Brieflands

History

The company was first founded by Seyyed M. Miri and Seyed-M Alavian as an editorial group in a Medical Institute in 2007 to publish its medical journal. After three years of experience, the number of journals increased to 5 journals, and the company launched its first form of business as a VOF (collaboration) professional STM company in Heerlen, the Netherlands, which was called "Kowsarmedical Publishing." Respecting the publishing services (from submission to publishing), especially an in-house "Journal Management System," our journals increased to more than 60 STM journals between 2010 and 2019. Since 2022, "Brieflands" is the new brand name that acts as a "Science, Technical, Medical Publisher" that publishes more than 50 journals with the services provided by 97 expert employees in three different branches.

Business Profile

  • Brieflands is a Registered Trademark with record number 1454012.
  • Brieflands has been registered as a General partnership (Vennootschap onder firma) company in the Chamber of Commerce (Kamer van Koophandel) of the Netherlands since 2010.
  • Nedmedica is our related company which is specialized in Author Services. 
  • Our former branding name was Kowsarmedical Publishing (2010-2021).
 

Communities in Brieflands

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Recent Submissions

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Characterization of Emulsification Profiles of Developed Lipid Formulation for the Oral Delivery of Poorly Water-Soluble Drugs
(Brieflands, 2026-12-31) Naser Hasan; Raniya S Bakhsh; Abdullah H Shabakh; Dina H. Aldhahri; Mohammed Y. Dakkak; Manal S. AL-Harbi; Raneem A. Alobydan
Background: The design of robust self-micro-emulsifying lipid formulations to enhance the bioavailability of poorly water-soluble drugs requires studying the interaction between the type of oil, co-surfactant, and type of surfactant. These blended constituents control the hydrophilicity of the lipid vehicle, drug solubility in the lipid matrix, and the physicochemical state of the drug after dispersion. Objectives: Archetypical lipid class systems were formulated, and the resultant aqueous dispersions were characterized. Ternary miscibility diagrams and physicochemical properties of the resultant dispersions with and without model drug were analyzed. Methods: Various lipid mixtures were blended by varying key elements in the vehicle composite, which include the type of oil, co-surfactant, and surfactant. Miscibility and equilibrium aqueous dispersion profiles were mapped out to screen for microemulsions. Solubility profiles of various drugs were studied in varying lipid compositions. Results: At minimal ratios of {soybean/cremophore} (1:9) or {span 80/tween 80} (2:8), only 10% w/w of tween 20 is required to obtain microemulsion dispersions. Whereas, in the case of glycerox/tween 20/cremophor RH40, a complete region of clear emulsions was obtained at all ratios. Conclusions: Robust microemulsion lipid systems are fabricated to mimic the absorption of poorly water-soluble compounds with minimal tendency for drug recrystallization in situ after aqueous dispersion.
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Size-Tunable Agarwood-Oil–Loaded Chitosan Nanoparticles for Sustainable Biofunctional Textiles
(Brieflands, 2026-12-31) Azri Farhanah Abd Aziz; Manuel Jose Lis Arias; Haliza Katas; Haliza Katas [0000-0001-7249-1628]
Background: Nanoparticle size is a critical factor influencing diffusion behavior, interfacial interactions, and overall performance in biomedical and textile-based delivery systems. Aquilaria malaccensis (agarwood) oil (AO), an essential oil of cultural and commercial significance in Malaysia, has unique bioactive properties but remains underexplored in nanoparticle formulations due to challenges related to its volatility and poor water compatibility. Objectives: This study aims to develop a sustainable, size-tunable chitosan-based nanocarrier capable of efficiently encapsulating AO and to evaluate its physicochemical characteristics and compatibility with textile substrates for potential biomedical and functional textile applications. Methods: AO-loaded chitosan nanoparticles were produced using an emulsion-assisted ionic-gelation method, employing chitosan and sodium tripolyphosphate (TPP) without organic solvents. Particle size was modulated across a predefined design space. The optimised nanoparticle formulation was characterised for size, Polydispersity Index (PDI), zeta potential, encapsulation efficiency, loading capacity, and process yield. The optimised nanoparticles were subsequently applied onto cotton and polyester fabrics to assess wet pickup and incorporation behaviour. Results: The fabrication