The company was first founded by Seyyed M. Miri and Seyed-M Alavian as an editorial group in a Medical Institute in 2007 to publish its medical journal. After three years of experience, the number of journals increased to 5 journals, and the company launched its first form of business as a VOF (collaboration) professional STM company in Heerlen, the Netherlands, which was called "Kowsarmedical Publishing." Respecting the publishing services (from submission to publishing), especially an in-house "Journal Management System," our journals increased to more than 60 STM journals between 2010 and 2019. Since 2022, "Brieflands" is the new brand name that acts as a "Science, Technical, Medical Publisher" that publishes more than 50 journals with the services provided by 97 expert employees in three different branches.

Business Profile

  • Brieflands is a Registered Trademark with record number 1454012.
  • Brieflands has been registered as a General partnership (Vennootschap onder firma) company in the Chamber of Commerce (Kamer van Koophandel) of the Netherlands since 2010.
  • Nedmedica is our related company which is specialized in Author Services. 
  • Our former branding name was Kowsarmedical Publishing (2010-2021).

Recent Submissions

The Effectiveness of Acceptance and Commitment Therapy on the Meaning of Life and Psychological Capital of Male Students with Suicidal Ideation
(Brieflands, 2024-06-30) Mehrdad Pirfalak; Seyed Hamid Atashpour; Mohsen Golparvar
Background: Given the concerning prevalence of suicidal ideation among male students, exploring potential interventions like acceptance and commitment therapy (ACT) to improve their meaning of life and psychological well-being is crucial. Objectives: This research was conducted to evaluate the impact of ACT on enhancing life’s meaning and psychological capital among male students experiencing suicidal ideation. Methods: The research method was a quasi-experimental design with a pre-test and post-test control group. The statistical population consisted of all male high school students with suicidal thoughts during the 2022 - 2023 academic year in Izeh city. Out of these, 30 individuals were selected through the multistage cluster random sampling method and were then randomly assigned to the ACT group and the control group (15 individuals each). The instruments included the Meaning in Life Questionnaire (MLQ) and Psychological Capital Questionnaire (PCQ). Participants in the experimental group attended ACT sessions for 8 weeks (one 75-minute session per week), but no intervention was conducted in the control group. Research data were analyzed using analysis of covariance in SPSS-26. Results: The meaning in life scores for the ACT group were 33.60 ± 8.15 at pretest and increased to 41.20 ± 6.67 at posttest. Moreover, the psychological capital scores for the ACT group were 68.13 ± 13.28 at pretest and increased to 79.40 ± 8.61 at posttest. The results revealed significant improvements in both the meaning of life and psychological capital in the ACT group compared to the control group (P < 0.01). Specifically, the ACT intervention led to a significant increase in the meaning of life scores and psychological capital scores among male students experiencing suicidal ideation (P < 0.01). Conclusions: These findings indicate that ACT could help improve life meaning and well-being in students with suicidal ideation. Future studies could examine how ACT brings about these changes and look into its long-term impact.
Cytotoxicity of Fractions of Dracontium spruceanum Chloroform Extract in MDA-MB-231 and MCF-7 Breast Cancer Cell Lines
(Brieflands, 2024-05-27) Arlem Rodriguez-Huamani; Maria Medina-Calderon; Santiago Alvarez-Vega; Salyoc Tapia-Rojas; Alejandro Fukusaki-Yoshizawa; Ana Mayanga-Herrera
Background: Breast cancer is a major health issue responsible for numerous deaths worldwide. Medicinal plants are rich in compounds with potential anticancer properties. Objectives: This study aimed to assess the cytotoxicity of fractions from the Dracontium spruceanum chloroform extract on MDA-MB-231 and MCF-7 breast cancer cell lines. Methods: Eleven fractions were screened for cytotoxic effects on cell viability using the MTT assay. Subsequently, the two most cytotoxic fractions were selected, and the half-maximal inhibitory concentration (IC50) was calculated using two-fold dilution concentrations ranging from 100 to 1.56 µg/mL. Results: Fractions F43 and F50 showed the highest cytotoxicity at 100 µg/mL. The IC50 of F43 was 270.8 ± 18.07 µg/mL and 133.0 ± 17.99 µg/mL for MDA-MB-231, and 252.2 ± 21.94 µg/mL and 144.3 ± 23.14 µg/mL for MCF-7 cells at 24 and 48 hours, respectively. For F50, IC50 values were 107.2 ± 2.97 µg/mL and 126.1 ± 14.77 µg/mL for MDA-MB-231, and 236.4 ± 58.7 µg/mL and 104.5 ± 10.54 µg/mL for MCF-7 at corresponding times. Conclusions: Dracontium spruceanum fractions demonstrated moderate cytotoxicity on MDA-MB-231 and MCF-7 breast cancer cell lines, indicating their anticancer potential. Further research is required to identify the metabolites responsible for this activity and to elucidate the molecular mechanisms involved.
Antimicrobial Susceptibility Patterns of Escherichia coli Isolates from Hospitalized Patients with Different Infections in Isfahan, Iran: Impact on Empiric Antibiotic Therapy in Associated Infections
