands, 2024-12-31) Elnaz Rahimzadegan; Ameneh Elikaei; Zohreh Sharifi; Fatemeh Yari
Immune responses are pivotal in hepatitis B virus (HBV) infection, where Regulatory T cells (Treg) can contribute to sustaining the infection by suppressing immune responses. Forkhead box P3 (FoxP3) is the central regulator of Treg cells. In this case-control study, we investigated the role of FoxP3 -3279 (rs3761548) C/A polymorphism in the context of HBV infection. The study encompassed 140 healthy individuals as the control group and 70 individuals with chronic hepatitis B virus (CHBV) as the case group. The rs3761548 polymorphism was analyzed using the restriction fragment length polymorphism-PCR (PCR-RFLP) method. Furthermore, we evaluated FoxP3 gene expression in both HBV-positive and control groups using Real-Time PCR. The results revealed that the frequency of the AA genotype in the case and control groups was 52.9% and 44.3%, respectively, yielding an odds ratio (OR) of 1.411 with a 95% confidence interval (CI) ranging from 0.793 to 2.509. However, this difference did not achieve statistical significance (P = 0.242). Notably, the AC genotype was significantly more prevalent in the control group compared to the case group (P = 0.000). Moreover, FoxP3 gene expression was significantly higher in CHBV infection cases compared to the control group (P = 0.000). These findings suggest that the observed polymorphism may play a role in the pathogenesis and persistence of HBV infection. Nevertheless, further research is warranted to comprehensively investigate this phenomenon.
Protective Effect of Citicoline on Sodium Arsenite-Induced Nephrotoxicity in Mice
(Brieflands, 2024-02-28) Mohammad Javad Khodayar; Maryam Shirani; Mehrad Nikravesh; Elaheh Mohammadi; Laya Sadat Khorsandi; Saeedeh Shariati
Background: Sodium arsenite (NaAsO2) is a common mineral contaminant in drinking water in numerous parts of the world. It has been shown to have cardiovascular, metabolic, neuroendocrine, and urinary effects on the body. There is abundant scientific evidence that establishes a strong correlation between arsenic exposure and kidney-related disorders. Objectives: The present study aimed to investigate the potential protective effect of citicoline against NaAsO2-induced nephrotoxicity. Methods: The groups included a control group, a group treated with NaAsO2 at a concentration of 50 ppm, a group treated with Cit at a dosage of 1000 mg/kg, and three groups of NaAsO2 (50 ppm) co-treated with Cit at doses of 250, 500, and 1000 mg/kg, respectively. Results: Citicoline decreased the activity level of blood urea nitrogen (P < 0.001), creatinine levels (P < 0.001), thiobarbituric acid reactive substances (P < 0.001), nitric oxide (P < 0.001), inflammatory factors such as tumor necrosis factor-α (P < 0.001) and interleukin-6 (P < 0.001 and P < 0.001). Furthermore, Cit increased total thiol (P < 0.001) and activity levels of catalase (P < 0.05 and P < 0.001), superoxide dismutase (P < 0.01 and P < 0.001), and glutathione peroxidase (P < 0.001). Therefore, Cit reduced the harmful effects caused by the imbalance in oxidative and antioxidant systems and histopathological damage in NaAsO2-intoxicated mice, improving the damage caused by oxidative stress and inflammation. Conclusions: Our research indicates that Cit can shield the kidneys from the damaging effects of NaAsO2 by leveraging its antioxidant and anti-inflammatory properties.