method produced nanoparticles ranging from 78.6 to 2425 nm with PDI values below 0.35. The optimised formulation yielded uniform particles of approximately 90.75 nm with a zeta potential of +17.6 mV, an encapsulation efficiency of 80.23%, a loading capacity of 24.84%, and a process yield of 15.49%. These properties indicate effective incorporation of hydrophobic AO within the chitosan–TPP matrix. When applied to textile substrates, the nanoparticles demonstrated favourable wet pickup and incorporation profiles on both cotton and polyester. Conclusions: Overall, this work presents a sustainable and size-tunable chitosan-based nanocarrier capable of incorporating AO, highlighting its promise for future development in dermal, pharmaceutical, and biofunctional textile applications. Future research will focus on evaluating biological activity, release behavior, and textile performance, thereby establishing the practical impact and broad applicability of these nanoparticles across diverse real-world scenarios.
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Synthesis, Cytotoxicity, and Structure Activity Relationship SAR of Novel Azo Substituted Pyrazoles
(Brieflands, 2026-12-31) Khaled Mohammed Alseud; Khaled Mohammed Alseud [0000-0002-2792-8648]
Background and Objective: Despite the urgent demand for the discovery of novel anticancer agents, anticancer discovery and development remain limited. Azo-containing compounds have emerged as attractive candidates in the field of anticancer drug discovery due to their distinctive reductive metabolism, which may be exploited to enhance anticancer efficacy and selectivity. Accordingly, increasing attention has been directed toward exploring the therapeutic potential of azo-aromatic scaffolds. Methods: In the present study, condensation reactions between benzoyl acetone and various aromatic diazonium salts were carried out to afford four azo derivatives, namely E-2-4-bromophenyldiazenyl-1-phenylbutane-1,3-dione KA101, E-1-phenyl-2-phenyldiazenylbutane-1,3-dione KA102, E-2-4-methoxyphenyldiazenyl-1-phenylbutane-1,3-dione KA103, and E-2-4-nitrophenyldiazenyl-1-phenylbutane-1,3-dione KA104. Subsequent cyclization of these azo precursors provided the corresponding phenyl pyrazole derivatives, designated KA5, KA6, KA7, and KA8, respectively Results: Previously, KA5 exhibited promising anticancer activity against the human hepatocellular carcinoma cell line HepG2. The biological evaluation demonstrated that the newly synthesized KA7 is more potent than KA5, indicating that compounds exhibiting a higher propensity to exist in the hydrazone tautomeric form, particularly KA5 and KA7, showed enhanced cytotoxic activity against HepG2 cells compared with other analogues. Conclusions: These findings demonstrate that both pyrazole ring formation and tautomeric preference significantly influence anticancer activity, supporting azo-pyrazole scaffolds as promising leads for further optimization in anticancer drug development.
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Folic Acid Ameliorates the Chronic Constriction Injury of Sciatic Nerve -Induced Memory Impairments in Rats
(Brieflands, 2026-12-31) Arunachalam Muthuraman; Mohamed Meeran Sheik Davooth; Seema Mehdi; Nallupillai Paramakrishnan; Satbir Kaur; Thiagharajan Venkata Rathina Kumar; Khian Giap Lim; Yamunna Paramaswaran; Arunachalam Muthuraman [0000-0002-0394-6104]; Mohamed Meeran Sheik Davooth [0009-0002-8377-1371]; Seema Mehdi [0000-0002-3212-0774]; Nallupillai Paramakrishnan [0000-0002-8219-4624]; Satbir Kaur [0009-0003-1235-501X]; Thiagharajan Venkata Rathina Kumar [0009-0007-7554-4204]; Khian Giap Lim [0000-0003-2746-5185]; Yamunna Paramaswaran [0009-0001-9144-9123]
Background and Objective: The present study investigated the effect of folic acid in a rat model of sciatic nerve injury (SNI)-induced cognitive dysfunction. Methods: In this study, six groups with six male Wistar rats in each group were used. The simple randomization method was adopted for unbiased assignment of animals based on age, sex, and weight variations. Folic acid (10 and 20 mg/kg) and donepezil (1 mg/kg) were administered by the oral (p.o.) route for 10 days. The rats' cognition was assessed by the Morris water maze (MWM) test. The assessment of the learning trial (acquisition) was the escape latency time (ELT), while the assessment of memory retention (retrieval) was the time spent in the target quadrant (TSTQ), which was measured in the MWM test. The brain samples of rats were used to assess biomarkers such as total protein, reduced glutathione (GSH), thiobarbituric acid reactive substances (TBARS), and acetylcholinesterase (AChE) activity. The behavioral data were statistically analyzed by a two-way analysis of variance (ANOVA) test, and biomarkers were analyzed by one-way ANOVA. The 95% confidence level (P < 0.05) was fixed for confirmation of statistical significance. Results: The administration of folic acid statistically (P < 0.05) reduced the SNI-induced elevated ELT and TSTQ levels compared to the sham control group. However, folic acid also prevented the rise in TBARS and AChE activity and the drop in GSH after SNI. The comparable outcomes were statistically (P < 0.05) similar to those of the donepezil-administered group. Conclusions: Folic acid has great potential to be used in treating peripheral nerve injury-associated cognitive dysfunction.
