Brieflands

History

The company was first founded by Seyyed M. Miri and Seyed-M Alavian as an editorial group in a Medical Institute in 2007 to publish its medical journal. After three years of experience, the number of journals increased to 5 journals, and the company launched its first form of business as a VOF (collaboration) professional STM company in Heerlen, the Netherlands, which was called "Kowsarmedical Publishing." Respecting the publishing services (from submission to publishing), especially an in-house "Journal Management System," our journals increased to more than 60 STM journals between 2010 and 2019. Since 2022, "Brieflands" is the new brand name that acts as a "Science, Technical, Medical Publisher" that publishes more than 50 journals with the services provided by 97 expert employees in three different branches.

Business Profile

  • Brieflands is a Registered Trademark with record number 1454012.
  • Brieflands has been registered as a General partnership (Vennootschap onder firma) company in the Chamber of Commerce (Kamer van Koophandel) of the Netherlands since 2010.
  • Nedmedica is our related company which is specialized in Author Services. 
  • Our former branding name was Kowsarmedical Publishing (2010-2021).
 

Communities in Brieflands

Select a community to browse its collections.

Recent Submissions

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Intermittent Fasting and Its Association with Metabolic, Inflammatory, and Fibrosis-Related Outcomes in Adults with Non-alcoholic Fatty Liver Disease: Findings from a Randomized Clinical Trial
(Brieflands, 2026-06-30) Morteza Aghajanpour Pasha; Vahid Mousavi; Sandra Saidi; Kayvan Baloochi; Niloofar Fathipour; Morteza Aghajanpour Pasha [0000-0002-7929-0551]; Vahid Mousavi [0009-0004-6625-0691]; Sandra Saidi [0000-0002-1398-063X]; Kayvan Baloochi [0009-0008-9633-8773]; Niloofar Fathipour [0009-0001-1934-487X]
Background: Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver dysfunction worldwide and commonly coexists with obesity, insulin resistance, and other metabolic disturbances. Lifestyle-based strategies remain central to disease management, and intermittent fasting has recently emerged as a potentially beneficial nutritional intervention. Objectives: This study aimed to evaluate whether intermittent fasting affects anthropometric measures, inflammatory biomarkers, fibrosis-related indices, and ultrasonographic manifestations of hepatic steatosis in individuals with NAFLD. Methods: This randomized clinical trial included 102 adults with ultrasonography-confirmed NAFLD who were randomly assigned in a 1:1 ratio to either a 16:8 intermittent fasting intervention or a control group for 12 weeks. Clinical and laboratory evaluations were performed at baseline and after the intervention. Outcomes included anthropometric measures, inflammatory markers, liver-related laboratory parameters, noninvasive fibrosis-related indices (FIB-4, APRI, NAFLD Fibrosis Score, and BARD score), and an ultrasonographic assessment of hepatic steatosis. Results: Participants assigned to the intermittent fasting regimen showed significant reductions in body weight, body mass index (BMI), and waist circumference compared with controls (all P < 0.001). Marked reductions were also observed in inflammatory markers, particularly the erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). In addition, significant improvements were observed across all evaluated non-invasive fibrosis indices, including FIB-4, APRI, NAFLD Fibrosis Score, and BARD score. Ultrasonographic evaluation demonstrated a greater reduction in hepatic steatosis severity among participants undergoing intermittent fasting than among controls. Conclusions: Intermittent fasting appears to be a feasible and potentially beneficial dietary strategy for patients with NAFLD, with favorable effects on noninvasive, fibrosis-related surrogate markers. Further long-term studies incorporating histological endpoints are needed to clarify its role in preventing or delaying fibrosis progression.
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Investigating the Correlation Between Job-Related Stress and Quality of Work Life Among Physicians Working at Imam Reza and Besat Hospitals of the Islamic Republic of Iran Army in 2025
(Brieflands, 2026-03-31) Mojtaba Dadashkarimi; Morad Esmaeil Zali; Bayram Nejati Zarnaqi; Mohammad hassan Kazemi-Galougahi; Nasrin Jafari-Golestan; Mojtaba Dadashkarimi [0009-0006-3293-2496]; Morad Esmaeil Zali [0000-0001-8733-3286]; Bayram Nejati Zarnaqi [0000-0001-8015-5034]; Mohammad hassan Kazemi-Galougahi [0000-0003-4601-6457]; Nasrin Jafari-Golestan [0000-0002-4532-4776]
