Brieflands
History
The company was first founded by Seyyed M. Miri and Seyed-M Alavian as an editorial group in a Medical Institute in 2007 to publish its medical journal. After three years of experience, the number of journals increased to 5 journals, and the company launched its first form of business as a VOF (collaboration) professional STM company in Heerlen, the Netherlands, which was called "Kowsarmedical Publishing." Respecting the publishing services (from submission to publishing), especially an in-house "Journal Management System," our journals increased to more than 60 STM journals between 2010 and 2019. Since 2022, "Brieflands" is the new brand name that acts as a "Science, Technical, Medical Publisher" that publishes more than 50 journals with the services provided by 97 expert employees in three different branches.
Business Profile
- Brieflands is a Registered Trademark with record number 1454012.
- Brieflands has been registered as a General partnership (Vennootschap onder firma) company in the Chamber of Commerce (Kamer van Koophandel) of the Netherlands since 2010.
- KvK number: 89235444.
- BTW (VAT) number: NL864918896B01 (check online at VIES)
- RSIN: 864918896
- Nedmedica is our related company which is specialized in Author Services.
- Our former branding name was Kowsarmedical Publishing (2010-2021).
Communities in Brieflands
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Recent Submissions
Mobile Learning: Bridging Gaps and Providing Insights in Primary Healthcare Practices
(Brieflands, 2026-12-31) Masomeh Kalantarion; Amirreza Allahgholipour; Soleiman Ahmady; Hasnain Zafar Baloch; Zahra Shekarriz Foomany; Masomeh Kalantarion [0000-0003-4778-3973]; Amirreza Allahgholipour [0000-0002-7842-9398]; Soleiman Ahmady [0000-0003-0551-6068]; Hasnain Zafar Baloch [0000-0003-0839-1328]; Zahra Shekarriz Foomany [0009-0000-2065-2979]
Context: Mobile learning (mLearning) has gained increasing recognition as an effective tool for advancing primary healthcare education, particularly in resource-limited settings. Its flexibility and accessibility offer new opportunities for healthcare workers (HCWs) and medical students to acquire and update clinical knowledge. Evidence Acquisition: A comprehensive literature search was performed in Web of Science, ERIC, PubMed, and Scopus for studies published between 2015 and August 10, 2025. Keywords included mobile learning, primary healthcare, and healthcare workers. The inclusion criteria comprised peer-reviewed, English-language articles that examined mLearning applications in primary healthcare and reported empirical data. Nonrelevant, non-peer-reviewed, and methodologically weak studies were excluded. Results: The findings indicate that mLearning enhances continuing education, facilitates peer collaboration, and improves patient management, particularly during public health emergencies such as the COVID-19 pandemic. Mobile applications tailored to specific healthcare contexts enable HCWs to remain up to date with evolving clinical guidelines and empower patients by improving their medical literacy. Despite persistent challenges, including the financial burden of mobile devices and variability in technological proficiency, mLearning demonstrates substantial potential to reduce the economic costs of healthcare education while strengthening the healthcare workforce. Conclusions: mLearning is a promising strategy for bridging educational gaps and enhancing healthcare delivery in primary healthcare settings. However, challenges remain, including device costs, connectivity constraints, and technological inequity. Strategic integration into curricula, together with investment in digital infrastructure, could improve the training of healthcare workers, empower patients, and enhance the quality of care. Future studies should incorporate follow-up periods, cost-effectiveness analyses, and implementation strategies to ensure equitable and sustainable impact.
