Brieflands

History

The company was first founded by Seyyed M. Miri and Seyed-M Alavian as an editorial group in a Medical Institute in 2007 to publish its medical journal. After three years of experience, the number of journals increased to 5 journals, and the company launched its first form of business as a VOF (collaboration) professional STM company in Heerlen, the Netherlands, which was called "Kowsarmedical Publishing." Respecting the publishing services (from submission to publishing), especially an in-house "Journal Management System," our journals increased to more than 60 STM journals between 2010 and 2019. Since 2022, "Brieflands" is the new brand name that acts as a "Science, Technical, Medical Publisher" that publishes more than 50 journals with the services provided by 97 expert employees in three different branches.

Business Profile

Brieflands is a Registered Trademark with record number 1454012.
Brieflands has been registered as a General partnership (Vennootschap onder firma) company in the Chamber of Commerce (Kamer van Koophandel) of the Netherlands since 2010.
- KvK number: 89235444.
- BTW (VAT) number: NL864918896B01 (check online at VIES )
- RSIN: 864918896
Nedmedica is our related company which is specialized in Author Services.
Our former branding name was Kowsarmedical Publishing (2010-2021).

Communities in Brieflands

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Recent Submissions

Non-coding RNAs in Cancer: From Computational Discovery to Functional Validation and Clinical Translation
(Brieflands, 2026-12-31)
Majid Mokhtari
;
Atieh Akbari
;
Majid Mokhtari [0000-0002-0927-6420]
;
Atieh Akbari [0000-0001-5628-0409]
This article does not have an abstract.
Re-evaluating the Concept of Peripheral Hypothyroidism
(Brieflands, 2027-01-31)
Fereidoun Azizi
;
Ali Siamak Moeini Habibi
;
Fereidoun Azizi [0000-0002-6470-2517]
;
Ali Siamak Moeini Habibi [0000-0002-4475-3333]
Context: Isolated peripheral hypothyroidism comprises a group of disorders in which cellular thyroid hormone action is impaired because of defects in membrane transport or intracellular metabolism, despite normal or increased thyroid hormone secretion. Because serum T4, T3, and TSH concentrations often remain within the normal range and sensitive markers of tissue thyroid status are lacking, diagnosis remains challenging. This review examines the causes of isolated peripheral hypothyroidism and recent advances in its management. Evidence Acquisition: A MEDLINE search covering 2010 - 2025 was conducted using the terms peripheral hypothyroidism, tissue-specific hypothyroidism, and cellular hypothyroidism, supplemented by manual screening of reference lists. After abstract screening, full-text articles were assessed for eligibility, duplicates were removed, and only studies with appropriate designs were included. Results: The causes can be categorized into four groups: 1) decreased peripheral T3 availability, as observed in patients receiving levothyroxine (LT4) monotherapy who have persistent symptoms associated with low serum T3:T4 ratios despite normal serum T4, T3, and TSH concentrations; 2) peripheral cellular dysfunction, reported in metabolic dysfunction-associated steatotic liver disease (MASLD), skeletal muscle changes during weight regain, and organ-specific conditions involving the heart, lungs, and kidneys, suggesting widespread tissue involvement; 3) altered deiodinase activity, including shifts toward reverse T3 production during cellular dysfunction and consumptive hypothyroidism caused by marked DIO3 overexpression in tumors such as hemangiomas; and 4) thyroid hormone receptor alterations, such as thyroid hormone receptor mutations causing resistance. Conclusions: Isolated peripheral hypothyroidism comprises a diverse and often underrecognized group of disorders because standard biochemical tests may appear normal. Promising therapies include thyroid hormone combinations, such as levothyroxine plus slow-release T3, and thyromimetics, such as resmetirom for MASLD. This review synthesizes recent findings on cellular hypothyroidism, diagnostic challenges, and emerging multidisciplinary management strategies. Improved biomarkers and multidisciplinary evaluation are still needed to advance its diagnosis and management.
Comparison of the Effects of Audible Guided Imagery and Self-selected Instrumental Music on Comfort and the Well-Being Index in Hemodialysis Patients: A Randomized Controlled Trial
(Brieflands, 2026-12-31)
Omidreza Siavash
;
Masoumeh Bagheri-Nesami
;
Abolfazl Hosseinnataj
;
Ravanbakhsh Esmaeili
;
Fatemeh Espahbodi