Background: Job stress affects physicians’ psychological and physiological well-being and may reduce their quality of work life (QWL). Recent data indicate a 60% prevalence of burnout among military physicians, which is higher than that among civilian physicians. Objectives: This study investigated the association between job stress and QWL among physicians working in Iranian military hospitals. Methods: This cross-sectional study included 139 physicians working at Imam Reza and Besat Military Hospitals in Tehran in 2025. Stratified random sampling by specialty was used. The inclusion criteria were a medical degree and ≥ 6 months of employment; the exclusion criteria were incomplete data or refusal to participate. Ethical approval was obtained from the AJA University Institutional Review Board; informed consent was obtained, and data confidentiality was ensured. Job stress was assessed using the Hellrigel and Slocum Job Stress Questionnaire (Cronbach α = 0.82; validated in Iranian settings), and QWL was evaluated using the Darren Van Laar questionnaire (test-retest reliability, r = 0.72 in the present study). The Shapiro-Wilk test indicated nonnormal distributions, supporting the use of nonparametric tests. Analyses included t tests, analysis of variance, Mann-Whitney U tests, Kruskal-Wallis tests, Spearman correlation, and multivariable linear regression. Effect sizes were calculated as r for Mann-Whitney U tests and Cohen d for t tests. Fisher z transformation was used to compare correlation strengths between male and female physicians. The power calculation was performed using G*Power (power = 0.80, effect size = 0.30, and α = 0.05). Results: Job stress and QWL showed a moderate, significant negative correlation (ρ = -0.553, P < 0.001). The correlation was stronger among female physicians (ρ = -0.719, P < 0.001); however, Fisher z testing showed no significant difference between the correlations for male and female physicians (z = 1.12, P = 0.26). After adjustment for age, gender, experience, and hospital, job stress remained an independent negative predictor of QWL (β = -0.33, P < 0.001), and age was also negatively associated with QWL (β = -0.51, P = 0.040). Gender was not a significant predictor in the adjusted model (P = 0.090). Infectious disease specialists reported the highest stress, whereas ophthalmologists reported the highest QWL (97.75 ± 10.34; 95% CI, 92.12 - 103.38). Domain-specific effect sizes for gender differences in QWL ranged from negligible to small (r = 0.015 - 0.190). The 95% confidence intervals for the median differences were also calculated. Conclusions: Job stress was negatively correlated with QWL among physicians in military hospitals. Organizational interventions and stress-reduction programs may improve the work environment and physicians’ QWL. Although the correlation appeared stronger among female physicians, the difference between genders was not statistically significant.
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Radiolabeling of Amberlite IRA-68 Resin Microspheres with Rhenium-188: Optimization and Biodistribution in Tumor-Bearing Mice Following Intratumoral Administration
(Brieflands, 2026-12-31) Zohreh Zavarzadeh-Moghaddam; Mehdi Salehi Barough; Leila Moghaddam-Banaem; Sodeh Sadjadi; Fariba Johari Daha; Mehdi Salehi Barough [0000-0002-5680-0002]; Leila Moghaddam-Banaem [0000-0002-0046-0731]; Fariba Johari Daha [0000-0002-4395-941X]
Background: Rhenium-188 (188Re) is a therapeutic radionuclide with favorable nuclear properties, including high beta energy and a suitable half-life, making it attractive for radiopharmaceutical applications. Solid carriers, such as ion-exchange resins, may improve radionuclide stability, loading efficiency, and controlled delivery. Objectives: This study aimed to activate Amberlite IRA-68 anion-exchange resin microspheres, optimize their labeling with rhenium and 188Re, and evaluate the biodistribution of the radiolabeled microspheres following intratumoral injection in tumor-bearing mice at 24 and 48 h post-administration. Methods: The effects of contact time, temperature, pH, and initial rhenium concentration on labeling efficiency were systematically investigated. Resin labeling was evaluated by elemental composition analysis using a scanning electron microscope (SEM) equipped with an energy-dispersive X-ray (EDX) analyzer. Radiochemical purity was assessed by instant thin-layer chromatography (ITLC). Activity distribution in mouse organs was assessed using the ISOMED 1010 dose calibrator. Results: The results demonstrated high labeling efficiency; under optimal conditions (rhenium initial concentration 10 ppm, pH 7, 25 °C, 120 min), rhenium uptake reached approximately 98%. Following intratumoral administration, the radiolabeled microspheres showed high tumor retention (5.39%ID/g at 24 h), whereas radioactivity in the blood and normal organs remained relatively low. This retention indicates localized persistence of the injected microspheres rather than active biological targeting. These findings support the potential of Amberlite IRA-68 resin microspheres as an effective carrier for 188Re-based radiopharmaceutical applications. Conclusions: In this study, Amberlite IRA-68 anion-exchange resin microspheres were successfully evaluated as a carrier system for rhenium and rhenium-188. The results demonstrated high labeling efficiency, reaching approximately 98% under optimized conditions (10 ppm, pH 7, 25 °C, 120 min), indicating a strong affinity between the resin and perrhenate ions. The biodistribution study demonstrated that 188Re-labeled Amberlite IRA-68 microspheres showed favorable in vivo characteristics following intratumoral administration. The radiopharmaceutical showed high tumor accumulation at 24 h (%ID/g = 5.39), with persistent retention at 48 h and low blood activity, indicating minimal systemic leakage and limited uptake in critical organs.
