Brieflands

History

The company was first founded by Seyyed M. Miri and Seyed-M Alavian as an editorial group in a Medical Institute in 2007 to publish its medical journal. After three years of experience, the number of journals increased to 5 journals, and the company launched its first form of business as a VOF (collaboration) professional STM company in Heerlen, the Netherlands, which was called "Kowsarmedical Publishing." Respecting the publishing services (from submission to publishing), especially an in-house "Journal Management System," our journals increased to more than 60 STM journals between 2010 and 2019. Since 2022, "Brieflands" is the new brand name that acts as a "Science, Technical, Medical Publisher" that publishes more than 50 journals with the services provided by 97 expert employees in three different branches.

Business Profile

  • Brieflands is a Registered Trademark with record number 1454012.
  • Brieflands has been registered as a General partnership (Vennootschap onder firma) company in the Chamber of Commerce (Kamer van Koophandel) of the Netherlands since 2010.
  • Nedmedica is our related company which is specialized in Author Services. 
  • Our former branding name was Kowsarmedical Publishing (2010-2021).
 

Communities in Brieflands

Select a community to browse its collections.

Recent Submissions

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A Novel Therapeutic Approach for High-Risk and Relapsed/Refractory Neuroblastoma: Dinutuximab Beta
(Brieflands, 2026-02-28) Elif Habibe Aktekin; Nalan Yazıcı; Ayşe Erbay; Murat Ozkale; Elif Habibe Aktekin [0000-0002-0394-6219]; Nalan Yazıcı [0000-0003-4465-8229]; Ayşe Erbay [0000-0001-7292-3822]; Murat Ozkale [0000-0003-0625-1057]
Background: Survival of patients in the high-risk group and those with relapsed/refractory neuroblastoma is significantly low. For these patients, results obtained with dinutuximab beta are promising. Objectives: In this study, we retrospectively analyzed our experience with dinutuximab beta in high-risk and relapsed/refractory neuroblastoma. Methods: Dinutuximab beta was given alternating with 13-cis retinoic acid as a component of maintenance therapy for high-risk group patients, and with 13-cis retinoic acid or a chemotherapy regimen for relapsed patients, with a continuous infusion at a dose of 10 mg/m2/day for 10 days. Adverse effect profiles and outcomes of patients were also examined. Results: Between March 2021-February 2023, 6 patients were treated for high-risk disease and 2 for relapsed disease with dinutuximab beta. Of all patients, seven are alive. One patient died due to severe capillary leak syndrome. The most common adverse effects during dinutuximab beta administration were fever, pain, and tachycardia, respectively. All adverse effects were managed without serious problems, except for the patient who had severe capillary leak. Pupil paralysis occurred as an unusual adverse effect. Conclusions: As a result of this study, dinutuximab beta can be an effective and reliable option in addition to standard treatment for patients diagnosed with high-risk and relapsed/refractory neuroblastoma compared with previous experience. However, especially in cases with pulmonary problems such as bronchopulmonary dysplasia, this drug should be carefully reassessed because of the irreversible adverse effect of capillary leak syndrome.
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Breastfeeding As a Protective Factor for Childhood Obesity
(Brieflands, 2026-02-28) Sabina Catic; Agima Ljaljevic; Enisa Kujundzic; Muhedin Kadic Dino; Vilnerina Ramcilovic
Background: Numerous studies indicate that weight gain during early childhood is strongly associated with obesity later in life, as well as with adult morbidity. There is increasing evidence suggesting that breastfeeding provides protection against the development of overweight and obesity in young children and adolescents. Objectives: The aim of this study was to determine whether breastfeeding and its duration are related to obesity in children, assessed through anthropometric parameters: Body Mass Index (BMI), head circumference, upper arm circumference, skinfold thickness, and chest circumference, in children aged 0 to 5 years in Montenegro. Methods: A cross-sectional study was conducted on a representative sample of 7.811 children aged 0 to 5 years, of both genders. Data collection involved anthropometric measurements, including height, head circumference, upper arm circumference, chest circumference, skinfold thickness, and body