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Pharmacological SIRT2 Inhibition by AGK2 Attenuates Hapten-Induced Keratinocyte Inflammation via NF-κB/NLRP3 Suppression and Nrf2 Reactivation
(Brieflands, 2026-12-31) Xianhua Qiao; Xinglong Yu; Juanjuan Gao; Chong Lv; Fang Cheng; Xianhua Qiao [0009-0002-1215-048X]; Xinglong Yu [0009-0004-4255-7269]; Juanjuan Gao [0009-0000-2240-4370]; Fang Cheng [0009-0008-9609-1758]
Background: Allergic contact dermatitis (ACD) is initiated by hapten-induced keratinocyte oxidative stress and inflammatory signaling, commonly involving NF-κB activation, NLRP3 inflammasome priming–associated signaling, and inadequate Nrf2-dependent antioxidant responses. Identification of druggable upstream regulators that integrate these pathways could support host-directed pharmacological strategies for dermatitis-like inflammation. Objective: To investigate whether pharmacological inhibition of SIRT2 using AGK2 mitigates hapten-triggered inflammatory–oxidative stress signaling in human keratinocytes and to define the associated molecular mechanisms. Methods: Human Ker-CT keratinocytes were cultured alone or in transwell co-culture with CCD-1064Sk dermal fibroblasts and stimulated with 2,4-dinitrochlorobenzene (DNCB); nickel sulfate served as a comparator sensitizer. Cells were treated with the selective SIRT2 inhibitor AGK2, and target engagement was verified by acetyl-α-tubulin accumulation. Outcomes included viability (MTT), ROS generation (DCFDA), cytokine expression/secretion (qPCR/ELISA), and pathway signaling (Western blotting, immunofluorescence, nuclear–cytoplasmic fractionation), focusing on NF-κB (p65/IκBα), NLRP3 priming–associated readouts (NLRP3 expression and IL-1 family cytokine output), and Nrf2 localization with downstream antioxidant enzymes (HO-1, SOD). To strengthen specificity beyond pharmacological inhibition, SIRT2 involvement was genetically validated using siRNA-mediated knockdown (siSIRT2) in Ker-CT cells. In addition, AGK2-alone control groups (without DNCB) were included across major readouts to assess baseline effects on NF-κB, ROS, and Nrf2 signaling, and Keap1 expression was examined as mechanistic support for altered Nrf2 regulation. Results: DNCB produced a reproducible sub-toxic keratinocyte stress phenotype characterized by increased ROS, activation of NF-κB signaling with IκBα degradation and p65 nuclear translocation, upregulation of NLRP3 expression with elevated IL-1β/IL-18 secretion consistent with enhanced inflammasome-associated inflammatory responses, and impaired Nrf2 nuclear accumulation with reduced antioxidant enzyme expression. AGK2-mediated SIRT2 inhibition significantly attenuated NF-κB activation and reduced pro-inflammatory cytokine outputs, while reducing NLRP3 priming–associated responses and lowering IL-1β/IL-18 secretion. In parallel, AGK2 restored Nrf2 nuclear translocation and enhanced expression of HO-1 and SOD, resulting in partial normalization of intracellular redox balance. Importantly, siSIRT2 phenocopied AGK2 effects by reducing DNCB-induced NF-κB activation, ROS accumulation, and restoring nuclear Nrf2 enrichment. AGK2 alone did not significantly alter basal NF-κB signaling, ROS levels, or Nrf2 nuclear localization, supporting that AGK2 effects were stimulus-dependent rather than intrinsic pathway suppression. Consistent with impaired antioxidant competence under DNCB challenge, Keap1 levels increased with DNCB and were partially normalized by SIRT2 inhibition/knockdown, providing mechanistic context for the ROS–Nrf2 paradox. Conclusion: Pharmacological inhibition of SIRT2 with AGK2 is associated with anti-inflammatory and antioxidant effects in hapten-stimulated human keratinocytes, including attenuation of NF-κB signaling and reduction of NLRP3 priming–associated IL-1 family cytokine responses, together with restoration of Nrf2-dependent cytoprotective signaling. Collectively, these findings suggest that SIRT2 may have pharmacological relevance in ACD-like inflammatory skin stress and warrant further evaluation in preclinical dermatitis models and therapeutic development studies.