(Brieflands, 2023-07-31) Sayed Nassereddin Mostafavi Esfahani; Soodabeh Rostami; Shekoufe Poorshariat
Background: Escherichia coli is an important cause of urinary tract, bloodstream, and surgical site infections. Objectives: We investigated the organism's antibiotic susceptibility in hospitalized patients under different clinical conditions. Methods: This prospective study was conducted in three referral hospitals located in Isfahan, Iran. Different clinical samples were tested using standard routine microbiological methods to identify E. coli strains and determine their antibiotic susceptibility patterns by the disk diffusion method according to CLSI recommendations. After conducting a clinical investigation, contaminated samples were excluded, and the hospital or community source and infection site were identified. Data on antibiotic susceptibility testing were extracted using WHONET software. Data analysis was then conducted using SPSS Statistics version 18.0. Results: Of 1248 E. coli isolates, 71.9% were from urine, 15.1% from blood, and 7.8% from skin and soft tissue samples. High susceptibility was observed to Imipenem (98%), Meropenem (98.0%), and Amikacin (94.6%); intermediate sensitivity to Gentamicin (68.6%) and Cefepime (51.9%); and low susceptibility to Ceftazidime (46.8%), Ceftriaxone (41.3%), Ciprofloxacin (39.5%), Cefotaxime (39.3%), and Trimethoprim-sulfamethoxazole (32.4%). Conclusions: Antibiotics, including Imipenem, Meropenem, or Amikacin, would be beneficial in the empiric therapy of severe infections where E. coli is the main cause.
First Steps in Constructing the KVAD Score to Estimate the Risk of Dehydration in Children with Acute Diarrhea: A Case-Control Study
(Brieflands, 2024-05-31) Khai Quang Tran; Vi Van Tran; Nguyen Thao Ly; Hieu Trung Truong; Phuong Minh Nguyen
Background: Acute diarrhea is a worldwide health concern with a high mortality rate among children under five. Dehydration, a potentially fatal consequence of this illness, must be promptly identified. A scoring system is necessary to predict the degree of dehydration. Objectives: This study aims to identify risk factors and develop a scoring system with an appropriate cutoff to estimate the likelihood of dehydration in children with acute diarrhea. Methods: In this case-control study, the patient group comprised 34 children with acute diarrhea and dehydration, while the control group included 137 children with acute diarrhea without dehydration, admitted to the Gastroenterology Department of Can Tho Children's Hospital, Can Tho city, Vietnam, from November 2022 to October 2023. Results: Acute diarrhea with dehydration was associated with the following factors: Fever (OR 1.802, 95% CI 1.703 - 3.024, P = 0.026), frequency of diarrhea per day (OR 1.744, 95% CI 1.432 - 2.125, P < 0.001), frequency of vomiting per day (OR 1.242, 95% CI 1.102 - 1.399, P < 0.001), and weight-for-age > +2SD (OR 3.293, 95% CI 1.151 - 9.422, P = 0.026). Based on these four parameters and an area under the ROC curve of 0.889, a new scoring system known as the KVAD (K: Kelvin, V: Vomit, A: Avoirdupois, D: Diarrhea) score has been developed. A score of 21 was determined as the optimal cutoff point for identifying dehydration in children with acute diarrhea, with a sensitivity of 79.4% and specificity of 85.4%. Conclusions: The KVAD score represents the initial step in developing an effective and reliable screening tool for estimating the risk of dehydration in children with acute diarrhea.
ACE1-I/D Polymorphism in Patients With Severe COVID-19
(Brieflands, 2023-09-30) Fouzieh Karimi; Vahedeh Hosseini; Abbas Ahmadi; Fahimeh Ranjbar Kermani; Shirin Ferdowsi
Background: In several studies, insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme 1 (ACE1) gene is described as a genetic risk factor for coronavirus disease 2019 (COVID-19) infection. However, in some studies, this contribution is not confirmed. Therefore, this study aimed to evaluate the genotypic and allelic frequency of ACE1-D/I in Kurdish patients with severe COVID-19 in Iran. Methods: A total of 95 patients with PCR positive-COVID-19 were enrolled in this cross-sectional study. Genomic DNA was extracted from peripheral blood leucocytes using the salting out method. All cases were genotyped for ACE1-I/D polymorphism using polymerase chain reaction (PCR). Death percentage from COVID-19 after two months? follow-up was analyzed.?Results: Of?the 95 patients, 48 were female (50.5%) and 47 were male (49.5%) with a mean age of 61.9?18.7 years. The ID genotype was the most prevalent (52.6%) followed by DD (32.6%) and II (14.7%). The D and I allele frequencies were 58.9%, and 41.1%, respectively. The D allele frequency was higher in patients with SpO2?90% (P = 0.048). The mortality percentage was 18.9% (8 females and 10 males). The frequency of the DD, ID, and II genotypes in patients who died from COVID-19 was 27.7%, 61,1%, and 11.1%. Conclusions: Our results indicated that the ACE1- D allele can be a genetic risk factor in COVID-19 patients. Further studies on different ethnicities and geographical regions are needed to evaluate this polymorphism in COVID-19 infection.