Advances in Management of Rheumatoid Arthritis: From Conventional Therapy to Targeted Treatment – A Narrative Review
(Brieflands, 2026-06-30) Nauman Ismat Butt; Tashia Malik; Umaima Waris; Nauman Ismat Butt [0000-0003-1022-0157]; Umaima Waris [0009-0009-4610-9056]
Context: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease affecting approximately 0.5%–1% of the global population. It is characterized by persistent synovial inflammation, predominantly involving the small joints in a symmetrical pattern, progressive joint destruction, and substantial functional disability. The pathogenesis of RA involves genetic predisposition, environmental triggers, and immune dysregulation, leading to the activation of T cells, B cells, and proinflammatory cytokines, including TNF-α, IL-1, and IL-6. Evidence Acquisition: Advances in understanding the mechanisms of RA have led to substantial improvements in management strategies. Results: Current treatment approaches emphasize prompt diagnosis, early initiation of disease-modifying antirheumatic drugs (DMARDs), and a treat-to-target strategy aimed at achieving remission or low disease activity. Conventional DMARDs, particularly methotrexate, remain the cornerstone of therapy, whereas biologic agents and targeted synthetic DMARDs, such as JAK inhibitors, provide options for refractory disease. Nonpharmacological interventions and lifestyle modifications may further improve outcomes. Despite substantial therapeutic progress, delayed diagnosis, limited access to advanced therapies, and high treatment costs continue to impede optimal disease management, particularly in resource-limited settings. Conclusions: This narrative review summarizes current treatment strategies, recent therapeutic advances, and key healthcare barriers relevant to improving rheumatoid arthritis outcomes globally and in developing-country contexts. It emphasizes conventional disease-modifying therapies, biologic and targeted synthetic agents, and treat-to-target approaches; highlights major challenges in resource-limited settings, particularly Pakistan; and discusses evolving strategies to improve long-term patient outcomes.
Comparison of Co-amoxiclav Removal from Aqueous Solutions Using Spirulina platensis Microalgae and Manganese Molybdate-Modified Spirulina Biochar
(Brieflands, 2026-07-31) Hossein Rostamian; Jaleh Mohajeri Borazjani; Hakimeh Fekrandish; Hossein Rostamian [0009-0001-4149-3185]; Jaleh Mohajeri Borazjani [0000-0002-7612-0397]; Hakimeh Fekrandish [0000-0002-2526-6935]
Background: The release of antibiotics into aquatic environments, particularly co-amoxiclav, poses a serious threat to ecosystem integrity and human health. Therefore, developing efficient bio-based adsorbents to remove these persistent compounds is critically important. Objectives: The primary objective of this study was to compare the removal of co-amoxiclav from aqueous solutions using Spirulina platensis microalgae and manganese molybdate-modified Spirulina biochar. Methods: In this study, three adsorbents were evaluated: live Spirulina platensis, biochar derived from Spirulina, and biochar modified with MnMoO4 nanostructures. The modified biochar was synthesized by the controlled precipitation of MnMoO4 onto the biochar surface. The adsorbents were characterized using Brunauer-Emmett-Teller (BET) surface area analysis, Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), and field-emission scanning electron microscopy (FE-SEM). Batch adsorption experiments (n = 90) were conducted under varying pH values (3 - 11), contact times (10 - 240 min), and initial co-amoxiclav concentrations (5 - 100 mg/L). Residual co-amoxiclav concentrations were determined using UV-visible (UV-vis) spectrophotometry. Results: BET analysis showed that the modification increased the biochar’s specific surface area (185.4 m2/g), pore volume (0.238 cm3/g), and average pore diameter (5.14 nm). FTIR and XRD confirmed the formation of stable metal–oxygen bonds and the crystalline MnMoO4 phase. FE-SEM images revealed increased surface roughness and the formation of rod-like and flower-like nanoparticle morphologies. At approximately neutral pH, the highest removal efficiencies were observed: 84% for MnMoO4-modified biochar, 76% for raw biochar, and 64% for live Spirulina. The time-dependent decrease in co-amoxiclav concentration indicated a multistep uptake mechanism involving surface adsorption, electrostatic interactions, metal complexation, and π–π interactions. Conclusions: MnMoO4-modified Spirulina biochar can be considered an efficient, stable, and promising adsorbent for advanced treatment of pharmaceutical wastewater containing co-amoxiclav.