weight. These measurements were recorded in standardized protocols alongside a questionnaire designed for this specific research, which included questions on breastfeeding status, duration, and any chronic disease diagnoses. The questionnaire was completed by parents or guardians. The study was conducted in pediatric counseling clinics in primary healthcare centers, preschool institutions, and maternity departments in Montenegro. Correlation analyses and linear regression analyses were conducted to examine the association between breastfeeding and standardized anthropometric parameters. In the regression analyses, breastfeeding was treated as a dichotomous variable (breastfeeding status), a continuous variable (duration in months), and a categorical variable, in order to assess the consistency of the observed effects. The regression models were first analyzed without adjustment (univariate models) and subsequently adjusted for sex and age as potential confounding variables, as well as for their combined effect. Results: Among the total sample, breastfed children (76.7%) had significantly lower mean values for head circumference, upper arm circumference, and chest circumference compared to non-breastfed children (23.3%) (P < 0.00). Gender-based analysis yielded similar results. The average values of anthropometric parameters in non-breastfed children were lower than in children breastfed for 0 - 6 months but higher than in children breastfed for more than 6 months. Regression analysis demonstrated a significant influence of breastfeeding and breastfeeding duration on anthropometric parameters. Breastfeeding status had the greatest effect on head circumference (0.070), upper arm circumference (0.067), and chest circumference (0.044), while breastfeeding duration significantly impacted BMI (0.125), body weight (0.121), head circumference (0.103), height (0.099), and chest circumference (0.048). Conclusions: The results indicate that breastfeeding is a significant predictor of obesity in later life in both genders.
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Analysis of the Characteristics and Quality Indicators of Pediatric Patients at Pediatric Specialized Emergency Medical Centers
(Brieflands, 2026-02-28) Eul Hee Roh; Young Jin Huh; Han Na Lee; Yu Kyung Kwon; Mi Ra Oh
Background: Despite a declining pediatric population due to reduced birth rates, the demand for pediatric emergency medical services continues to increase. Pediatric patients require age-specific care that differs considerably from adult emergency care. To address this need, Pediatric Specialized Emergency Medical Centers (PSEMCs) have been operational in Korea since 2016. Objectives: This study aimed to evaluate the effectiveness of PSEMCs by analyzing the impact of their designation on patient characteristics and emergency care quality indicators. Methods: This cross-sectional study utilized 2022 data from the National Emergency Department Information System (NEDIS), including patients under 18 years of age with Korean Triage and Acuity Scale (KTAS) levels 1 - 3 who were diagnosed with severe pediatric diseases. Patient demographics and emergency care quality indicators were compared between PSEMC-designated and non-designated emergency institutions using cross-tabulation, logistic regression, the Mann-Whitney test, and proportion tests. Results: Pediatric Specialized Emergency Medical Centers treated a higher proportion of younger patients (aged 0 - 11 years; 85.6%), high-acuity cases (KTAS levels 1 - 2; 33.6%), and illness-related visits (94.0%) compared with general emergency institutions. Pediatric Specialized Emergency Medical Centers utilization was significantly associated with visits via other vehicles (76.9%), more frequent face-to-face care from pediatric specialists (94.1%), higher discharge rates (46.0%), and lower inter-hospital transfer rates (1.6%). These factors were significantly associated with increased PSEMC utilization. Although PSEMCs showed a longer median emergency department (ED) length of stay (4.5 hours) and a higher proportion of patients staying in the ED for over 24 hours (1.8%), they demonstrated better clinical outcomes, including lower transfer rates (1.6%) and higher final treatment provision rates (46.2%). Conclusions: Pediatric Specialized Emergency Medical Centers play a critical role in the care of severely ill pediatric patients and are associated with improved treatment outcomes. However, the high volume of patients with less severe conditions may limit optimal resource utilization. Enhancing severity-based triage, care delivery systems, and targeted policy interventions may further improve the effectiveness of PSEMCs.