Background: Comfort and well-being are fundamental to the psychological health and life satisfaction of patients undergoing hemodialysis. Objectives: This study aimed to compare the effects of audible guided imagery (AGI) and self-selected instrumental music (SSIM) on comfort and well-being indices among patients undergoing hemodialysis. Methods: In this randomized controlled trial, 90 hemodialysis patients were allocated to 3 groups (n = 30 each): AGI, SSIM, and control, using sex-stratified block randomization. The interventions lasted 20 minutes per session, 3 times per week for 4 weeks, while the control group received routine care. Comfort and well-being were assessed at baseline and at the ends of weeks 2 and 4 using Kolcaba's Hospice Comfort Questionnaire and the World Health Organization Five Well-Being Index (WHO-5). Data were analyzed using SPSS version 22 with chi-square, Kruskal-Wallis, and Mann-Whitney tests and generalized estimating equations regression. Results: Baseline comfort and well-being scores did not differ significantly among the groups. However, both intervention groups showed significant improvements by the second and fourth weeks (P < 0.05). In the SSIM group, comfort scores increased from a baseline of 93.77 ± 13.81 to 116.90 ± 8.31 at week 2, reaching 121.60 ± 7.53 by week 4. The AGI group showed a similar trajectory, with comfort scores rising from 93.53 ± 13.08 at baseline to 117.60 ± 10.47 (week 2) and 121.90 ± 7.33 (week 4). Regarding well-being, the control group exhibited a slight downward trend over time (from 57.33 ± 23.36 to 50.27 ± 18.66). In contrast, the SSIM group showed a significant increase in well-being (from 64.80 ± 21.49 to 86.93 ± 9.45), as did the AGI group (from 65.87 ± 18.64 to 87.73 ± 10.02). The regression analysis showed that both intervention groups achieved significantly higher comfort and well-being scores over time than those in the control group. The models included the main effects of time and group and were adjusted for age, education, and diabetes. Conclusions: No statistically significant difference was detected between the two interventions in this sample; however, both SSIM and AGI can serve as effective nonpharmacological interventions to enhance comfort and subjective well-being in hemodialysis patients after 4 weeks.
From Stein-Leventhal to PMOS: Is It Time to Move Beyond the Ovary?
(Brieflands, 2027-01-31)
Fahimeh Ramezani Tehrani
;
Samira Behboudi-Gandevani
;
Fereidoun Azizi
;
Fahimeh Ramezani Tehrani [0000-0002-4609-065X]
;
Samira Behboudi-Gandevani [0000-0003-3526-640X]
This article does not have an abstract.
Assessment of HCV-RNA Testing Results and Genotype Distribution Among Anti-HCV-Positive Patients in Aksu Prefecture, Xinjiang, China: A Retrospective Hospital-Based Study
(Brieflands, 2026-12-31)
Hangchuan Mei
;
Gang Niu
;
Junsheng Ma
;
Hui Song
Background: Hepatitis C virus (HCV) is a major cause of chronic liver disease worldwide. However, local data on HCV RNA positivity and genotype distribution among anti-HCV-positive patients in Aksu Prefecture remain limited. Objectives: To describe HCV-RNA positivity and genotype distribution among anti-HCV-positive patients tested at a regional hospital in Aksu Prefecture and to evaluate demographic and geographic associations with HCV-RNA positivity. Methods: This retrospective hospital-based study included 4,735 independent anti-HCV-positive patients with valid HCV-RNA results at the Third People’s Hospital of Aksu Prefecture in 2024. Proportions were reported with Wilson 95% confidence intervals (CIs). A multivariable logistic regression model including sex, age group, and region was fitted to the individual-level analytical subset from eight regions (n = 3,842). Results: HCV RNA was detected in 1,361 of 4,735 anti-HCV-positive patients (28.74%; 95% CI, 27.47% - 30.05%). In the eight-region individual-level subset, 1,283 of 3,842 patients were HCV RNA-positive (33.39%; 95% CI, 31.92% - 34.90%). Male sex was associated with higher adjusted odds of HCV RNA positivity than female sex (adjusted odds ratio [aOR], 2.22; 95% CI, 1.91 - 2.57). Patients aged 31 - 40 years also had higher adjusted odds of HCV RNA positivity than those aged ≥ 61 years (aOR, 1.75; 95% CI, 1.41 - 2.16). Genotype 1b was the most frequent (41.59%), followed by 3a (26.60%), 2a (19.54%), and 3b (11.32%). Conclusions: HCV-RNA positivity and genotype distribution varied across demographic and geographic strata within this hospital-tested, anti-HCV-positive cohort. These estimates do not represent population-level prevalence in Aksu Prefecture.