Naringin Administration Is Associated with Reduced Reproductive Toxicity Following Subchronic Low-Dose Chlorpyrifos Exposure in Rats
(Brieflands, 2026-12-31) Solale Ramzani; Seyed Bagher Mortazavi; Mohammad Shokrzade; Ali Khavanin; Solale Ramzani [0000-0002-9233-5072]; Mohammad Shokrzade [0000-0002-0071-6530]; Ali Khavanin [0000-0002-1792-2488]
Background: Male infertility is increasingly associated with environmental and occupational exposure to organophosphate pesticides, particularly chlorpyrifos (CPF). Cchlorpyrifos persists in food, water, and the environment, resulting in chronic low-dose exposure. Although the toxic effects of high-dose exposure are well documented, the reproductive consequences of subchronic low-dose exposure remain unclear. Objectives: To evaluate whether intraperitoneal administration of naringin attenuates CPF-induced reproductive toxicity in adult male rats by assessing sperm parameters, serum reproductive hormones, oxidative stress markers, and testicular histopathology. Methods: Adult male rats were assigned to six groups (n = 5 per group): Control, naringin control (200 mg/kg), CPF (8 mg/kg), and CPF plus naringin (50, 100, or 200 mg/kg). Sperm count, motility, and morphology; serum testosterone, luteinizing hormone, and follicle-stimulating hormone levels; testicular malondialdehyde, reactive oxygen species, glutathione, and superoxide dismutase levels; and histopathological changes were assessed. Results: Chlorpyrifos exposure was associated with impaired sperm count, motility, and morphology; reduced reproductive hormone levels; increased oxidative stress; and testicular histological damage. Naringin pretreatment was associated with dose-dependent improvements in sperm parameters, partial restoration of hormonal balance, improvement in oxidative stress markers, and preservation of testicular histology, with more pronounced effects at 100 and 200 mg/kg. Conclusions: Naringin administration was associated with attenuation of CPF-induced reproductive alterations and improved oxidative stress markers and hormonal parameters. These findings support further investigation of naringin for pesticide-induced male reproductive dysfunction; however, validation in humans is required. The limited range of naringin doses and the absence of molecular investigations highlight the need for further studies to elucidate the underlying mechanisms and translational relevance to human reproductive health.
Histopathological and Immunohistochemical Changes in Coronary Arteries Following Percutaneous Coronary Intervention in Patients Undergoing Coronary Artery Bypass Grafting
(Brieflands, 2026-06-30) Mahmood Beheshti Monfared; Atoosa Gharib; Sahand Abrishami; Mahmood Beheshti Monfared [0000-0002-1874-4273]
Background: Coronary artery disease (CAD) is a leading indication for coronary artery bypass grafting (CABG). Many patients undergo percutaneous coronary intervention (PCI) with stent implantation before subsequently requiring CABG. Objectives: This study aimed to evaluate and compare histopathological and immunohistochemical changes in the coronary artery walls of CABG candidates with and without a history of PCI. Methods: In this case-control study, patients with CAD undergoing CABG were allocated to two groups based on their history of PCI. During surgery, coronary artery tissue specimens were obtained from the arteriotomy edge at the distal anastomotic site. Histopathological evaluation included assessment of atherosclerotic plaques, endothelial injury, extracellular matrix degradation, and immunohistochemical expression of CD68, CD45RO, and α-smooth muscle actin (α-SMA). The frequencies of these pathological features were compared between the two groups. Results: Patients with a history of PCI exhibited significantly higher expression of the inflammatory markers CD68 and CD45RO and the proliferative marker α-SMA than the control group (P < 0.05). In contrast, no significant differences were observed between the groups in extracellular matrix degradation, collagen content, or the severity of endothelial injury. Furthermore, the timing of intervention (urgent vs emergent) was not associated with the extent of histopathological changes. Conclusions: PCI before CABG was associated with an active inflammatory state and an enhanced proliferative response in the coronary artery wall. These changes occurred in the absence of substantial structural disruption of the extracellular matrix, suggesting that coronary stenting induces persistent immune activation and vascular smooth muscle cell proliferation rather than overt tissue destruction.