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Characterization of Emulsification Profiles of Developed Lipid Formulation for the Oral Delivery of Poorly Water-Soluble Drugs
(Brieflands, 2026-12-31) Naser Hasan; Raniya S Bakhsh; Abdullah H Shabakh; Dina H. Aldhahri; Mohammed Y. Dakkak; Manal S. AL-Harbi; Raneem A. Alobydan
Background: The design of robust self-micro-emulsifying lipid formulations to enhance the bioavailability of poorly water-soluble drugs requires studying the interaction between the type of oil, co-surfactant, and type of surfactant. These blended constituents control the hydrophilicity of the lipid vehicle, drug solubility in the lipid matrix, and the physicochemical state of the drug after dispersion. Objectives: Archetypical lipid class systems were formulated, and the resultant aqueous dispersions were characterized. Ternary miscibility diagrams and physicochemical properties of the resultant dispersions with and without model drug were analyzed. Methods: Various lipid mixtures were blended by varying key elements in the vehicle composite, which include the type of oil, co-surfactant, and surfactant. Miscibility and equilibrium aqueous dispersion profiles were mapped out to screen for microemulsions. Solubility profiles of various drugs were studied in varying lipid compositions. Results: At minimal ratios of {soybean/cremophore} (1:9) or {span 80/tween 80} (2:8), only 10% w/w of tween 20 is required to obtain microemulsion dispersions. Whereas, in the case of glycerox/tween 20/cremophor RH40, a complete region of clear emulsions was obtained at all ratios. Conclusions: Robust microemulsion lipid systems are fabricated to mimic the absorption of poorly water-soluble compounds with minimal tendency for drug recrystallization in situ after aqueous dispersion.
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Size-Tunable Agarwood-Oil–Loaded Chitosan Nanoparticles for Sustainable Biofunctional Textiles
(Brieflands, 2026-12-31) Azri Farhanah Abd Aziz; Manuel Jose Lis Arias; Haliza Katas; Haliza Katas [0000-0001-7249-1628]
Background: Nanoparticle size is a critical factor influencing diffusion behavior, interfacial interactions, and overall performance in biomedical and textile-based delivery systems. Aquilaria malaccensis (agarwood) oil (AO), an essential oil of cultural and commercial significance in Malaysia, has unique bioactive properties but remains underexplored in nanoparticle formulations due to challenges related to its volatility and poor water compatibility. Objectives: This study aims to develop a sustainable, size-tunable chitosan-based nanocarrier capable of efficiently encapsulating AO and to evaluate its physicochemical characteristics and compatibility with textile substrates for potential biomedical and functional textile applications. Methods: AO-loaded chitosan nanoparticles were produced using an emulsion-assisted ionic-gelation method, employing chitosan and sodium tripolyphosphate (TPP) without organic solvents. Particle size was modulated across a predefined design space. The optimised nanoparticle formulation was characterised for size, Polydispersity Index (PDI), zeta potential, encapsulation efficiency, loading capacity, and process yield. The optimised nanoparticles were subsequently applied onto cotton and polyester fabrics to assess wet pickup and incorporation behaviour. Results: The fabrication method produced nanoparticles ranging from 78.6 to 2425 nm with PDI values below 0.35. The optimised formulation yielded uniform particles of approximately 90.75 nm with a zeta potential of +17.6 mV, an encapsulation efficiency of 80.23%, a loading capacity of 24.84%, and a process yield of 15.49%. These properties indicate effective incorporation of hydrophobic AO within the chitosan–TPP matrix. When applied to textile substrates, the nanoparticles demonstrated favourable wet pickup and incorporation profiles on both cotton and polyester. Conclusions: Overall, this work presents a sustainable and size-tunable chitosan-based nanocarrier capable of incorporating AO, highlighting its promise for future development in dermal, pharmaceutical, and biofunctional textile applications. Future research will focus on evaluating biological activity, release behavior, and textile performance, thereby establishing the practical impact and broad applicability of these nanoparticles across diverse real-world scenarios.