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A Narrative Review of the Applications of Artificial Intelligence in Diabetes Patient Education
(Brieflands, 2026-03-31) Azizeh Barry; Hedyeh Hamzeh Zadeh Germi; Ali Mohammad Narimani Ghoortlar
Context: Given the increasing prevalence of diabetes and its substantial health consequences, artificial intelligence (AI) has attracted increasing attention as an innovative approach to patient education and self-care management. However, comprehensive evidence regarding the role of AI in diabetes-related education and care remains limited. This narrative review examined the applications, outcomes, and challenges of AI in educating patients with diabetes. Evidence Acquisition: This narrative review identified relevant articles through searches of PubMed, Scopus, Web of Science, Springer, and Google Scholar. Studies published between 2015 and 2025 were considered, with particular emphasis on publications from the past five years. Search terms included artificial intelligence, self-management, chatbots, mobile applications, patient education, and diabetes. Studies were included if they directly addressed AI technologies used for patient education or self-management in diabetes. Results: AI-based interventions were categorized into four main groups: 1) chatbots and virtual assistants, 2) mobile applications, 3) intelligent educational systems, and 4) large language models. These technologies demonstrated potential to improve diabetes education, support self-management behaviors, and enhance patient engagement. Conclusions: AI-based educational tools show promising potential to support diabetes education, self-management behaviors, patient engagement, glycemic outcomes, and treatment adherence through personalized education, continuous interaction, and feedback. However, findings remain heterogeneous, the overall quality of the evidence has not been systematically evaluated, and conclusions should therefore be interpreted cautiously. Data privacy concerns, the lack of standardized evaluation frameworks, limited accessibility, and the need for professional supervision remain key barriers to widespread implementation.
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Pesticide Use Practices and Cardiovascular-Metabolic Health Among Rice Farmers in Southeastern Nigeria: A Secondary Analysis of Data from Companion Studies
(Brieflands, 2026-06-30) Odochi Chukwu Ogbu; Raphael C. Anakwue
Background: Smallholder rice farmers in Nigeria are frequently exposed to herbicides, raising concerns regarding potential cardiovascular and metabolic health risks. However, evidence on associations between specific herbicides, subclinical inflammation, and cardiac alterations in African farming populations remains limited. Objectives: This study aimed to characterize patterns of herbicide use, occupational safety practices, and lifestyle factors among smallholder rice farmers in Ebonyi State, Nigeria, and to describe the association of specific herbicide exposures with subclinical inflammatory and electrocardiographic indicators of cardiovascular risk. Methods: This secondary analysis integrated inflammatory marker and electrocardiographic data from separate companion manuscripts currently under review ("Electrocardiographic Abnormalities Among Pesticide-Exposed Rice Farmers in Southeast Nigeria," and "Biomarkers Profile of Subclinical Cardio-Metabolic Dysfunction in Pesticide-Exposed Rice Farmers") with newly collected questionnaire data on herbicide use patterns, safety practices, and self-reported health outcomes among 48 rice farmers and 39 nonfarming controls in Ebonyi State, Nigeria. Inflammatory markers (C-reactive protein [CRP], interleukin-6 [IL-6], and tumor necrosis factor α [TNF-α]) and electrocardiographic parameters (PR interval, QRS duration, and T-axis) were descriptively stratified by specific herbicide exposures. Results: Herbicide use was dominated by oxadiazon (28.09% for the Riceforce formulation and 11.24% for Ronstar), pendimethalin (24.72%), and butachlor (22.47% for Cleweed and 13.48% for Butaclear). Self-reported cardiovascular conditions were more prevalent among farmers (35.4%) than among controls (20.5%). Descriptive stratification of inflammatory and cardiac conduction indicators from the companion study showed that farmers exposed to oxadiazon (Riceforce) had the highest mean CRP (12.3 ± 1.2 ng/mL), IL-6 (14.1 ± 0.8 pg/mL), and PR interval (241.2 ± 14.3 ms) compared with controls (5.4 ± 0.9 ng/mL, 8.2 ± 0.5 pg/mL, and 158.3 ± 12.1 ms, respectively; all P < 0.001). Conclusions: Occupational herbicide exposure among rice farmers in southeastern Nigeria may contribute to early cardiovascular risk, compounded by lifestyle factors and insufficient safety practices. These findings underscore the need for targeted interventions, including pesticide safety training, integrated weed management, and community-based health surveillance.